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330201por Patoulias, Dimitrios Ioannis, Boulmpou, Aristi, Teperikidis, Eleftherios, Katsimardou, Alexandra, Siskos, Fotios, Doumas, Michael, Papadopoulos, Christodoulos E, Vassilikos, Vassilios“…DPP-4 inhibitors resulted in a non-significant decrease in the risk for fatal and non-fatal stroke (RR = 0.96, 95%CI: 0.85-1.08, I(2 )= 0%) and coronary revascularization (RR = 0.99, 95%CI: 0.90-1.09, I(2 )= 0%), Finally, DPP-4 inhibitors demonstrated a neutral effect on the risk for hospitalization due to unstable angina (RR = 1.00, 95%CI: 0.85-1.18, I(2 )= 0%). …”
Publicado 2021
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330202por Sivasundaram, Lakshmanan, Strony, John, Mengers, Sunita, Trivedi, Nikunj, Tanenbaum, Joseph, Salata, Michael, Voos, James, Victoroff, Brian, Karns, Michael, Gillespie, Robert“…RESULTS: In our study, 39 patients were included for final analysis; the mean age of the cohort was 55.7±10.6 years and 66.7% of patients were male. …”
Publicado 2021
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330203por MBA, Eric Makhni, Yedulla, Nikhil, Bernstein, David, Elhage, Kareem, Moutzouros, Vasilios“…RESULTS: A total of 1,143 patient responses were included in the final analysis. The five most frequently asked questions in the PROMIS-UE CAT item bank, which were as follows: “Are you able to carry a heavy object (over 10 pounds /5 kg)?” …”
Publicado 2021
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330204“…A third patient sustained a new injury to the knee 4 years following medial meniscus posterior root repair and underwent partial medial meniscectomy. At final follow-up, PROs were obtained for 17 patients (81%). …”
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330205por Reuter, Laurence, Kästner, Denise, Schmidt, Justine, Weigel, Angelika, Voderholzer, Ulrich, Seidel, Marion, Schwennen, Bianca, Fehrs, Helge, Löwe, Bernd, Gumz, Antje“…After item analysis, dimensionality of the final version of the FABIANA-checklist was tested by Principal Component Analysis (PCA). …”
Publicado 2021
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330206por Gao, Ang, Li, Jun-Yu, Shao, Rui, Wu, Tong-Xuan, Wang, Yong-Qiang, Liu, Xiao-Guang, Yu, Miao“…The mean Cobb angle decreased from 28.9 ± 5.5° to 26.3 ± 5.2° at the final follow-up, despite no statistical significance was observed (t = 1.853, P = 0.102). …”
Publicado 2021
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330207por Tang, Yi-Ping, Zhang, Quan-Bo, Dai, Fei, Liao, Xia, Dong, Zeng-Rong, Yi, Ting, Qing, Yu-Feng“…In 60 cases of AS and 30 cases of HC, 4 circRNAs were subjected to real-time fluorescence quantitative polymerase chain reaction (RT-qPCR), and their correlation with various clinical indicators was analyzed. Finally, the receiver operating characteristic (ROC) curve was used to analyze their potential as AS diagnostic markers. …”
Publicado 2021
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330208por Wang, Wei, Baker, Michelle, Hu, Yue, Xu, Jin, Yang, Dajin, Maciel-Guerra, Alexandre, Xue, Ning, Li, Hui, Yan, Shaofei, Li, Menghan, Bai, Yao, Dong, Yinping, Peng, Zixin, Ma, Jinjing, Li, Fengqin, Dottorini, Tania“…On the contrary, the clonal transmission of ST398 was more intermixed in regard to geographic origin. Finally, we identified genetic determinants of resistance to 10 antimicrobials, discriminating drug-resistant bacteria from susceptible strains in the cohort. …”
Publicado 2021
