Genome sequencing in persistently unsolved white matter disorders

por Helman, Guy, Lajoie, Bryan R., Crawford, Joanna, Takanohashi, Asako, Walkiewicz, Marzena, Dolzhenko, Egor, Gross, Andrew M., Gainullin, Vladimir G., Bent, Stephen J., Jenkinson, Emma M., Ferdinandusse, Sacha, Waterham, Hans R., Dorboz, Imen, Bertini, Enrico, Miyake, Noriko, Wolf, Nicole I., Abbink, Truus E. M., Kirwin, Susan M., Tan, Christina M., Hobson, Grace M., Guo, Long, Ikegawa, Shiro, Pizzino, Amy, Schmidt, Johanna L., Bernard, Genevieve, Schiffmann, Raphael, van der Knaap, Marjo S., Simons, Cas, Taft, Ryan J., Vanderver, Adeline
Publicado 2020

Immunology of COVID-19: Current State of the Science

por Vabret, Nicolas, Britton, Graham J., Gruber, Conor, Hegde, Samarth, Kim, Joel, Kuksin, Maria, Levantovsky, Rachel, Malle, Louise, Moreira, Alvaro, Park, Matthew D., Pia, Luisanna, Risson, Emma, Saffern, Miriam, Salomé, Bérengère, Esai Selvan, Myvizhi, Spindler, Matthew P., Tan, Jessica, van der Heide, Verena, Gregory, Jill K., Alexandropoulos, Konstantina, Bhardwaj, Nina, Brown, Brian D., Greenbaum, Benjamin, Gümüş, Zeynep H., Homann, Dirk, Horowitz, Amir, Kamphorst, Alice O., Curotto de Lafaille, Maria A., Mehandru, Saurabh, Merad, Miriam, Samstein, Robert M.
Publicado 2020

Loss of BAP1 function leads to EZH2-dependent transformation

por LaFave, Lindsay M., Béguelin, Wendy, Koche, Richard, Teater, Matt, Spitzer, Barbara, Chramiec, Alan, Papalexi, Efthymia, Keller, Matthew D., Hricik, Todd, Konstantinoff, Katerina, Micol, Jean-Baptiste, Durham, Benjamin, Knutson, Sarah K., Campbell, John E., Blum, Gil, Shi, Xinxu, Doud, Emma H., Krivtsov, Andrei V., Chung, Young Rock, Khodos, Inna, de Stanchina, Elisa, Ouerfelli, Ouathek, Adusumilli, Prasad S., Thomas, Paul M., Kelleher, Neil L., Luo, Minkui, Keilhack, Heike, Abdel-Wahab, Omar, Melnick, Ari, Armstrong, Scott A., Levine, Ross L.
Publicado 2015

Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease

por Williams, Alexander T., Chen, Jing, Coley, Kayesha, Batini, Chiara, Izquierdo, Abril, Packer, Richard, Abner, Erik, Kanoni, Stavroula, Shepherd, David J., Free, Robert C., Hollox, Edward J., Brunskill, Nigel J., Ntalla, Ioanna, Reeve, Nicola, Brightling, Christopher E., Venn, Laura, Adams, Emma, Bee, Catherine, Wallace, Susan E., Pareek, Manish, Hansell, Anna L., Esko, Tõnu, Stow, Daniel, Jacobs, Benjamin M., van Heel, David A., Hennah, William, Rao, Balasubramanya S., Dudbridge, Frank, Wain, Louise V., Shrine, Nick, Tobin, Martin D., John, Catherine
Publicado 2023

Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia

por Mansouri, Larry, Sutton, Lesley-Ann, Ljungström, Viktor, Bondza, Sina, Arngården, Linda, Bhoi, Sujata, Larsson, Jimmy, Cortese, Diego, Kalushkova, Antonia, Plevova, Karla, Young, Emma, Gunnarsson, Rebeqa, Falk-Sörqvist, Elin, Lönn, Peter, Muggen, Alice F., Yan, Xiao-Jie, Sander, Birgitta, Enblad, Gunilla, Smedby, Karin E., Juliusson, Gunnar, Belessi, Chrysoula, Rung, Johan, Chiorazzi, Nicholas, Strefford, Jonathan C., Langerak, Anton W., Pospisilova, Sarka, Davi, Frederic, Hellström, Mats, Jernberg-Wiklund, Helena, Ghia, Paolo, Söderberg, Ola, Stamatopoulos, Kostas, Nilsson, Mats, Rosenquist, Richard
Publicado 2015

