A Novel, Orally Delivered Antibody Therapy and Its Potential to Prevent Clostridioides difficile Infection in Pre-clinical Models

por Roberts, April K., Harris, Hannah C., Smith, Michael, Giles, Joanna, Polak, Oktawia, Buckley, Anthony M., Clark, Emma, Ewin, Duncan, Moura, Ines B., Spitall, William, Shone, Clifford C., Wilcox, Mark, Chilton, Caroline, Donev, Rossen
Publicado 2020

A truncating mutation in CEP55 is the likely cause of MARCH, a novel syndrome affecting neuronal mitosis

por Frosk, Patrick, Arts, Heleen H, Philippe, Julien, Gunn, Carter S, Brown, Emma L, Chodirker, Bernard, Simard, Louise, Majewski, Jacek, Fahiminiya, Somayyeh, Russell, Chad, Liu, Yangfan P, Hegele, Robert, Katsanis, Nicholas, Goerz, Conrad, Del Bigio, Marc R, Davis, Erica E
Publicado 2017

Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay

por Heywood, Wendy E., Galimberti, Daniela, Bliss, Emily, Sirka, Ernestas, Paterson, Ross W., Magdalinou, Nadia K., Carecchio, Miryam, Reid, Emma, Heslegrave, Amanda, Fenoglio, Chiara, Scarpini, Elio, Schott, Jonathan M., Fox, Nick C., Hardy, John, Bahtia, Kailash, Heales, Simon, Sebire, Neil J., Zetterburg, Henrik, Mills, Kevin
Publicado 2015

A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors

por Menon, Malini, Elliott, Richard, Bowers, Leandra, Balan, Nicolae, Rafiq, Rumana, Costa-Cabral, Sara, Munkonge, Felix, Trinidade, Ines, Porter, Roderick, Campbell, Andrew D., Johnson, Emma R., Esdar, Christina, Buchstaller, Hans-Peter, Leuthner, Birgitta, Rohdich, Felix, Schneider, Richard, Sansom, Owen, Wienke, Dirk, Ashworth, Alan, Lord, Christopher J.
Publicado 2019

Nicotinic Acetylcholine Receptors Are Novel Targets of APETx-like Toxins from the Sea Anemone Heteractis magnifica

por Kalina, Rimma S., Kasheverov, Igor E., Koshelev, Sergey G., Sintsova, Oksana V., Peigneur, Steve, Pinheiro-Junior, Ernesto Lopes, Popov, Roman S., Chausova, Victoria E., Monastyrnaya, Margarita M., Dmitrenok, Pavel S., Isaeva, Marina P., Tytgat, Jan, Kozlov, Sergey A., Kozlovskaya, Emma P., Leychenko, Elena V., Gladkikh, Irina N.
Publicado 2022

Analysis of an independent tumor suppressor locus telomeric to Tp53 suggested Inpp5k and Myo1c as novel tumor suppressor gene candidates in this region

por Hedberg Oldfors, Carola, Dios, Diego Garcia, Linder, Anna, Visuttijai, Kittichate, Samuelson, Emma, Karlsson, Sandra, Nilsson, Staffan, Behboudi, Afrouz
Publicado 2015

Haploinsufficiency of the murine Col3a1 locus causes aortic dissection: a novel model of the vascular type of Ehlers–Danlos syndrome

por Smith, Lee B., Hadoke, Patrick W.F., Dyer, Emma, Denvir, Martin A., Brownstein, David, Miller, Eileen, Nelson, Nancy, Wells, Sara, Cheeseman, Michael, Greenfield, Andy
Publicado 2011

Novel endogenous N-acyl amides activate TRPV1-4 receptors, BV-2 microglia, and are regulated in brain in an acute model of inflammation

por Raboune, Siham, Stuart, Jordyn M., Leishman, Emma, Takacs, Sara M., Rhodes, Brandon, Basnet, Arjun, Jameyfield, Evan, McHugh, Douglas, Widlanski, Theodore, Bradshaw, Heather B.
Publicado 2014

Expanding the FurC (PerR) regulon in Anabaena (Nostoc) sp. PCC 7120: Genome-wide identification of novel direct targets uncovers FurC participation in central carbon metabolism reg...

por Sarasa-Buisan, Cristina, Guío, Jorge, Peleato, M. Luisa, Fillat, María F., Sevilla, Emma
Publicado 2023

Molecular breakpoint cloning and gene expression studies of a novel translocation t(4;15)(q27;q11.2) associated with Prader-Willi syndrome

por Schüle, Birgitt, Albalwi, Mohammed, Northrop, Emma, Francis, David I, Rowell, Margaret, Slater, Howard R, Gardner, RJ McKinlay, Francke, Uta
Publicado 2005

sGCα(1)-deficient mice: a novel murine model of spontaneous primary open angle glaucoma

por Buys, Emmanuel S, Ko, Yu-Chieh, Hayton, Sarah, Jones, Alexander, Tainsh, Laurel, Ren, Ruiyi, Giani, Andrea, Abernathy, Emma, Gong, Haiyan, Rhee, Douglas J, Brouckaert, Peter, Gregory, Meredith, Pasquale, Louis R, Bloch, Kenneth D, Ksander, Bruce
Publicado 2011

