“…Issues such as stability of reactants and products (particularly in water), kinetics, and unwanted side reactivity with biofunctionalities must be addressed, ideally guided by detailed mechanistic studies. Finally, the reaction must be tested in a variety of environments, escalating from aqueous media to biomolecule solutions to cultured cells and, for the most optimized transformations, to live organisms. …”
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“…MATERIALS AND METHODS: Among 55 newborns admitted between 1992-2008 with Meconium Related Ileus as final diagnosis, data about Low Birth Weight infants (LBW < 1500 g) were extracted and compared to those of patients ≥ 1500 g. …”
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“…Dosimetry and biodistribution studies were also performed. Finally, Kaplan-Meier survival analysis was performed for patients followed for greater than 12 months. …”
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“…We also identified a small number of countries scattered in different parts of the world that exhibit unusually low values of (4) q (1) relative to (1) q (0), a pattern that is not likely to arise merely from data errors. Finally, we illustrate that it is relatively common for populations to experience changes in age patterns of infant and child mortality as they experience a decline in mortality. …”
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“…After that, we incorporate probabilistic latent semantic indexing (PLSI) for feature reduction. Finally, the reduced features are used as input for a support vector machine (SVM) classifier. …”
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“…Meanwhile, SVM-REF is adopted to select the optimal features. Finally, SVM is applied to classify the four classes. …”
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“…In total, 435 participants provided a valid final weight at the 12-week follow-up. Intention-to-treat analyses (using multiple imputations) revealed that there were no statistically significant differences in weight loss between sites (P = .42). …”
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“…Then, a repository has been built based on such data model and structure, and deployed on distributed resources thanks to a Grid-based approach. Finally, data integration aspects have been addressed by providing the repository application with an efficient dynamic interface designed to enable the user to both easily query the data depending on defined datatypes and view all the data of every patient in an integrated and simple way. …”
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“…RESULTS: A total of 1529 (49.80%) participants completed final follow-up at 12 weeks. Retention was 73.11% (1123/1536) in the control arm and 26.47% (406/1534) in the intervention arm. …”
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“…The clinical impact in terms of hypoglycaemia and blood pressure was, however, modest. Finally, homozygous and heterozygous carriers of CYP2C9 variant alleles require lower doses of phenytoin to reach therapeutic plasma concentrations, and are at increased risk of toxicity. …”
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“…The benefit of “contract cases” is the guidelines require a complete clinical history, which should include selection of syndromes. Finally, selection was limited bovine submissions as was done in the pilot study. …”
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“…To analyse data, the diagnosis coded either in ICD10 for ED visits or with specific thesaurus for GP’s calls are pre-aggregated in about 200 syndromes covering a large part of the medical diagnosis and call reasons collected in the system. 22 age groups are also available with a focus on the most frailty population, like the youngest and the elderly. Finally, various geographic levels can be chosen, from the local ED or association to the national level. …”
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“…The criterion we use for re-weighting, here, is the value of the exceedance score. Finally, we investigate the validity of the upper threshold values based on the quasi-Poisson model when the data are generated using known negative binomial distributions. …”
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“…Visit diagnosis codes were identified for the top 10% of high utilizers, along with the date of admission, resident town, age, and gender. Finally, the top 10% over utilizers were mapped, identifying the total number of utilzers in each town. …”
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“…Most pilots implemented a CWS dashboard, in the form of a central graphical display, which presents the alerts and was used by the water utility and public health to obtain an understanding of geospatial relationships between cases, alerts and water pressure zones. Finally, public health and water utility representatives from several of the WSi pilots acknowledged that their automated surveillance tools currently have limited capabilities for detection of chemical contaminants (which may result in a sudden onset of symptoms), with the main deficiency being the timeliness of the alerts relative to the window of opportunity to respond in a meaningful and effective manner. …”
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“…FINDINGS: We report the final analysis of the trial. 62 eligible patients (39 with lung metastases) were included and analysed. 60 (98%, 95% CI 91–100) of 61 evaluable patients (one child underwent primary hepatectomy) had a partial response to preoperative chemotherapy. …”
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“…Significantly fewer Maackia amurensis leukoagglutinin positive goblet cells were noted in the conjunctiva of anakinra-treated eyes with a corresponding decrease in the expression of the pathological keratinization marker, SPRR1B. Finally, there was a downward trend in the infiltration of each immune cell type following anakinra treatment, but the cell counts compared to eyes treated with the vehicle alone were not significantly different. …”
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“…We advise that these uncertainties should be taken into account when setting the final Nordic recommendations.…”
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“…However, in both groups, means revealed a lower tendency to catastrophize pain before surgery as measured by the Pain Catastrophizing Scale (control group mean 1.04, SD 0.74; experimental group mean 1.10, SD 0.95) and after surgery (control group mean score 1.19, SD 0.94; experimental group mean score 1.08, SD 0.99). Finally, the experimental group consumed more opioid medication (mean 31.2 mg, SD 23.2) than the control group (mean 18.8 mg, SD 15.3, P  = .001). …”
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“…The grafts were removed and examined at days 10, 30, 60 and 100 following surgery. Finally, CD34 factor staining was used to identify endothelial cells, while light and electron microscopy were applied to examine endothelialization and patency. …”
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