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330081por Akerele, Mercy I., Zein, Sara A., Pandya, Sneha, Nikolopoulou, Anastasia, Gauthier, Susan A., Raj, Ashish, Henchcliffe, Claire, Mozley, P. David, Karakatsanis, Nicolas A., Gupta, Ajay, Babich, John, Nehmeh, Sadek A.“…This study aims to assess the reproducibility of [(11)C]DPA-713 PET kinetic analysis using population-based input function (PBIF). The final goal is to possibly eliminate the need for AIF. …”
Publicado 2021
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330082por Hernandez-Ramos, Rosa, Aguilera, Adrian, Garcia, Faviola, Miramontes-Gomez, Jose, Pathak, Laura Elizabeth, Figueroa, Caroline Astrid, Lyles, Courtney Rees“…Next, we documented all changes made to our onboarding processes to account for remote recruitment, especially those needed to support patients who were not very familiar with downloading apps onto their mobile phones on their own. Finally, we used the new study procedures to recruit patients (n=11) during the COVID-19 social distancing period. …”
Publicado 2021
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330083por Plain, Bethany, Richter, Michael, Zekveld, Adriana A., Lunner, Thomas, Bhuiyan, Tanveer, Kramer, Sophia E.“…No effect of reward on PEP was demonstrated. Finally, participants with a higher need for recovery score invested more effort, as shown by average PEP reactivity, than those with a lower need for recovery score.…”
Publicado 2020
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330084“…Second, the low carbohydrate dietary intervention outcomes could be used to inform clinicians about an alternative approach to assist T1DM adults in improving their quality of life and glycemic control. Finally, this study could warrant the development of an evidence-based low carbohydrate dietary guideline for adults living with T1DM with the potential to have a profound impact on this population. …”
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330085por Tezuka, Yuta, Atsumi, Nanako, Blinder, Amy, Rege, Juilee, Giordano, Thomas J, Rainey, William E, Turcu, Adina“…In contrast, the estimated ZF area showed a strong positive correlation with age both in men (r=0.59, p=0.0006) and women (r=0.49, p=0.007), while CYP11B1-positive area remained stable across ages (p=0.86). Finally, we measured morning levels of 6 steroids in 149 men and 149 women, with ages between 21–95 years, matched for age and body mass index. …”
Publicado 2021
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330086“…Postoperative calcium was 9.6 mg/dl and PTH 51 pg/ml. Final pathology showed 3.7 x 2.5 x 2cm, hypercellular parathyroid with prominent fibrous band and parafibromin retention compatible with APA. …”
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330087“…Given persistent hypocalcemia, other bloodwork including a bone specific alkaline phosphatase and celiac screen were checked which were unremarkable. Finally, nine months after his denosumab dose, calcitriol was discontinued safely. …”
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330088por Porntharukchareon, Thachanun, Chutpiboonwat, Phronpan, Tangjittrong, Sirinrat, Houngngam, Natnicha, Snabboon, Thiti“…Genetic analysis revealed germline mutation in exon 10 of the RET proto-oncogene (NM_020975.4: c.1858T>G, p.C620G). Finally, MEN 2A with recurrent MTC was diagnoses during pregnancy. …”
Publicado 2021
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330089“…By day 3, laboratory results finally improved. Symptoms completely resolved, and the patient was started on a carbohydrate restricted diet with insulin pump therapy, and discharged home after intensive education by the diabetes team. …”
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330090por Deamicis, Agustina Roldán, Oakley, Robert H, Helguera, Sergio Andonegui, Lenze, Mariela B, Madera, Santiago, Russo, Rosalia I Cordo, Chervo, María F, Schillaci, Roxana, Fresno, Cristóbal, Cidlowski, John A, Elizalde, Patricia V, Proietti, Cecilia J“…By WB we demonstrated that transfection with an ErbB-2 mutant which is unable to translocate to the nucleus and functions as a dominant negative inhibitor of ErbB-2 nuclear migration (hErbB-2ΔNLS), inhibited FKBP51 up-regulation by DHT. Finally, by microarray and bioinformatics analysis we identified 315 differentially expressed genes (DEGs) in the presence of DHT and NErbB-2 eviction. …”
Publicado 2021
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330091por Salas-Lucia, Federico, Bocco, Barbara M L C, Rada, Kristof, Fekete, Csaba, Gereben, Balazs, Bianco, Antonio C“…In the second set of experiments (repeated 3 times), 4.9 ± 2.2pM (125)I-T3 (final concentration) was added to the cellular or axonal compartments. …”