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330209por Malard, Florent, Gaugier, Béatrice, Gozlan, Joel, Bouquet, Lucie, Fofana, Djeneba, Van De Wyngaert, Zoe, Ikhlef, Souhila, Marjanovitch, Zora, Morand-Joubert, Laurence, Mohty, Mohamad“…In contrast, male gender, and ongoing chemotherapy were associated with a significantly decreased probability of achieving the defined protective anti-S IgG level after two BNT162b2 inocula [odds ratio (OR) 0.126, 95% confidence interval (95% CI) 0.022-0.709, p=0.02; OR 0.146, 95%CI 0.025-0.866, p=0.03, respectively]. Finally, using the IFN-g ELISPOT assay in 12 patients, we found a significant increase in T cell response in 12 MM patients against the S protein, with 7 patients (58%) having an anti-S IgG positive ELISPOT after the second BNT162b2 inoculum. …”
Publicado 2021
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330210por Branagan, Andrew, Lei, Matthew, Yee, Andrew J., O’Donnell, Elizabeth, Castillo, Jorge J., Raje, Noopur, Treon, Steven P., Flynn, Catherine, Burke, Jill, Harrington, Cynthia, Agyemang, Emerentia, Mo, Clifton, Nadeem, Omar, Richardson, Paul G., Maebius, Allison, Onyewadume, Chukwuamaka, Panaroni, Cristina, Meid, Kirsten, Bernstein, Zachary, Lyons, Rebecca, Waterman, Matthew, Gallagher, Raquel, Juleg, Boris, Alter, Galit, Sarosiek, Shayna“…Primary endpoint is S antibody detection 28 days after final vaccination. Secondary endpoints include functional serologic assessments and T-cell responses at 28 days, 6 months, 9 months, and 12 months. …”
Publicado 2021
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330211por Scappaticcio, Lorenzo, Maiorino, Maria Ida, Iorio, Sergio, Docimo, Giovanni, Longo, Miriam, Grandone, Anna, Luongo, Caterina, Cozzolino, Immacolata, Piccardo, Arnoldo, Trimboli, Pierpaolo, Miraglia Del Giudice, Emanuele, Esposito, Katherine, Bellastella, Giuseppe“…We included subjects with age <19 years having thyroid nodules with benign cytology/histology or final histological diagnosis. We excluded subjects with (a) a previous malignancy, (b) a history of radiation exposure, (c) cancer genetic susceptibility syndromes, (d) lymph nodes suspicious for metastases of thyroid cancer at nUS, (e) a family history of thyroid cancer, or (f) cytologically indeterminate nodules without histology and nodules with inadequate cytology. …”
Publicado 2021
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330212por Tkocz, Piotr, Matusz, Tomasz, Kosowski, Łukasz, Walewicz, Karolina, Argier, Łukasz, Kuszewski, Michał, Hagner-Derengowska, Magdalena, Ptaszkowski, Kuba, Dymarek, Robert, Taradaj, Jakub“…The main eligibility criteria were: cancer, pregnancy, electronic and metal implants, acute infections, impaired blood coagulation, cardiac arrhythmias, taking analgesic or anti-inflammatory medications, non-experience of heel pain, or presence of other painful foot conditions. Finally, 60 patients were randomly assigned into two groups: study group (n = 30, mean age 59.9 ± 10.1), treated with HILT (7 W, 149.9 J/cm(2), 1064 nm, 4496 J, 12 min), and placebo-controlled group (n = 30, mean age 60.4 ± 11.9), treated with sham HILT therapy. …”
Publicado 2021
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330213por Widmann, Catherine N, Wieberneit, Michelle, Bieler, Luzie, Bernsen, Sarah, Gräfenkämper, Robin, Brosseron, Frederic, Schmeel, Carsten, Tacik, Pawel, Skowasch, Dirk, Radbruch, Alexander, Heneka, Michael T“…These results are quite robust but are neither final nor placed in the needed context intended at study completion. …”
Publicado 2021
