“…We found that intracellular chloride concentration ([Cl(−)](i)) in astrocytes is high and stable during sleep. In awake mice astrocytic [Cl(−)](i) is lower and exhibits large fluctuation in response to both sensory input and motor activity. …”
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“…A similar pattern, partially attributed to burst spiking, is seen in thalamic nuclei and is associated with a pronounced late component in the evoked EEG. We infer that cortico-thalamo-cortical interactions drive the long-lasting evoked EEG signals elicited by deep cortical stimulation during the awake state. …”
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“…Notably, the frequency peak of hemodynamic signals can be different from that of LFP oscillations in awake mice. …”
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“…Here we describe the methods by which we adapted the relevant human psychophysical methods to awake, behaving monkeys and replicated key previous psychophysical results. …”
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“…However, whether rapid changes in basal forebrain neuron spiking in awake animals can dynamically influence sensory perception is unclear. …”
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“…Here we took advantage of genetically encoded voltage indicators (GEVIs) that allow for cell type-specific monitoring of population voltage dynamics in a chronic dual-hemisphere transcranial windowed mouse preparation to directly compare the cortex-wide broadcasting of sensory information in wakening (lightly anesthetized to sedated) and awake mice. Somatosensory-evoked cortex-wide dynamics is altered across brain states, with anatomically sequential hyperpolarising activity observed in the awake cortex. …”
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“…We found that optogenetic activation of the sleep switch suppressed behavioral responsiveness to mechanical stimuli, even in awake flies, indicating a broader role for these neurons in regulating arousal. …”
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“…We developed a method enabling us to image the first layer of non-lemniscal IC (IC shell L1) in awake behaving mice. Compared with the awake state, spectral tuning selectivity of excitatory neurons was decreased during isoflurane anesthesia. …”
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“…Building on a computational single-neuron model that generates stimulus-locked responses with stimulus evoked excitation followed by strong inhibition, we find that stimulus-evoked short-term depression is sufficient to produce synchronized monotonic positive and negative responses to slowly repeated stimuli. …”
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“…Ommaya reservoir placement was performed via an awake procedure rather than under general anesthesia due to airway concerns. …”
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“…Here, we test this model and observe that cocaine increases the activity of both pathways in the striatum of awake mice. These changes are linked to a dopamine-dependent cocaine-induced strengthening of upstream orbitofrontal cortex (OFC) inputs to the dorsomedial striatum (DMS) in vivo. …”
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“…Demonstrating high-throughput monitoring of hemodynamics in the awake brain, we expect Bessel TPLSM to make broad impacts on neurovasculature research.…”
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“…Here, we describe a methodology for direct quantification of CSF production in awake mice. We measure CSF production by placing a catheter in a lateral ventricle, while physically blocking outflow from the 4(th) ventricle. …”
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“…With a sample of 123 PLWD, baseline salivary cortisol was collected at awaking, 30 minutes after awaking, and bedtime. Depressive symptoms were assessed at baseline and the four-week follow-up. …”
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“…Glioblastoma multiforme (GBM) is an aggressive cancer type, with fewer than 3–5% of patients surviving for more than 3 years. We describe a 48-year-old right-handed man who presented with generalized seizure attacks. …”
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“…Although rare, the thumb can trigger because of de Quervain disease. An 18-year-old woman presented with painful triggering during thumb movements. …”
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“…Wide-awake local anesthesia no tourniquet (WALANT) hand surgery at 1 Military Hospital in South Africa resulted in a positive patient experience and beneficial financial outcomes in an economically constrained environment. …”
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“…• Awake, emergency, intervention for an unsecured critical upper airway obstruction is a challenge. • Aerosolization and risk of COVID  of 19 transmission add to the already existing difficulty. • Adequate personal protection and  minimum aerosol generation are  the keys to the success.…”
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“…This editorial evaluates a large observational study that identified strong associations between awake prone positioning and decreased mortality in hospitalised patients with COVID-19 https://bit.ly/3m3NeAx…”
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“…Wearable robots have been growing exponentially during the past years and it is crucial to quantify the performance effectiveness and to convert them into practical benchmarks. …”
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