“…In this study, we investigated the effects of varying intensity levels of repeated moderate noise exposures on hearing. The aim was to define an appropriate intensity level that could be repeated several times without giving rise to a permanent hearing loss, and thus establish a model for early adulthood moderate noise exposure in rats. …”
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“…Exposure to secondhand smoke (SHS) not only can cause serious illness, but is also an economic and social burden. …”
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“…BACKGROUND: The Environmental Exposure Unit (EEU) in Kingston, Ontario, Canada is a controlled allergen challenge facility (CACF) that has been previously clinically validated for the use of ragweed and grass pollen in clinical studies. …”
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“…Mere-exposure (ME) research has found that initially neutral objects made familiar are preferred relative to novel objects. …”
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“…The reasons are not well known. We examined pre-exposure gene expression in baboons (n = 17) who developed haematologic acute radiation syndrome (HARS) without pancytopenia or a more aggravated HARS with pancytopenia after irradiation. …”
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“…Workers in the heat-exposure risk group are defined as workers who work in conditions that cause them to spend more than 25% of their work hours at high temperatures. …”
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“…The environment plays a major role in human health, yet tools to study the health impacts of complex environmental exposures are lacking. In 2005, Christopher Wild introduced the concept of the exposome, which encompasses environmental exposures and concomitant biological responses throughout the life course. …”
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“…OBJECTIVE: Quantify fireline carbon monoxide (CO) exposures in WFFs and identify predictors of exposures. …”
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“…The present study aimed to evaluate the optimal exposure intensity indicators of airborne lead exposure by comparing to blood lead measurements for the future development of the carcinogen exposure intensity database. …”
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“…The exposome is defined as the cumulative measure of external exposures on an organism (external exposome), and the associated biological responses (endogenous exposome) throughout the lifespan, from conception and onwards. …”
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“…GENERAL FEATURES: The presented implementation allows the conduct of: (i) data pre-processing: normalization and missing imputation (including limit of detection); (ii) descriptive analysis; (iii) exposome principal component analysis (PCA) and hierarchical clustering; (iv) exposome-wide association studies (ExWAS) and variable selection ExWAS; (v) omic data integration by single association and multi-omic analyses; and (vi) post-exposome data analyses to gain biological insight for the exposures, genes or using the Comparative Toxicogenomics Database (CTD) and pathway analysis. …”
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“…This new data on the gut microbial exposome, freely available in Exposome-Explorer (http://exposome-explorer.iarc.fr/), will help researchers to identify poorly studied microbial metabolites to be considered in future studies on the gut microbiota, and study their functionalities and role in health and diseases.…”
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“…BACKGROUND: Exposure to advertising of unhealthy commodities such as fast-food and gambling is recognised as a risk factor for developing non-communicable diseases. …”
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“…Setting CoU requires the risk assessment of all relevant Contributing Scenarios (CSs) in the exposure scenario. A new CS has to be created whenever an Operational Condition (OC) is changed, resulting in an excessive number of exposure assessments. …”
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“…In these cases, and in the rare cases of high temperature tolerance assessments, all exposures had been during a single stress event. In the present study, we examined the physiological consequences of repeated high temperature exposure with recovery periods between these stress events in Myzus persicae. …”
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