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  1. 329461
    “…This case is unique in that radiologic features were more helpful than histopathology in determining the diagnosis and highlights the importance of collectively considering clinical, imaging, and histopathological features in making a final diagnosis. References: 1. Wilms, G., MRI of the pituitary gland, by Jean-François Bonneville, Fabrice Bonneville, Françoise Cattin, Sonia Nagi. …”
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    THU104 An Atypical Case Of A Suprasellar Cyst: A Diagnostic Challenge
  2. 329462
    “…We also performed spatial transcriptomics and scRNA-seq analyses of the GEMMs to comprehensively evaluate the effect of Foxa1 loss on downstream pathways and the surrounding TIME. Finally, we performed bioinformatics analysis of PCa patient datasets to validate the clinical relevance. …”
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    THU479 FOXA1 Loss Remodels The Tumor Immune Microenvironment In Late-stage Prostate Cancer
  3. 329463
    “…These findings do not support the hypothesis that prenatal androgen exposure is a final common path to PCOS in humans. The prevalence of obesity was higher in daughters than in parents and in HA mothers compared mothers without HA suggesting that obesity was associated with features of PCOS. …”
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    THU650 Prevalence Of Hyperandrogenemia, PCOS And Obesity In Mothers Of Daughters With PCOS
  4. 329464
    “…In single-cell RNA sequencing of adipose tissues and coronary arteries, COL6A3 was highly expressed in cell types involved in metabolic dysfunction and fibrosis. Finally, we found that body fat reduction can lower plasma levels of COL6A3-derived endotrophin and other protein mediators and reduce cardiometabolic risk, highlighting clinical translation of these findings. …”
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    THU582 Actionable Circulating Proteins Mediate The Effect Of Obesity On Cardiometabolic Diseases: An Integrative Proteogenomics Analysis
  5. 329465
    “…No difference was found for age and HIV duration comparing patients for low BMD or sarcopenia. Finally, ALMI was directly associated with BMD Z-scores at any site. …”
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    OR29-05 Sarcopenia, Low Bone Mineral Density And Hidden Obesity In Young Adult Men Living With HIV (MLWH): Prevalence And Relationship With Sex Steroids
  6. 329466
    “…En Bloc resection was completed and final pathology was consistent with high grade parathyroid carcinoma infiltrating the adjacent thyroid gland. …”
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    SAT206 A Case Of Parathyroid Carcinoma Presenting As A Parathyroid Adenoma
  7. 329467
    “…Vasculopathy leading to vascular narrowing and malformations are also well described manifestations of NF. Finally, a number of hematological manifestations have been described including thrombocytosis, leukocytosis, myelodysplastic syndrome, acute myeloid leukemia, and lymphoma. …”
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    THU614 Neurofibromatosis Type 1 Presenting With Pheochromocytoma And Severe Vascular And Hematological Manifestations Due To A Novel NF1 Mutation
  8. 329468
    “…The medical diagnosis was finally confirmed by mutation detection in the AAAS gene.We genetically investigated 19 families including 29 patients with clinically diagnosed triple A syndrome. …”
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    THU232 Genetic Study In A Series Of 29 Triple A Syndrome Patients From 19 Sudanese Families - Identification Of Two Novel AAAS Mutations
  9. 329469
    “…In agreement with our previous results in male Arglu1(LKO) mice [1], female Arglu1(LKO) mice were resistant to diet-induced obesity with final body weights compared to HFD-fed Arglu1(fl/fl) mice of 30.6 ± 0.9 g vs 35 ± 1 g (P<0.05). …”
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    SAT002 Liver-specific Loss Of The Nuclear Receptor Co-regulator ARGLU1 Protects Against Diet-induced Obesity In Female Mice Independent Of Food Intake And Energy Expenditure
  10. 329470
    “…Material and Methods We analyzed 116 consecutive patients with newly diagnosed acromegaly between 2012 and 2022. Finally, 89 patients with an MRI-confirmed pituitary tumor, available results of at least 3 GH values in the OGTT before implementation of any treatment were included. …”
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    THU064 Clinical, Radiological Characteristics And Response To Somatostatin Analogues Of Acromegaly Patients With Different Patterns Of Growth Hormone Response After Oral Glucose Load