Publicado 2021
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330092por Mourtzi, Niki, Sertedaki, Amalia, Markou, Athina, Piaditis, George P, Katsanis, Nicholas, Traeger-Synodinos, Joanne, Tsigos, Constantine, Charmandari, Evangelia“…Germline variants in calcium channel genes were also detected in three patients: p.V249I in CACNA1H, p.R462Q in CACNA1D and p.L1801M in CACNA1I, while one patient carried an ultra-rare variant (p.R26L) in ATP13A3. Finally, in two patients we identified rare, likely pathogenic variants in two new susceptibility genes for PA: KCNK16 (p.P255H) and CACNA2D3 (p.V55I). …”
Publicado 2021
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330093por Gusov, Timur, Liu, John Chen, Naha, Sowjanya, Marium, F N U, Parimi, Joseph Theressa Nehu, Gundluru, Rajani, Syed, Hasan“…Intraoperative frozen section analysis was read as a cystic parathyroid adenoma. The final pathology report revealed cystic parathyroid tissue favoring parathyroid adenoma with focal atypia. …”
Publicado 2021
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330094por Naher, Kamrun, Thrupthi, Komandur, Samsuddoha, Kazi, Galiveeti, Sneha, Leung, Vivien“…Later was started on Ca carbonate 1250 TID with meals. Finally, after electrolyte correction, the patient clinically improved and was discharged with the plan to follow Calcium at the outpatient clinic. …”
Publicado 2021
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330095por Lugo Lopez, Zahira Marie, Penna, Laurianne El Musa, Ortiz, Arnaldo Nieves, Rivera, Ivan Augusto, Diez, Andrea del Toro, Bossolo, Alex N Gonzalez, Garcia, Michelle Marie Mangual“…Patient was treated with IV isotonic saline and methimazole 10mg oral daily with resolution of symptoms. Finally, diagnosed with Graves’ disease as the cause of hypercalcemia after ruling out other etiologies. …”
Publicado 2021
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330096por del Río-Moreno, Mercedes, Vazquez-Borrego, Mari C, Mahmood, Mariyah, Sarmento-Cabral, Andre, Guzman, Grace, Subbaiah, Papasani V, Cordoba-Chacon, Jose, Kineman, Rhonda Denise“…These results suggest GHR/STAT5b may protect against liver injury not by controlling absolute fat accumulation, but by modifying the fatty acid composition of hepatic lipids. Finally, in order to determine if STAT5b(CA) could also reverse established diet-induced NASH, wild-type mice were fed the HFCF diet for 6 months and then treated with AAV-STAT5b(CA) or AAV-Null vectors, and followed for an additional 3 months. …”
Publicado 2021
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330097“…Adrenal cytochrome P450 11β-hydroxylase (CYP11B1) is a mitochondrial enzyme that catalyzes the final step of glucocorticoid synthesis, converting 11-deoxycortisol (S) and deoxycorticosterone (DOC) to cortisol (F) and corticosterone (CORT), respectively. …”
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330098por McCosh, Richard B, Kreisman, Michael J, Tian, Katherine, Thomas, Steven A, Breen, Kellie M“…Second, NE administered into the paraventricular nucleus, which is innervated by A2 neurons, suppressed pulsatile LH secretion. Finally, ablation of brainstem NE neurons restored estrous cyclicity following chronic glucoprivation (chronic metabolic stress model). …”
Publicado 2021
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330099por Nieman, Lynnette K, Boscaro, Marco, Scaroni, Carla Maria, Deutschbein, Timo, Mezosi, Emese, Driessens, Natacha, Georgescu, Carmen Emanuela, Hubalewska-D, Alicja, Berker, Dilek, Jarzab, Barbara Maria, Maiter, Dominique M, Reincke, Martin, Loli, Paola, Zampetti, Benedetta, Atmaca, Ayşegül, Badiu, Corin P, Beckers, Albert M, Bolanowski, Marek, Cavagnini, Francesco, Unger, Nicole, Giordano, Roberta, Hanzu, Felicia Alexandra, Terzolo, Massimo, Bostnavaron, Martine, Toth, Miklos“…Secondary endpoint was met by 80% of patients who had a mUFC decrease of 50%. Final median metyrapone dose was 1500 (250; 5500) mg/day. …”
Publicado 2021
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330100por Oktavia, Nani, Pratiwi, Chici, Mokoagow, Muhammad Ikhsan, Epriliawati, Marina, Nasaruddin, Jerry, Kshanti, Ida Ayu“…We also found a consistent positive result of urine β-HCG, though it had passed four weeks after the occurrence of vaginal bleeding. Finally, the serum β-HCG examination was carried out and showed an increased result, 290,398 (n <5 mIU/ml). …”
Publicado 2021
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