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  1. 14001
    por Fahlman, Andreas, Madigan, Johnny
    Publicado 2016
    “…The average sCL of sea lions was 0.41 ± 0.11 cmH(2)O(−1), which is similar to those measured in anesthetized sea lions and awake cetaceans, and significantly higher as compared to humans (0.08 cmH(2)O(−1)). …”
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    Respiratory Function in Voluntary Participating Patagonia Sea Lions (Otaria flavescens) in Sternal Recumbency
  2. 14002
    “…The model is parameterized and tuned to simulate alpha (8–13 Hz) rhythm that is dominant in both Local Field Potential (LFP) of LGN and electroencephalogram (EEG) of visual cortex in an awake resting state with eyes closed. The results show that: First, the response of the TRN is suppressed in the presence of IN in the circuit; disconnecting the IN from the circuit effects a dramatic change in the model output, displaying high amplitude synchronous oscillations within the alpha band in both TCR and TRN. …”
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    Causal Role of Thalamic Interneurons in Brain State Transitions: A Study Using a Neural Mass Model Implementing Synaptic Kinetics
  3. 14003
    “…Patients requiring suppression of haemodynamic responses would require awake extubation with pharmacological attenuation or extubation under deep anaesthesia using supraglottic devices as bridge. …”
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    All India Difficult Airway Association 2016 guidelines for the management of anticipated difficult extubation
  4. 14004
    “…Here, we demonstrate that the antidepressant-like efficacy of three unique drugs, with reported rapid onset antidepressant properties, is coupled with a rapid transient rise in glutamate cycling in medial prefronal cortex (mPFC) of awake rats as measured by ex vivo (1)H-[(13)C]-nuclear magnetic resonance spectroscopy. …”
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    Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects
  5. 14005
    por Kanamori, Keiko
    Publicado 2017
    “…Following unilateral intrahippocampal injection of kainate, GLU(ECF) was collected by microdialysis from the CA1/CA3 region of awake rats, in combination with EEG recording of chronic-phase recurrent seizures and intravenous infusion of [2,5-(13)C]glucose. …”
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    Faster flux of neurotransmitter glutamate during seizure — Evidence from (13)C-enrichment of extracellular glutamate in kainate rat model
  6. 14006
    “…Selected cities were Sari, Birjand, Ardabil, Mashhad, Bandar Abbas, Dezful, Yazd, and Arak, in Iran in 2013. Totally, 4614 schoolchildren were selected, 4106 of which participated in the study. …”
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    Sensitivity and Specificity of Preschool Vision Screening in Iran
  7. 14007
    “…METHODS: Transgenic Tg2576 mice and WT mice, >18 months were injected intraperitonally with ≈ 25 to 30 MBq (18)F-FDG while awake. After 60 minutes, they were anesthetized with isoflurane (2.5%) and imaged with Inveon MicroPET. …”
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    Brain and Brown Adipose Tissue Metabolism in Transgenic Tg2576 Mice Models of Alzheimer Disease Assessed Using (18)F-FDG PET Imaging
  8. 14008
    “…CONCLUSIONS: Millions of MPCs can be harvested from a sample smaller than 1 g, which can be collected from a fully awake donor in an outpatient setting without the need for general anesthesia or hospitalization. …”
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    Harvesting multipotent progenitor cells from a small sample of tonsillar biopsy for clinical applications
  9. 14009
    “…METHODS: Twenty critically ill adult patients undergoing or having undergone mechanical ventilation for ≥24 h received daily 20-min neurocognitive stimulation sessions when awake and alert during their ICU stay. The difficulty of the exercises included in the sessions progressively increased over successive sessions. …”
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    Feasibility and safety of virtual-reality-based early neurocognitive stimulation in critically ill patients
  10. 14010
    “…Over the last 40 years, job burnout has attracted a great deal of attention among researchers and practitioners and, after decades of research and interventions, it is still regarded as an important issue. …”
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    Burnout Disrupts Anxiety Buffer Functioning Among Nurses: A Three-Way Interaction Model
  11. 14011