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330214por Patel, Sharad, Singh, Gurkeerat, Zarbiv, Samson, Ghiassi, Kia, Rachoin, Jean-Sebastien“…The hyperparameters selected to train the final models were as follows: colsample_bytree of 0.8, gamma of 1, max_depth of 3, subsample of 1, min_child_weight of 10, and scale_pos_weight of 3. …”
Publicado 2021
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330215“…Using a novel calculation, aPM(2.5) ratio (PMR) change and DALY rate ratio (DARR) change were used to assess each country’s ability to decrease its aPM(2.5) pollution and DALYs to at least the extent of the European median decrease within the analysed period. Finally, we created a multiple regression model for reliably predicting YLL using aPM(2.5) and household air pollution. …”
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330216por Songtaweesin, Wipaporn Natalie, LeGrand, Sara, Bandara, Shashika, Piccone, Caitlin, Wongharn, Prissana, Moonwong, Juthamanee, Jupimai, Thidarat, Saisaengjan, Chutima, Theerawit, Tuangtip, Muessig, Kathryn, Hightow-Weidman, Lisa, Puthanakit, Thanyawee, Phanuphak, Nittaya, Tangmunkongvorakul, Arunrat“…However, partnerships with local app designers and developers can improve the adaptation process and final product. TRIAL REGISTRATION: ClinicalTrials.gov NCT04413708; http://clinicaltrials.gov/ct2/show/NCT04413708…”
Publicado 2021
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330217por Sprooten, Jenny, Vankerckhoven, Ann, Vanmeerbeek, Isaure, Borras, Daniel M, Berckmans, Yani, Wouters, Roxanne, Laureano, Raquel S, Baert, Thais, Boon, Louis, Landolfo, Chiara, Testa, Antonia Carla, Fischerova, Daniela, Van Holsbeke, Caroline, Bourne, Tom, Chiappa, Valentina, Froyman, Wouter, Schols, Dominique, Agostinis, Patrizia, Timmerman, Dirk, Tejpar, Sabine, Vergote, Ignace, Coosemans, An, Garg, Abhishek D“…Biologically, we documented dominance of pro-tumorigenic, myeloid si-NFκB response(HIGH)si-IFN/ISG response(LOW) inflammation in periphery of patients with OV. Finally, in an orthotopic murine metastatic OV model, sFIS assay predicted the higher capacity of chemo-immunotherapy (paclitaxel–carboplatin plus anti-TNF antibody combination) in achieving a pro-immunogenic peripheral milieu (si-IFN/ISG response(HIGH)si-NFκB response(LOW)), which aligned with high antitumor efficacy. …”
Publicado 2021
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330218por Iezadi, Shabnam, Gholipour, Kamal, Azami-Aghdash, Saber, Ghiasi, Akbar, Rezapour, Aziz, Pourasghari, Hamid, Pashazadeh, Fariba“…Our search strategies in major databases yielded 12,523 results, which decreased to 7,540 articles after eliminating duplicates. Finally, 35 articles qualified to be included in the systematic review among which 23 studies were included in the meta-analysis. …”
Publicado 2021
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330219por Acharya, Arpan, Pandey, Kabita, Thurman, Michellie, Klug, Elizabeth, Trivedi, Jay, Sharma, Kalicharan, Lorson, Christian L., Singh, Kamal, Byrareddy, Siddappa N.“…Our data showed that mutation N501Y (present in B.1.351 variant) alters the binding mode of MU-UNMC-2 such that it is partially exposed to the solvent and has reduced polar contacts. Finally, MU-UNMC-2 displayed high synergy with remdesivir, the only approved drug for treating hospitalized COVID-19 patients. …”
Publicado 2021
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330220por Akter, Shamima, Shamrat, F. M. Javed Mehedi, Chakraborty, Sovon, Karim, Asif, Azam, Sami“…The proposed model required the least compilation time with 2 h, 50 min and 21 s. Finally, the Wilcoxon signed-rank test was performed to test the statistical significance. …”
Publicado 2021
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