“…Whilst, the AML-associated C/EBPα C-terminal mutant and N-terminal truncated mutant (C/EBPα-p30) diminished ULBP2/5/6 transcription. Finally, we identified that histone demethylase lysine-specific demethylase 1 (LSD1) inhibition can restore the expression of ULBPs via induction of CEBPA expression in AML cells, which may represent a novel therapeutic strategy for CEBPA-mutated AML. …”
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“…Specifically, after controlling for BMI, Bishop Score, and preeclampsia, leptin was still predictive of a failed IOL with an odds ratio of 0.47 (P = 0.046). Finally, using leptin as a predictor for fetal outcomes, leptin was also associated with of fetal intolerance of labor, with an odds ratio of 2.3 (P = 0.027). …”
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“…The variability in FMS™ means between studies was approximately five times greater in samples of secondary school children (factor difference in Tau values 5.16). The final meta-regression identified a negative association between BMI and FMS™ scores (r =  − 0.42), which signalled a moderate-to-large difference in FMS™ scores between healthy weight and overweight children/adolescents. …”
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“…The outcomes of the non-structured discussions were collected in Minutes of the TD and AoM meetings, and the final version was obtained with the consensus of all participants. …”
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“…The levels of IFN-γ, TNF-α, G-CSF, GM-CSF, EPO, and TPO in the peripheral blood were detected using enzyme-linked immunosorbent assay. Finally, the relationships between inflammatory factors and Mø subsets were analyzed. …”
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“…Age-standardized suicide ideation rates were reported, a binomial regression model was used to estimate suicide ideation indication rates for each country and measurement wave, and logistic regression models were then employed to relate sociodemographic, pandemic, and infodemic variables to suicide ideation. RESULTS: The final sample totaled 17,833 adults: 8806 (49.4%) from measurement wave 1 and 9027 (50.6%) from wave 2. …”
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“…At the same time Gr2 had a normal level of these factors (Fig, b, blue brackets). Finally, multiple cytokines and growth factors F3 were significantly increased in both AMI groups (Fig, b, d, red brackets). …”
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“…Outcome data were extracted from EMR at the first CGRP mAb prescription (index) and up to four assessments at ~3, 6, 9, and 12 months post-index. The final analyses were based on measures consistently reported in the EMR. …”
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“…At the end of the 70-day vaccination trial, 23 days post final boost, an intraperitoneal challenge with a field strain of Vibrio harveyi, V. alginolyticus, and V. parahaemolyticus was carried out. …”
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“…By the contribution to the subjective well-being of farmers and herdsmen, the six dimensions of social capital can be ranked as social network > social trust > social participation > social standard > social fame > common vision. (2) Individual social capital and collective social capital were mutually replaceable in terms of enhancing the subjective well-being of farmers and herdsmen; when the individual social capital was insufficient, the collective social capital would exert a much greater influence on the subjective well-being of farmers and herdsmen; when the individual social capital grows, the farmers and herdsmen would depend less on collective social capital. (3) The same amount of social capital contributes differently to the subjective well-being of farmers and herdsmen under different production models; by contribution strength, the production models can be ranked as pure herdsmen (PH) > pure farmers (PF) > non-farmers/herdsmen (NFH) > farmers + herdsmen (FH). Finally, several policy suggestions were provided to improve the subjective well-being of farmers and herdsmen in APTZ. …”
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“…METHODS: Among a total of 1169 sessions of gastric ESD performed in Kanagawa Cancer Center Hospital from 2006 to 2014, 179 sessions (15.3%) were performed in patients aged ≥ 80 years, and 172 of these sessions were done in patients with a final diagnosis of gastric cancer. These patients were studied retrospectively to evaluate short-term outcomes and survival. …”
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“…Notably, brain samples showed significantly more mtDNA deletions and at higher heteroplasmy percentages than blood samples, and several of the deletions present in the brain were not detected in the blood. Finally, mtDNA heteroplasmy, mtDNA CN and the deletion levels varied depending on the brain region studied. …”
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“…RESULTS: A total of 253 unique articles were identified, with seven studies, including 383 patients included in the final review. Of these seven studies, four describe treatment of both single and multiple neuromas in the same article, whilst three include only patients with multiple adjacent neuromas in the same foot. …”
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“…For each tendon defect, a copolymer construct was circumferentially wrapped around the defect and sutured into place. Finally, human cadaver testing was performed to assess implant handling and fixation characteristics. …”
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“…The Manchester-Oxford Foot Questionnaire (MOXFQ) at final follow-up, was the primary patient outcome measure.Complications were noted to be minor (superficial infection or delayed wound healing) or major (DVT/PE, deep infection, chronic regional pain syndrome (CRPS), arthrofibrosis, further intervention for post-traumatic arthritis, hardware failure or irritation). …”
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“…Complete ATFL injuries were determined by arthroscopy and CFL injuries were examined by magnetic resonance image. 26 ankles of which talar tilt angle was less than 9 degrees in ATFL and CFL complex injury group were excluded. Finally, 38 ankles with solitary ATFL injury and 31 ankles with ATFL and CFL complex injury were enrolled. …”
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“…Patients were screened and enrolled between September 2012 and June 2017 (with final follow-up in September 2017). Patients were randomized to treatment with IV thrombolysis with alteplase at 0.9 mg/kg body weight or placebo. …”
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“…RESULTS: The average age of the patients in our cohort was 63.3 (range, 39 - 83), with 42 patients in the psychotropic medication (MED) and 53 patients non-psychotropic medication (NO MED) cohorts. Mean time to final follow-up was similar between NO MED and MED groups (p=.987). …”
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“…Polytraumatized patients, open fractures and those with bilateral injuries were excluded. RESULTS: The final cohort included 190 ankles (52, 71, 67, for 2018, 2019, 2020 respectively). …”
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“…Patient-reported outcome measures were collected at final follow-up, with a minimum follow-up of 24 months. …”
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