    “…As medial prefrontal cortex (mPFC) and hippocampus play important roles in memory and emotion, we used multi-site, multi-electrode recordings of oscillatory neuronal activity in local field potentials (LFPs) in awake, head-fixed mice to determine if the functioning of these regions was abnormal after mTBI, using a closed-skull focal cranial blast model. …”
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    Abnormalities in Dynamic Brain Activity Caused by Mild Traumatic Brain Injury Are Partially Rescued by the Cannabinoid Type-2 Receptor Inverse Agonist SMM-189
  12. 14012
    “…The mean (SD) time to awake was longer in Group PM compared to Group P [21.2 (5.6) minutes vs. 23.0 (7.1) minutes; mean difference, 1.8 min; 95% CI, 0.9–2.9; p < 0.001]. …”
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    A comparison of the use of propofol alone and propofol with midazolam for pediatric magnetic resonance imaging sedation – a retrospective cohort study
  13. 14013
    “…As part of a large clinical sequencing project, WGS500, we sequenced a family in which the two male children had severe developmental delay and a dramatically disturbed sleep-wake cycle, with very long wake and sleep durations, reaching up to 106-h awake and 48-h asleep. The most likely causal variant identified was a novel missense variant in the X-linked GRIA3 gene, which has been implicated in intellectual disability. …”
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    A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability
  14. 14014
    por Abe, Kenta, Yawo, Hiromu
    Publicado 2017
    “…Here, we applied optogenetics to produce somatosensory inputs in the whisker area using one of transgenic rat lines, W-TChR2V4, which expresses channelrhodopsin-2 (ChR2) in the mechanoreceptive nerve endings around whisker follicles. An awake W-TChR2V4 rat was head-fixed and irradiated by blue LED light on the whisker area with a paradigm conditioned with a reward. …”
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    Optogenetic conditioning of paradigm and pattern discrimination in the rat somatosensory system
  15. 14015
    “…Most Saudi migraineurs encounter throbbing, moderately severe headache, that does not awake them from sleep. Females report more severe headaches, whereas more men take medications. …”
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    Prevalence of Migraine Headache in Taif City, Saudi Arabia
  16. 14016
    “…METHODS: In this study, to understand the molecular effects of persistent DO after BOO induction and deobstruction, we performed awake cystometry on female Sprague-Dawley rats divided into 4 groups: a sham group, a BOO group, a deobstructed group with DO after BOO (DDO), and a deobstructed group without DO after BOO (non-DDO). …”
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    Near-Normalized Gene Expression Profiles in Bladder With Detrusor Overactivity in Rats With Bladder Outlet Obstruction After Deobstruction
  17. 14017
    “…Regarding the specific types of sleep problems, self-reported changes in sleep latency (i.e., how long it takes to fall asleep at night), daytime dysfunction (i.e., difficulty staying awake during the day), and sleep quality (i.e., subjective rating of sleep quality) were associated with higher levels of depressive symptoms. …”
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    The effect of sleep pattern changes on postpartum depressive symptoms
  18. 14018
    “…On the other hand, their neighboring provinces with low medical facilities such as Ardebil, West Azerbaijan, Golestan, South and north Khorasans, Qazvin, Markazi, Arak, Sistan & balouchestan, Kigilouye & boyerahmad, Bushehr, Ilam and Hormozgan, had observed fewer cancer cases than their expectation. …”
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    Bayesian correction model for over-estimation and under-estimation of liver cancer incidence in Iranian neighboring provinces
  19. 14019
    “…We attempted to close this gap in knowledge in the present study by recording multi-channel epidural electroencephalogram (EEG) from awake behaving wildtype and Sp4 hypomorphic mice. …”
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    Ketamine independently modulated power and phase-coupling of theta oscillations in Sp4 hypomorphic mice
  20. 14020
    “…METHODS: Microdialysis was performed in awake rats with probes placed into the mPFC. Rats (n = 7/group) received vehicle (saline), cariprazine (0.05, 0.2, or 0.8 mg/kg), or aripiprazole (3 or 20 mg/kg) via gavage. …”
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    Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity
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