In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine

por Muthumani, Karuppiah, Griffin, Bryan D, Agarwal, Sangya, Kudchodkar, Sagar B, Reuschel, Emma L, Choi, Hyeree, Kraynyak, Kimberly A, Duperret, Elizabeth K, Keaton, Amelia Anne, Chung, Christopher, Kim, Yinho K, Booth, Stephanie A, Racine, Trina, Yan, Jian, Morrow, Matthew P, Jiang, Jingjing, Lee, Brian, Ramos, Stephanie, Broderick, Kate E, Reed, Charles C, Khan, Amir S, Humeau, Laurent, Ugen, Kenneth E, Park, Young K, Maslow, Joel N, Sardesai, Niranjan Y, Joseph Kim, J, Kobinger, Gary P, Weiner, David B
Publicado 2016

The “sex gap” in COVID-19 trials: a scoping review

por Schiffer, Veronique M.M.M., Janssen, Emma B.N.J., van Bussel, Bas C.T., Jorissen, Laura L.M., Tas, Jeanette, Sels, Jan-Willem E.M., Bergmans, Dennis C.J.J, Dinh, Trang H.T., van Kuijk, Sander M.J., Hana, Anisa, Mehagnoul-Schipper, Jannet, Scheeren, Clarissa I.E., Mesotten, Dieter, Stessel, Bjorn, Marx, Gernot, Hof, Arnoud W.J.van ´t, Spaanderman, Marc E.A., van Mook, Walther N.K.A., van der Horst, Iwan C.C., Ghossein-Doha, Chahinda
Publicado 2020

Evaluate the safety and efficacy of dura sealant patch in reducing cerebrospinal fluid leakage following elective cranial surgery (ENCASE II): study protocol for a randomized, two-...

por Carlson, Andrew P., Slot, Emma M. H., van Doormaal, Tristan P. C., Voormolen, E. H. J., Dankbaar, J. W., Depauw, P., Brouwers, B., Germans, M. R., Baert, E., Vandersteene, J., Freyschlag, C. F., Freyschlag, J., Thomé, C., Zenga, F., Penner, F., Abdulazim, A., Sabel, M., Rapp, M., Beez, T., Zuccarello, M., Sauvageau, E., Abdullah, K., Welch, B., Langer, D., Ellis, J., Dehdashti, A., VanGompel, J., Bendok, B., Chaichana, K., Liu, J., Dogan, A., Lim, M. K., Hayden, M. G.
Publicado 2022

Mutations in the SPG7 gene cause chronic progressive external ophthalmoplegia through disordered mitochondrial DNA maintenance

por Pfeffer, Gerald, Gorman, Gráinne S, Griffin, Helen, Kurzawa-Akanbi, Marzena, Blakely, Emma L., Wilson, Ian, Sitarz, Kamil, Moore, David, Murphy, Julie L., Alston, Charlotte L., Pyle, Angela, Coxhead, Jon, Payne, Brendan, Gorrie, George H., Longman, Cheryl, Hadjivassiliou, Marios, McConville, John, Dick, David, Imam, Ibrahim, Hilton, David, Norwood, Fiona, Baker, Mark R., Jaiser, Stephan R., Yu-Wai-Man, Patrick, Farrell, Michael, McCarthy, Allan, Lynch, Timothy, McFarland, Robert, Schaefer, Andrew M., Turnbull, Douglass M., Horvath, Rita, Taylor, Robert W., Chinnery, Patrick F.
Publicado 2014

Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations

por Gorlova, Olga Y., Li, Yafang, Gorlov, Ivan, Ying, Jun, Chen, Wei V., Assassi, Shervin, Reveille, John D., Arnett, Frank C., Zhou, Xiaodong, Bossini-Castillo, Lara, Lopez-Isac, Elena, Acosta-Herrera, Marialbert, Gregersen, Peter K., Lee, Annette T., Steen, Virginia D., Fessler, Barri J., Khanna, Dinesh, Schiopu, Elena, Silver, Richard M., Molitor, Jerry A., Furst, Daniel E., Kafaja, Suzanne, Simms, Robert W., Lafyatis, Robert A., Carreira, Patricia, Simeon, Carmen Pilar, Castellvi, Ivan, Beltran, Emma, Ortego, Norberto, Amos, Christopher I., Martin, Javier, Mayes, Maureen D.
Publicado 2018

AGILE: a seamless phase I/IIa platform for the rapid evaluation of candidates for COVID-19 treatment: an update to the structured summary of a study protocol for a randomised platf...

