“…Therefore, age was removed from the final model. We observed a significant main effect of group (p <.001); All patient groups were significantly impaired compared to the control group (CHR mean difference (MD) = 6.12; FEP MD = 16.46; CSz MD = 16.37; p <.001 in all cases), individuals with both FEP and CSz had significantly more cognitive impairment than the CHR group (FEP MD = 10.34; CSz MD = 10.25; p <.001 in both cases). …”
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“…Our study contributes to the identification of the epigenetic mechanisms involved in the neuropathophysiology of schizophrenia, which can bring new pharmacotherapeutic strategies and to identify biomarkers that can improve the early interventions in schizophrenia patients. Finally, our data thus reinforce the validity of rats reared in social isolation after weaning in modelling aspects of schizophrenia, highlighting the glutamatergic and GABAergic features involved principally in the cognitive impairments related to prefrontal cortex.…”
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“…Of note, mean RT discriminates the clinical groups better than ISV, thus emerging as a trans-diagnostic process to the three conditions and, uniquely for SCZ as a deficit independent of the specific tasks administered here. Finally, atypical microsaccadic frequency might suggest common abnormalities in motor response preparation in SCZ and ASD. …”
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“…Moreover, visual P300 amplitudes differentiated future psychosis converters after accounting for PRS symptom severity. Finally, both target P3b and novelty P3a amplitudes predicted the time to psychosis onset in PRS participants (p=.03 and p=.02, respectively), such that more deficient P300 amplitudes were associated with shorter time to conversion. …”
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“…Consistent with our third hypothesis, the beneficial effect of stress on metacognitive monitoring was smaller for HCs with high levels of APS, albeit not significantly so (r = -.28, p = .26). Finally, HR deceleration during VH presentation was significantly predictive of both SoA accuracy (F(1,12) = 13.3, p =.003, η²p = 0.53), and confidence in SoA judgments (F(1,12) = 10.64, p =.002, η²p = 0.52). …”
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“…Conversely, results from the literature on Attention-Deficit/Hyperactivity Disorder (ADHD) are more mixed, with some studies showing typical performance and others pointing out less efficient serial search in ADHD. Finally, most studies on visual search in Schizophrenia highlighted deficits in focal attentional processing. …”
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“…Logistic regression models were used to test if reason to start predicted different patterns of use. Finally, we used regression to test if Polygenic risk scores for schizophrenia (SZ PRS) explained variance in reasons to start. …”
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“…Clozapine-related constipation can develop into full-blown ileus in up to 2.1% of cases, a higher, more durable and more dangerous risk than agranulocytosis. Finally, hypertriglyceridemia and central obesity are well known cardiovascular risk factors. …”
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“…Then, DR-BUDDI was used to correct EPI distortions with input from the anatomical image and to combine the two datasets using geometric averaging to generate the final corrected dataset. Tensors were computed with DIFF_CALC using a linear fitting algorithm. …”
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“…IDTS had a more fluctuating course, with final values being modestly reduced to baseline (-10.7, p=0.127). …”
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“…We performed a systematic literature search on the following database: PyschInfo, Pubmed and Google Scholar. 1 2020 Congress of the Schizophrenia International Research Society Selection of the studies was conducted according to the following inclusion criteria: (a) empirical study, (b) quantitative measures of pragmatic comprehension of participants with SCZ, (c) sample including at least two individuals with SCZ (d) inclusion of a comparison group. Finally, 37 studies were identified as eligible for inclusion, and among these 27 studies provided enough data to be included in the meta-analysis. …”
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“…Only schizophrenia showed effects of critical timing of exposure to urban environment during infancy. Finally, we could not identify what exposures in the urban environment contributed to psychosis in our sample - although we could identify the etiological factors that did not. …”
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“…Due to mediation analysis, we further gained insights into the hierarchy of these variables’ impact on clozapine prescription and we finally compose a complex network of proximal and distal factors predicting clozapine exposure in schizophrenic patients. …”
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“…Information on mortality was conducted in collaboration with the SEADE, the center of São Paulo State Government in production of socioeconomic and health data, and December 2016 was the final point of the survival time. Diagnosis and mortality cause were coded according to ICD-10. …”
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“…We also explored whether baseline clinical and demographic characteristics were predictors of relapse. Finally, we report the results of patients from the open-label, crossover phase of the study. …”
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“…A subsequent in vitro analysis with primary cultured GCs and COCs was used to confirm the influence of metformin on ER stress activation by qPCR and western blot. Finally, the effects of ER stress activation on GCs and COCs in relation to LH responsiveness were examined by qPCR and COC expansion. …”
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“…RESULTS: Between day 20 and 30 of lockdown, 538 parents responded to the survey, and we included 533 responses in the final analysis. The vast majority of responders were women 95 % (95 % CI 93,50; 97,18) with children whose mean age was 10,5 (95 % CI 7.58; 13.44). …”
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“…We used generalized estimating equations to estimate changes in outcomes. RESULTS: The final sample consisted of 229 patients. Participants were 61.6% (141/229) male, had a mean age of 62.9 years, mean glycated hemoglobin (HbA(1c)) of 7.5%, mean BMI of 32.7, and a mean duration of T2D diagnosis of 9.8 years. …”
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“…Ayurvedic medicine exploits the power of the mind based on beliefs and traditions as a means for healing from illnesses. Finally, the third topic is a search for the meaning to the phrase “Pointing the finger at the Moon,” and leading to the discovery of a three-dimensional holographic image on the Moon. …”
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“…The best model that comprised only robotic parameters (the 20 parameters identified in the final model) achieved a better performance than the clinical parameters alone, but worse than the combination of both clinical and robotic variables (ROC AUC: 0.73, 95% CI 0.63–0.83). …”
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