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330481por Dubuc, J., Fauteux, V., Roy, J.-P., Denis-Robichaud, J., Rousseau, M., Buczinski, S.“…Overall, the number of exams assigned to each treatment was as follows: CON = 223 (25.6%), GnRH = 214 (24.6%), 2×GnRH = 220 (25.3%), and Resynch = 213 (24.5%). The final mixed multivariable logistic regression model included treatment, parity, days in milk at enrollment, and herd. …”
Publicado 2021
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330482“…The block run (i.e., fermentation day) effect influenced all of the fermentative and kinetic parameters. Greater final volumes or rates of gas production over time were observed for MDP compared with MTX rumen inocula (i.e., 172.6 vs. 147.8 mL/g of organic matter or 0.078 vs. 0.063 h(−1), respectively). …”
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330483por Delfosse, Antoine, den Brinker, Marieke, Gatto, Laurent, Gies, Inge, Lebrethon, Marie-Christine, Louis, Jacques, Lysy, Philippe, Martin, Manon, Mouraux, Thierry, Seret, Nicole, Polle, Olivier“…Interestingly, TIT and TAR remained close to values from Cluster 2 (55±11%; 23±10%). Finally, Cluster 4 demonstrated major hyperglycemias (TAR, 55±13%) with increased CV (47±9%) and decreased TBR (8±6%). …”
Publicado 2022
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330484por Livschitz, Jennifer, Elmir, Ezzeddine, Liu, Xuerong, Scotting, Oliver, Shaker, Joseph, Yen, Tina W, Wang, Tracy S, Evans, Douglas B, Edelstein, Adam I, Dream, Sophie“…RESULTS: Of 5215 patients identified, 269 (5%) were hypercalcemic. The final cohort included 495 patients (106 [21%] hypercalcemic cases, 389 matched controls). …”
Publicado 2022
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330485“…Thirty-three patients were included in the final analysis. The mean age was 63 (±7.8) years, 63.6% were male, and 87.9% had active MM or MM in remission. …”
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330486“…Backward binary logistic regression was used to assess the relationship between outcomes (follow-up attendance and readmission) and variables (including diagnosis and follow-up location) in the 62 patients with follow-up data. In the final models, a new diagnosis of DM was associated with follow-up attendance, and type 1 DM and follow-up nonattendance were associated with 30-day readmission. …”
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330487“…A month later she received a fourth/final dose of PEG-ASP 3,750 units which led to transient elevation of TGs peaking at 437 mg/dL but returning to levels below 200 mg/dl within two months. …”
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330488por Kim, Min-Ju, Kim, Min-Seon, Min, Se Hee, Na Jung, Han, Jung, Chang Hee, Kim, Ye-Jee“…Subgroup analyses were also conducted in patients with T2DM. RESULTS: The final cohort was composed of 285,119 participants with a mean age of 58.4 years and 55.2% of men. …”
Publicado 2022
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330489por Fazeli, Pouneh, Nawash, Baraa, Stockman, Sara, Ayinon, Caroline, Siegel, Lauren, Eljamri, Soukaina, Desai, Nikita“…Participants had a median BMI of 17.7kg/m 2 at the final menstrual period (FMP). Median age at the FMP in all low weight women with BMI<18.5kg/m 2 was 51 years. …”
Publicado 2022
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330490por Azmath, Misbah, Rivera, Luisa Bernacet, Bulsara, Ketan, Madhavan, Parvathy, Tendler, Beatriz“…Post-operative course was uneventful, he was started on empiric steroids which were tapered slowly. Final pathology of surgical specimen demonstrated epidermoid cyst, focal necrosis, lymphocytes and macrophages infiltration consistent with reactive granulation tissue. …”
Publicado 2022
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330491por Arora, Gunjan, Banjade, Rabin, Pethe, Gauri, Eshan, Shayet Hossain, Qureshi, Faisal“…INTRODUCTION: - COVID-19 pandemic hit the world in 2019 and with its advent, began a race against time to curtail its destructive aftermath, which finally seemed plausible with effective vaccination. …”
Publicado 2022
