“…A constitutively active FoxM1 mutant lacking critical anaphase-promoting complex/cyclosome ([APC/C]-Cdh1) binding sites was used to evaluate ST3Gal1-mediated regulation of FoxM1 protein. Finally, the prognostic role of ST3Gal1 was determined using an orthotopic xenograft model (3 mice groups comprising nontargeting and 2 clones of ST3GAL1 knockdown in NNI-11 [8 per group] and NNI-21 [6 per group]), and the correlation with patient clinical information. …”
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“…Parents were also asked about their education, employment status and their own QoL based on the 26-item WHOQOL-Bref. Based on the final sampling pool of 1158 persons, a 34.8% response rate of 403 individuals was obtained, including 175 child-parent pairs, 27 child singleton responders and 26 parent singletons. …”
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“…Additionally, costs were retrieved from French health insurance databases and publications. Finally, expert opinion was used for validation purposes or in case of gaps in data. …”
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“…Second, we used data from a mailed survey conducted in 2013-2014 with a stratified random sample of this population (final sample: 849 non-Hispanic white, 567 black, 653 Latino, 219 Filipino, and 314 Chinese). …”
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“…RESULTS: A total of 623 patients received a 4-week run-in treatment with OM/HCTZ, 341 patients were randomized, and finally, 167 patients in the OM/AML/HCTZ group and 171 patients in the OM/HCTZ group were analyzed for the full analysis set. …”
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“…Bivariate analyses showed that head of household (HoH)-related characteristics including reported knowledge of three or more malaria symptoms, having health insurance, being able to pay for medical services, use of LLINs the night before the survey, having a positive attitude, perceiving social support, as well as a high-perceived behavioural control with regard to healthcare seeking, were all significantly associated with prompt and adequate care. In the final logistic regression model, a high-perceived behavioural control (odds ratio (OR) 5.068, p = 0.042), having a health insurance (OR 2.410, p = 0.044) and having knowledge of malaria symptoms (OR 1.654, p = 0.049) significantly predicted prompt and adequate care. …”
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“…During the study period, prehospital notification was performed by emergency medical technicians if the patient met the following criteria: (1) positive Cincinnati Prehospital Stroke Scale (CPSS), (2) symptom onset within 3 h, and (3) a sugar pinprick test result ≥ 60 mg/dL. The demographics, final diagnoses, and data associated with stroke for all patients in the prenotification group and for patients diagnosed with acute stroke within 3 h of symptoms onset were prospectively recorded in the stroke registry. …”
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“…Culture supernatants were collected and applied on ICT cards after 6, 12 and 24 h of in vitro maintenance. Finally, total worm extracts (TWE) were prepared using L. loa microfilariae (Mf) and O. ochengi microfilariae, infective larvae and adult male worms. …”
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“…The steady-state concentration was not reached during the 48-hour infusion and the behavior of plasma concentrations of ropivacaine and levobupivacaine during continuous infusions lasting more than 48 hours remains to be investigated, because they could reach toxic levels. Finally, no differences in the clinical efficacy or in the incidence of adverse effects between groups were found for either local anesthetic.…”
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“…Twenty-nine participants were enrolled and the final analytic sample consisted of 25 participants. …”
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“…Due to the combination of their host-feeding patterns and wide distribution in Germany, Cx. pipiens pipiens form pipiens and Cx. torrentium are potentially most important vectors for pathogens transmitted from birds to humans and the species Ae. vexans for pathogens transmitted from non-human mammals to humans. Finally, the presented study indicated a much broader host range compared to the classifications found in the literature for some of the species, which highlights the need for studies on the host-feeding patterns of mosquitoes to further assess their vector capacity and the disease ecology in Europe. …”
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“…However, patients with atraumatic onset of instability had ASES scores that significantly improved from preoperative levels, while their QuickDASH, SANE and SF-12 Physical Component scores did not. At final follow-up, patients with traumatic onset of instability were significantly more satisfied with outcomes (10 vs 9: p=.028) than those with an atraumatic onset. …”
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“…Patient satisfaction (range, 1-10,10=best) and reasons for activity modification was collected at final follow-up. RESULTS: The mean age was 73 years (range,70-82 years) in 49 shoulders (33 men,11 women,5 bilateral) with a mean acromion-humeral distance of 9.2 mm (range,3.0 -15.9 mm). …”
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“…All subjective outcome scores significantly improved (p<.05) and a 9 out of 10 median satisfaction score was achieved at final follow-up. Patients with moderate pre-operative pain (VAS ≥3) negatively correlated with post-operative SF-12 physical component scores (rho=0.445, p=0.043). …”
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“…Outcome measures included recurrence of dislocation, ASES (American Shoulder and Elbow Scores), Rowe, VAS (Visual Analog Scale), Return to sports and satisfaction scores. Final shoulder ROM (range of motion) and any complications were also reported. …”
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“…Two patients who took narcotics pre-operatively continued to require narcotics at final follow-up. Six shoulders had undergone therapeutic shoulder injections post-operatively. …”
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“…Excluding the failed patients, statistically and clinically significant improvements were found in all outcomes assessments at final follow-up, including Lysholm, IKDC, KOOS, and SF-12 (P<0.001 for all). …”
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“…We then separated participants into three groups (high, middle and low) based on their scores of IAS and UCLA-LS, respectively. Finally, we acquired digital records of smartphone usage from MobileSens and examined the differences in 105 types of smartphone usage behaviors between high-score and low-score group of IAS/UCLA-LS. …”
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“…Outcomes data were available for 130 of 148 shoulders (87.8%) after exclusion of seven shoulders (4.5%) that underwent revision rotator cuff repair before final follow up (n=33/39 in the knotted group [84.6%]; n=97/109 [88.9%] in the knotless group).The mean follow-up was 2.9 years (range, 2.0-5.4 years). …”
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“…The majority of surgical interventions were isolated arthroscopic stabilization procedures, and demonstrated no statistically significant difference in RTP rates when concomitant arthroscopic procedures or open stabilization procedures were performed. Finally, athletes who return to play often did so in a higher percentage of games following surgery than they did prior to injury, and many players were utilized at the same or a higher level by their teams following surgery. …”
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