A novel cause of DKC1‐related bone marrow failure: Partial deletion of the 3′ untranslated region

por Arthur, Jonathan W., Pickett, Hilda A., Barbaro, Pasquale M., Kilo, Tatjana, Vasireddy, Raja S., Beilharz, Traude H., Powell, David R., Hackett, Emma L., Bennetts, Bruce, Curtin, Julie A., Jones, Kristi, Christodoulou, John, Reddel, Roger R., Teo, Juliana, Bryan, Tracy M.
Publicado 2021

A novel ATP1A2 mutation in a patient with hypokalaemic periodic paralysis and CNS symptoms

por Sampedro Castañeda, Marisol, Zanoteli, Edmar, Scalco, Renata S, Scaramuzzi, Vinicius, Marques Caldas, Vitor, Conti Reed, Umbertina, da Silva, Andre Macedo Serafim, O’Callaghan, Benjamin, Phadke, Rahul, Bugiardini, Enrico, Sud, Richa, McCall, Samuel, Hanna, Michael G, Poulsen, Hanne, Männikkö, Roope, Matthews, Emma
Publicado 2018

Detailed statistical analysis plan for a cluster randomised controlled trial of the Healthy Lifestyles Programme (HeLP), a novel school-based intervention to prevent obesity in sch...

por Creanor, Siobhan, Lloyd, Jenny, Hillsdon, Melvyn, Dean, Sarah, Green, Colin, Taylor, Rod S., Ryan, Emma, Wyatt, Katrina
Publicado 2016

A Novel Role for Lymphotactin (XCL1) Signaling in the Nervous System: XCL1 Acts via its Receptor XCR1 to Increase Trigeminal Neuronal Excitability

por Bird, Emma V., Iannitti, Tommaso, Christmas, Claire R., Obara, Ilona, Andreev, Veselin I., King, Anne E., Boissonade, Fiona M.
Publicado 2018

A randomised phase 1 study to investigate safety, pharmacokinetics and impact on gut microbiota following single and multiple oral doses in healthy male subjects of SMT19969, a nov...

por Vickers, Richard, Robinson, Neil, Best, Emma, Echols, Roger, Tillotson, Glenn, Wilcox, Mark
Publicado 2015

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

por Oikonomidi, Ioanna, Burbridge, Emma, Cavadas, Miguel, Sullivan, Graeme, Collis, Blanka, Naegele, Heike, Clancy, Danielle, Brezinova, Jana, Hu, Tianyi, Bileck, Andrea, Gerner, Christopher, Bolado, Alfonso, von Kriegsheim, Alex, Martin, Seamus J, Steinberg, Florian, Strisovsky, Kvido, Adrain, Colin
Publicado 2018

SLAMF6​ deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint

por Hajaj, Emma, Eisenberg, Galit, Klein, Shiri, Frankenburg, Shoshana, Merims, Sharon, Ben David, Inna, Eisenhaure, Thomas, Henrickson, Sarah E, Villani, Alexandra Chloé, Hacohen, Nir, Abudi, Nathalie, Abramovich, Rinat, Cohen, Jonathan E, Peretz, Tamar, Veillette, Andre, Lotem, Michal
Publicado 2020

The therapeutic potential of the novel angiotensin-converting enzyme 2 in the treatment of coronavirus disease-19

por Oyagbemi, Ademola Adetokunbo, Ajibade, Temitayo Olabisi, Aboua, Yapo Guillaume, Gbadamosi, Idayat Titilayo, Adedapo, Aduragbenro Deborah A., Aro, Abimbola Obemisola, Adejumobi, Olumuyiwa Abiola, Thamahane-Katengua, Emma, Omobowale, Temidayo Olutayo, Falayi, Olufunke Olubunmi, Oyagbemi, Taiwo Olaide, Ogunpolu, Blessing Seun, Hassan, Fasilat Oluwakemi, Ogunmiluyi, Iyanuoluwa Omolola, Ola-Davies, Olufunke Eunice, Saba, Adebowale Benard, Adedapo, Adeolu Alex, Nkadimeng, Sanah Malomile, McGaw, Lyndy Joy, Kayoka-Kabongo, Prudence Ngalula, Yakubu, Momoh Audu, Oguntibeju, Oluwafemi Omoniyi
Publicado 2021

Asymptomatic Infant With Atypical SCID and Novel Hypomorphic RAG Variant Identified by Newborn Screening: A Diagnostic and Treatment Dilemma

por Chitty-Lopez, Maria, Westermann-Clark, Emma, Dawson, Irina, Ujhazi, Boglarka, Csomos, Krisztian, Dobbs, Kerry, Le, Khuong, Yamazaki, Yasuhiro, Sadighi Akha, Amir A., Chellapandian, Deepak, Oshrine, Ben, Notarangelo, Luigi D., Sunkersett, Gauri, Leiding, Jennifer W., Walter, Jolan E.
Publicado 2020