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330492por Thurston, Layla, Hunjan, Tia, Ertl, Natalie, Wall, Matt, Mills, Edouard, Suladze, Sofiya, Alexander, Emma, Muzi, Beatrice, Patel, Bijal, Bech, Paul, Goldmeier, David, Rabiner, Eugenii, Abbara, Ali, Comninos, Alexander, Dhillo, Waljit“…Furthermore, kisspeptin's deactivation of the secondary somatosensory cortex can reduce a woman's focus on herself, her body image, and related negative thoughts, thus augmenting her judgement of male facial attractiveness. Finally, kisspeptin's actions in the posterior cingulate cortex can serve to increase feelings of romantic love and reward processing, thereby reducing sexual aversion and increasing sexual desire. …”
Publicado 2022
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330493por Cannarella, Rossella, Caruso, Manuela, Condorelli, Rosita, Timpanaro, Tiziana, Vignera, Sandro L, Calogero, Aldo“…In the post-pubertal phase, these adolescents with insulin-resistance had lower TV compared to those with HOMA-index <2.5, while no difference was found in the other age ranges. Finally, T2DM did not influence TV in any age range. …”
Publicado 2022
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330494por Manshaei, Saba, Willis, Thea L, Reen, Virinder, Pallikonda, Husayn, Birch, Jodie, Withers, Dominic J, Gil, Jesus, Andoniadou, Cynthia L, Martinez-Barbera, Juan Pedro“…The differentiation failure can be rescued in vitro through co-culture of mutant cells with wild-type stem cells, as well as in vivo, in mutant pituitaries where activation of constitutively active BRF1 is restricted to few SOX2+ PSCs in a mosaic manner. Finally, we identify key ligands underlying this differentiation phenotype and demonstrate a partial restoration of terminal differentiation in the mutant, when cultured in the presence of these ligands. …”
Publicado 2022
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330495“…This coincided with increased expression of activating transcription factor 4 (ATF4), a main transcriptional regulator of amino acid uptake and metabolism, and downstream activation of amino acid genes as well as leucyl-tRNA synthetase (LARS), a putative leucine sensor. Finally, blocking mTORC1 using rapamycin did not reduce expression and activation of ATF4, suggesting that the latter does not act downstream of mTORC1. …”
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330496“…MRI abdomen showed extensive and diffuse infiltrative metastatic liver disease without evidence of pancreatic endocrine tumor. The final diagnosis was determined to be due to extensive tumor infiltration in the liver. …”
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330497por Azmath, Misbah, Bendaram, Snigdha, Igarashi, Yuichi, Aftab, Hassaan, Malchoff, Carl“…He was prepared for surgery with doxazosin 2 mg twice daily followed by metoprolol succinate and metyrosine up to 500 mg/d. Final pathology revealed a 5.3 cm left pheochromocytoma with negative surgical margins. …”
Publicado 2022
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330498por Korkmaz, Funda, Kuo, Tan-Chun, Gera, Sakshi, Sant, Damini, DeMambro, Victoria, Gumerova, Anisa, Sudha, Kathayani, Padilla, Ashley, Netto, Jessica, Sultana, Farhath, Miyashita, Sari, Shelly, Eleanor, Kumar, Pushkar, Burgess, Jocoll, Kannangara, Hasni, Muradova, Valeriia, Hutchison, Susan, Saxena, Mansi, Ryu, Vitaly, Kim, Se-Min, Meseck, Marcia, Goosens, Ki, Rosen, Cliff, Lizneva, Daria, Yuen, Tony, Zaidi, Mone“…We tested 215 variations of excipients using the protein thermal shift assay to generate a final formulation that rendered MS-Hu6 stable in solution upon freeze–thaw and at different temperatures, with minimal aggregation, and without self–, cross–, or hydrophobic interactions or appreciable binding to relevant human antigens. …”
Publicado 2022
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330499“…RESULTS: A total of 46,235 patients were included in the final study population, of whom 9,394 had a diagnosis of hypothyroidism. …”
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330500“…The ectodomain specifically is implicated in mediating GPNMB's effects on tumor growth. Finally, knocking out GPNMB in TSC2-null cells using CRISPR/Cas9 decreased xenograft tumor growth in mice. …”
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