“…This approach screens the endogenously expressed odorant receptors against an odor in one set of experiments, using awake and freely behaving mice. In combination with validations in a heterologous system, we identify sets of odorant receptors for two odorants, acetophenone and 2,5–dihydro–2,4,5–trimethylthiazoline (TMT), encompassing 69 odorant receptor–odorant pairs. …”
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“…The existence of bistability in vivo in awake animals is disputed. Here, by recording intracellularly from Purkinje neurons in unanesthetized larval zebrafish (Danio rerio), we unequivocally demonstrate bistability in these neurons. …”
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“…We determined the response properties of ~28,000 thalamic boutons and ~4,000 cortical neurons in layers 1–5 of awake mouse V1. With adaptive optics allowing accurate measurement of bouton activity deep in cortex, we found that around half of the boutons in the main thalamorecipient L4 carry orientation-tuned information, and their orientation/direction biases are also dominant in the L4 neuron population, suggesting that these neurons may inherit their selectivity from tuned thalamic inputs. …”
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“…Participants were patients referred to Amir Kabir Hospital in Arak who suffered from Expulsive Anger and Impulsive Behaviors. …”
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“…Changes in serotonin levels in the dorsal raphe nucleus showed opposite trends in the FS and PS rats that were startled awake. No differences were found in other sleep/arousal systems. …”
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“…First, while sensory and movement-evoked synaptic input was tightly correlated across layers, spontaneous action potentials and slow spontaneous subthreshold fluctuations had laminar-specific timing; second, longer duration forepaw movement was associated with a decorrelation of subthreshold activity; third, spontaneous and sensory-evoked forepaw movements were signaled more strongly by L5 than L2/3 neurons. …”
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“…We have previously identified neurons tuned to spectral contrast of wideband sounds in auditory cortex of awake marmoset monkeys. Because additive noise alters the spectral contrast of speech, contrast-tuned neurons, if present in human auditory cortex, may aid in extracting speech from noise. …”
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“…We used models of whisker bending to quantify mechanical signals (forces and moments) at the whisker base while simultaneously monitoring whisker kinematics and recording single Vg units in both anesthetized rats and awake, body restrained rats. We employed a novel manual stimulation technique to deflect whiskers in a way that decouples kinematics from mechanics, and used Generalized Linear Models (GLMs) to show that Vg neurons more directly encode mechanical signals when the whisker is deflected in this decoupled stimulus space. …”
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“…The surgery was completed; the patient remained comfortable and awake without the need for further analgesics. CONCLUSION: Quadratus lumborum block may be a useful anesthetic technique to perform femoral–femoral bypass.…”
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“…To address the coding principles underlying such auditory asymmetries, we recorded a large sample of auditory cortex neurons using two-photon calcium imaging in awake mice, while playing sounds ramping up or down in intensity. …”
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“…This study assessed some traditional fermented beverages and found that some beverages are prone to methanol contamination including cachaca, cholai, agave, arak, plum and grape wines. Possible microbial role in the production of methanol and other volatile congeners in these fermented beverages were discussed. …”
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“…However, spinal surgery has also used minimally invasive techniques that were performed in prone position for more than 30 years to date. Although procedures in both these neurosurgical techniques require the patient to be awake for a certain period of time, the main surgical difference with minimally invasive spinal surgery is that the patients are in the prone position, which may result in increased requirement of airway management because of deep sedation. …”
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“…CASE REPORT: We present the case of a 59-year-old male with rapidly progressive emphysematous epiglottitis managed with awake fiber optic intubation followed by incision, drainage, and antibiotic therapy. …”
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“…Here, using single-unit recordings in auditory cortex of awake mice, we show that this may not generally hold true. …”
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“…The complex bulk compliance (dynamic compressibility) of a commercial sample of poly (vinyl acetate), AYAT, was measured at frequencies from 50 to 1,000 cycles per second, temperatures from 0 to 100 °C, and static hydrostatic stresses from 0 to 981 bars (gage pressure) using an alternating hydrostatic stress generated and detected by piezoelectric transducers mounted in an essentially noncompliant cavity with dimensions small in comparison to a wavelength. …”
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“…Single-neuron in vivo recordings in awake α(3)(+/D801Y) mice revealed irregular firing of Purkinje cells and their synaptic targets, the deep cerebellar nuclei neurons, which was further exacerbated during dystonia and evolved into abnormal high-frequency burst-like firing. …”
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“…Physiological responses to nociceptive stimuli are initiated within tens of milliseconds, but the corresponding sub-second behavioral responses have not been adequately explored in awake, unrestrained animals. A detailed understanding of these responses is crucial for progress in pain neurobiology. …”
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“…Specifically, we suggest that beta-mediated ensemble formation within and between cortical areas may awake, rather than merely preserve, an endogenous cognitive set in the service of current task demands. …”
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“…We pharmacologically induced focal seizures in primary visual cortex (V1) of awake mice, and compared their propagation to the retinotopic organization of V1 and higher visual areas. …”
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“…We show that systemic and raphe nucleus d-serine administration to awake, unrestrained mice increases the respiratory frequency. …”
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