“…The genetic code developed in three stages that are coincident with the refinement of the translation machines: the GNC code that was developed by the pre-tRNA/pre-aaRS /pre-mRNA machine, SNS code by the tRNA/aaRS/mRNA machine, and finally the universal genetic code by the tRNA/aaRS/mRNA/ribosome machine. …”
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“…Of these, meningiomas were finally diagnosed on brain MRI examination in six patients (M: F =3:3; age range: 30–66 years; and mean age: 45 years), with a prevalence of 1.2%. …”
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“…Only 4 signatures had homogeneous DOR and lower FPR when datasets with clinical diagnosis of ATB were included; other signatures either had heterogeneous DOR or higher FPR or both. Finally, 7 of 16 gene signatures predicted progression from LTBI to ATB 6 months prior to sputum conversion with positive predictive value > 6% at 2% prevalence. …”
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“…To this end, we provide a detailed, field-tested protocol to give mammalogists the tools to collect and preserve host and parasite materials that are of high quality and suitable for a range of potential downstream analyses (e.g., genetic, morphological). Finally, we also encourage increased global cooperation across taxonomic disciplines to build an integrated series of baselines and snapshots of the changing biosphere. …”
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“…The association of this signature with pathologic complete response was explored in 2 patient cohorts from different institutions, where all patients received HER2-targeted NAC (n = 28, n = 50). Finally, the association between significant peritumoral features and lymphocyte distribution was explored in patients within the BrUOG 211B trial who had corresponding biopsy hematoxylin-eosin–stained slide images. …”
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“…Meanwhile, neutralization of each TIMP-1, TIMP-2, or CXCL12 in vivo could reduce the left ventricular function at 1 and 4 weeks post-MI; importantly, the combined use of these three neutralizing antibodies could make a higher significance on cardiac function. Finally, blocking the CXCL12/CXCR4 axis with AMD3100 significantly reduced the left ventricular function and greatly inhibited Nestin(+) BMSC-induced CEC chemotaxis in vivo. …”
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“…In the SH group, 48.1% of patients normalized their TSH <4.2 in follow up (final TSH 3.4 [2.2,3.7]). For those patients immediately started on THR, 58 (50.4%) suppressed. …”
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“…He passed away at 12 y 1 mo due to complications from gastro-esophageal bleeding. During his final ICU admission, he required an insulin drip for glycemic management. …”
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“…An optimal hCG value was proposed as a predictor of pregnancy prognosis, comparing initial hCG values with the final outcome of the case. Cutoff values were proposed every 20 miU/mL from values of 80 mIU/mL up to 360 mIU/mL. …”
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“…Conclusion: The current study suggests that deleting adrenal Ar is sufficient to cause male adrenal phenotypic sex-reversal including retention of the X-zone. Finally, adrenal sexual dimorphism highlights the necessity to include both sexes in mouse adrenal studies and the mAdARKO model provides a novel model to determine the impact of sex on adrenal biology. …”
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“…Co-immunoprecipitation studies confirmed physical interaction between KLF15 and PPARδ. Finally, control and K15-SKO mice were gavaged with GW for 10 days, and K15-SKO animals demonstrated attenuated induction of a number of PPARδ targets in skeletal muscle. …”
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“…For NC, the cutoff point found was 38cm (S: 0.63 E: 0.70) and 42cm (S: 0.73 E: 0.59), for WC it was 101cm (S: 0.68 E: 0.73) and 108cm (S: 0.59 E: 0.70), for BMI it was 30.2 kg/m2 (S: 0.69 E: 0.66) and 32.4kg/m2 (S: 0.44 E: 0.75), for WLI it was 0.63 (S: 0.55 E: 0.60) and 0.66 (S: 0.90 E: 0.25) in women and men respectively. Finally we conclude that AP associated with the recent diagnosis of T2DM were: NC, BMI and WC, with the NC and WC being the parameters with the highest detection capacity for both sexes. …”
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“…Results: Of 77 WV who were called, 36 WV were assessed by the endocrinologist; 41 did not answer the phone and were regarded as the control. 8 WV from the intervention group and 16 WV from the control group did not have a follow-up HbA1c, and were excluded. 28 intervention and 25 control WV were included in the final analysis. In the intervention group: mean age 55.0 ± 10.3 years, BMI 29.8 ± 5.5, eGFR 57.9 ± 4.5, 86% type 2 diabetes, 61% on basal bolus insulin therapy, 68% HTN, 93% dyslipidemia, 71% smokers, 4% CAD, and 68% psychiatric diagnosis. …”
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“…After excluding patients with only post-operative PET scans and those with normal serum catecholamines and/or metanephrines, 205 patients were included in the final analysis. BAT activation was observed in 16 patients (7.8%; 28±17y; 10F/6M, 23.4±4.2 kg/m2). …”
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“…Western blotting assays were employed to evaluate the expression levels of proteins in the protein kinase B/mammalian target of rapamycin (Akt/mTOR) signaling pathway. Finally, in vivo activity of petasin was evaluated using the SW-620 subcutaneous tumor model established in Balb/c nude mice. …”
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“…Images were evenly split between the 2 classes, with 2457 smoking images (50.1%) and 2445 nonsmoking images (49.9%). The final model discriminated smoking vs nonsmoking environments with a mean (SD) AUC of 0.840 (0.024) (accuracy [SD], 76.5% [1.6%]). …”
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“…DESIGN, SETTING, AND PARTICIPANTS: This randomized clinical trial of the TECH-N intervention was conducted among female patients 13 to 25 years of age diagnosed with mild to moderate PID who were being discharged to outpatient treatment from September 6, 2012, to December 8, 2016, at a large academic medical center. The final analysis of data was completed in November 2018. …”
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“…In addition, our conclusions were established from a specific, highly selected population, so other study populations, such as women in an older age bracket, may yield different results. Finally, because we assessed day 2/3 transfers, our findings cannot be generalized to embryos cultured up to the blastocyst stage. …”
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“…In addition, only MIp showed unaltered single and double support periods, as well as stride length and cadence during single task self-selected gait condition. Finally, analysis showed that the improved MI ability score achieved at the end of MI training was significantly correlated with the changes in the strength of the operated leg (kinaesthetic imagery: r = 0.741, p = 0.004; and internal visual imagery: r = 0.623, p = 0.023). …”
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“…Fifth, we discuss the effect of physician financial incentives and program funding on the uptake of home dialysis. Finally, we introduce the controversial topic of comparing the societal value of freedom of modality choice against the societal cost savings of a “Home Dialysis First” policy. …”
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