  11. 329471
    “…We also performed in vitro metabolomics analysis of the mouse liver using mass spectrometry. Finally, we measured glucose production from pyruvate in vivo in the liver and kidney using mass isotopomer distribution analysis. …”
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    THU123 Knockout Of Renal Glut2 Gene Activates The Hypothalamic-pituitary-adrenal Axis To Increase Glucose Production In Mice
  12. 329472
    por Wyatt, Rachael, Gorvin, Caroline M
    Publicado 2023
    “…Gi/o and G12/13 responses from plasma membranes were not affected by the CaSR-dileucine mutant. Finally, we assessed whether the CaSR positive allosteric modulator, cinacalcet, affects sustained signalling. …”
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    OR03-05 Cinacalcet Acts As A Spatially Biased Allosteric Modulator To Enhance CaSR Signaling From Endosomal Membranes
  13. 329473
    “…Serum copeptin levels were measured at sodium-level of >149 mmol/L after hypertonic saline and 60 minutes after arginine infusion, respectively. The final diagnosis was made after treatment response assessment at three-month follow-up blinded to copeptin levels. …”
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    OR20-06 Diagnosing Central Diabetes Insipidus Using Copeptin Upon Hypertonic Saline Versus Arginine Stimulation
  14. 329474
    “…Furthermore, the magnitude of serum levels in both TSAb bioassays correlated with TSH-R-Ab binding (both p<0.001). Finally, seventeen AITD samples showed dual TSH-R-Ab positivity in the TBAb and TSAb bioassays. …”
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    FRI540 A Novel, Rapid, Sensitive Bioassay For Thyrotropin Receptor Stimulatory Antibodies Improves Diagnosis & Management Of Autoimmune Thyroid Disease
  15. 329475
    “…We also aimed to assess the predictive value of TSI immunoassay, as well as the clinical signs and thyroid function tests in predicting Graves’ disease relapse following ATD discontinuation. Finally, follow-up would be continued to check for relapse or long term euthyroid status. …”
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    THU670 Serum TSI Concentration In Patients With Graves’ Disease Undergoing Maintenance-dose Of Antithyroid Drug (ATD) And Its Relationship With Disease Relapse After ATD Withdrawal
  16. 329476
    “…GSH/GSSG ratio, a marker of oxidative stress, was lower in KD cells suggesting increased ROS in these cells. Finally, and definitively, knockdown of at least 60% PPOX protein in H295R cells reduced cortisol output by 2.2-fold (p<0.01) at baseline and 1.9-fold (p<0.0001) in forskolin stimulated cells. …”
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    SAT292 Adrenal Insufficiency Associated With Biallelic Mutations In Porphyria Genes
  17. 329477
    “…Methods: Upon Institutional Review Board approval, we reviewed the charts of all patients with a final diagnosis of DTC between 2012 and 2022. We analyzed demographics, histopathological diagnoses, and molecular oncogenic markers of pathology specimens when available. …”
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    THU223 Molecular Makeup Of Differentiated Thyroid Carcinoma In A Free-standing Children’s Hospital With A Predominantly Hispanic Population
  18. 329478
    “…Only 22% of patients underwent hormonal evaluation. Final diagnoses included 16% malignancy, 9% benign adenoma with overt hormone excess, 40% benign adenoma with incomplete hormonal evaluation and 24% radiographically indeterminate masses. …”
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    THU604 Characterization Of Adrenal Masses In Young Adults At A Tertiary Academic Medical Center
  19. 329479
    “…There was a significant improvement (p-value <0.0001) in fellows’ performance in the post-test when compared with the pre-test following our intervention.Final feedback survey was filled out by 33 of them. …”
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    THU001 Novel Interactive Text-messaging Curriculum For Endocrinology Board Review
  20. 329480
    “…Whole-exome sequencing showed the AIP pathogenic variant c.910C.T, p.R304*, indicative of familial isolated pituitary adenoma, confirmed by the history of two paternal first cousins with gigantism. Finally, a 54-year-old man (case 4), with a personal and family history of neurofibromatosis type 1, was incidentally diagnosed with a 16 mm, apparently non-functional PitNET, for which he is awaiting surgery. …”
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    SAT603 A Heterogeneous Genetic Background Underlies Familial And Young-onset Pituitary Tumors
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