por Griffiths, Gareth O., FitzGerald, Richard, Jaki, Thomas, Corkhill, Andrea, Reynolds, Helen, Ewings, Sean, Condie, Susannah, Tilt, Emma, Johnson, Lucy, Radford, Mike, Simpson, Catherine, Saunders, Geoffrey, Yeats, Sara, Mozgunov, Pavel, Tansley-Hancock, Olana, Martin, Karen, Downs, Nichola, Eberhart, Izabela, Martin, Jonathan W. B., Goncalves, Cristiana, Song, Anna, Fletcher, Tom, Byrne, Kelly, Lalloo, David G., Owen, Andrew, Jacobs, Michael, Walker, Lauren, Lyon, Rebecca, Woods, Christie, Gibney, Jennifer, Chiong, Justin, Chandiwana, Nomathemba, Jacob, Shevin, Lamorde, Mohammed, Orrell, Catherine, Pirmohamed, Munir, Khoo, Saye
Publicado 2021

Defining the clinical phenotype of Saul-Wilson syndrome.

por Ferreira, Carlos R., Zein, Wadih M., Huryn, Laryssa A., Merker, Andrea, Berger, Seth I., Wilson, William G., Tiller, George E., Wolfe, Lynne A., Merideth, Melissa, Carvalho, Daniel R., Duker, Angela L., Bratke, Heiko, Haug, Marte Gjøl, Rohena, Luis, Hove, Hanne B., Xia, Zhi-Jie, Ng, Bobby G., Freeze, Hudson H., Gabriel, Melissa, Russi, Alvaro H. Serrano, Brick, Lauren, Kozenko, Mariya, Earl, Dawn L., Tham, Emma, Nishimura, Gen, Phillips, John A., Gahl, William A., Hamid, Rizwan, Jackson, Andrew P., Grigelioniene, Giedre, Bober, Michael B.
Publicado 2020

EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

por Randzavola, Lyra O, Mortimer, Paige M, Garside, Emma, Dufficy, Elizabeth R, Schejtman, Andrea, Roumelioti, Georgia, Yu, Lu, Pardo, Mercedes, Spirohn, Kerstin, Tolley, Charlotte, Brandt, Cordelia, Harcourt, Katherine, Nichols, Esme, Nahorski, Mike, Woods, Geoff, Williamson, James C, Suresh, Shreehari, Sowerby, John M, Matsumoto, Misaki, Santos, Celio XC, Kiar, Cher Shen, Mukhopadhyay, Subhankar, Rae, William M, Dougan, Gordon J, Grainger, John, Lehner, Paul J, Calderwood, Michael A, Choudhary, Jyoti, Clare, Simon, Speak, Anneliese, Santilli, Giorgia, Bateman, Alex, Smith, Kenneth GC, Magnani, Francesca, Thomas, David C
Publicado 2022

Rapid neutrophil mobilization by VCAM-1+ endothelial cell-derived extracellular vesicles

por Akbar, Naveed, Braithwaite, Adam T, Corr, Emma M, Koelwyn, Graeme J, van Solingen, Coen, Cochain, Clément, Saliba, Antoine-Emmanuel, Corbin, Alastair, Pezzolla, Daniela, Møller Jørgensen, Malene, Bæk, Rikke, Edgar, Laurienne, De Villiers, Carla, Gunadasa-Rohling, Mala, Banerjee, Abhirup, Paget, Daan, Lee, Charlotte, Hogg, Eleanor, Costin, Adam, Dhaliwal, Raman, Johnson, Errin, Krausgruber, Thomas, Riepsaame, Joey, Melling, Genevieve E, Shanmuganathan, Mayooran, Bock, Christoph, Carter, David R F, Channon, Keith M, Riley, Paul R, Udalova, Irina A, Moore, Kathryn J, Anthony, Daniel C, Choudhury, Robin P
Publicado 2022

Combined immunodeficiency and Epstein-Barr virus–induced B cell malignancy in humans with inherited CD70 deficiency

por Abolhassani, Hassan, Edwards, Emily S.J., Ikinciogullari, Aydan, Jing, Huie, Borte, Stephan, Buggert, Marcus, Du, Likun, Matsuda-Lennikov, Mami, Romano, Rosa, Caridha, Rozina, Bade, Sangeeta, Zhang, Yu, Frederiksen, Juliet, Fang, Mingyan, Bal, Sevgi Kostel, Haskologlu, Sule, Dogu, Figen, Tacyildiz, Nurdan, Matthews, Helen F., McElwee, Joshua J., Gostick, Emma, Price, David A., Palendira, Umaimainthan, Aghamohammadi, Asghar, Boisson, Bertrand, Rezaei, Nima, Karlsson, Annika C., Lenardo, Michael J., Casanova, Jean-Laurent, Hammarström, Lennart, Tangye, Stuart G., Su, Helen C., Pan-Hammarström, Qiang
Publicado 2017

Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets

por Dugan, Haley L., Stamper, Christopher T., Li, Lei, Changrob, Siriruk, Asby, Nicholas W., Halfmann, Peter J., Zheng, Nai-Ying, Huang, Min, Shaw, Dustin G., Cobb, Mari S., Erickson, Steven A., Guthmiller, Jenna J., Stovicek, Olivia, Wang, Jiaolong, Winkler, Emma S., Madariaga, Maria Lucia, Shanmugarajah, Kumaran, Jansen, Maud O., Amanat, Fatima, Stewart, Isabelle, Utset, Henry A., Huang, Jun, Nelson, Christopher A., Dai, Ya-Nan, Hall, Paige D., Jedrzejczak, Robert P., Joachimiak, Andrzej, Krammer, Florian, Diamond, Michael S., Fremont, Daved H., Kawaoka, Yoshihiro, Wilson, Patrick C.
Publicado 2021

A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2

por Hassan, Ahmed O., Kafai, Natasha M., Dmitriev, Igor P., Fox, Julie M., Smith, Brittany K., Harvey, Ian B., Chen, Rita E., Winkler, Emma S., Wessel, Alex W., Case, James Brett, Kashentseva, Elena, McCune, Broc T., Bailey, Adam L., Zhao, Haiyan, VanBlargan, Laura A., Dai, Ya-Nan, Ma, Meisheng, Adams, Lucas J., Shrihari, Swathi, Danis, Jonathan E., Gralinski, Lisa E., Hou, Yixuan J., Schäfer, Alexandra, Kim, Arthur S., Keeler, Shamus P., Weiskopf, Daniela, Baric, Ralph S., Holtzman, Michael J., Fremont, Daved H., Curiel, David T., Diamond, Michael S.
Publicado 2020

Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility

por Finkel, Terri H., Li, Jin, Wei, Zhi, Wang, Wei, Zhang, Haitao, Behrens, Edward M., Reuschel, Emma L., Limou, Sophie, Wise, Carol, Punaro, Marilynn, Becker, Mara L., Munro, Jane E., Flatø, Berit, Førre, Øystein, Thompson, Susan D., Langefeld, Carl D., Glass, David N., Glessner, Joseph T., Kim, Cecilia E., Frackelton, Edward, Shivers, Debra K., Thomas, Kelly A., Chiavacci, Rosetta M., Hou, Cuiping, Xu, Kexiang, Snyder, James, Qiu, Haijun, Mentch, Frank, Wang, Kai, Winkler, Cheryl A., Lie, Benedicte A., Ellis, Justine A., Hakonarson, Hakon
Publicado 2016

Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2...

por Khoo, Saye H, FitzGerald, Richard, Saunders, Geoffrey, Middleton, Calley, Ahmad, Shazaad, Edwards, Christopher J, Hadjiyiannakis, Dennis, Walker, Lauren, Lyon, Rebecca, Shaw, Victoria, Mozgunov, Pavel, Periselneris, Jimstan, Woods, Christie, Bullock, Katie, Hale, Colin, Reynolds, Helen, Downs, Nichola, Ewings, Sean, Buadi, Amanda, Cameron, David, Edwards, Thomas, Knox, Emma, Donovan-Banfield, I'ah, Greenhalf, William, Chiong, Justin, Lavelle-Langham, Lara, Jacobs, Michael, Northey, Josh, Painter, Wendy, Holman, Wayne, Lalloo, David G, Tetlow, Michelle, Hiscox, Julian A, Jaki, Thomas, Fletcher, Thomas, Griffiths, Gareth
Publicado 2023

Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays

por Pierrat, Olivier A., Liu, Manjuan, Collie, Gavin W., Shetty, Kartika, Rodrigues, Matthew J., Le Bihan, Yann-Vaï, Gunnell, Emma A., McAndrew, P. Craig, Stubbs, Mark, Rowlands, Martin G., Yahya, Norhakim, Shehu, Erald, Talbot, Rachel, Pickard, Lisa, Bellenie, Benjamin R., Cheung, Kwai-Ming J., Drouin, Ludovic, Innocenti, Paolo, Woodward, Hannah, Davis, Owen A., Lloyd, Matthew G., Varela, Ana, Huckvale, Rosemary, Broccatelli, Fabio, Carter, Michael, Galiwango, David, Hayes, Angela, Raynaud, Florence I., Bryant, Christopher, Whittaker, Steven, Rossanese, Olivia W., Hoelder, Swen, Burke, Rosemary, van Montfort, Rob L. M.
Publicado 2022