“…While no longer powered to assess Day 141 primary endpoint (PE), the study permitted placebo-controlled evaluation of safety and efficacy. The final analysis included 41 patients in the cimdelirsen low dose (60 and 80 mg; n=22), high dose (120 and 160 mg; n=7) or placebo (n=12) cohorts. 39 of these patients subsequently entered an open label extension (OLE) safety study where all patients were treated with cimdelirsen and at the time of interim analysis, 23 patients were treated for ≥ 1 year (NCT03967249).Patient reported outcomes were assessed using the validated ACROQoL and an acromegaly symptoms questionnaire. …”
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“…Similarly, IGF2 incubation downregulated FSHR mRNA (-27.1% at 0.33 ng/mL, -45.4.2% at 3.33 ng/mL, -21.1%, respectively, p<0.01) and protein (for both WB and IM) expression. Finally, SC proliferation significantly decreased after incubation with IGF2 (2.82±0.1% in untreated controls, -1.87±0.1% at 0.33 ng/mL, -2.19±0.2% at 3.33 ng/mL, and -2.36±0.1% at 10 ng/mL; p<0.01). …”
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“…PET confirmed widespread multifocal FDG hypermetabolic lesions. Final diagnosis of ECD was made; he was started on targeted therapy with Vemurafenib, a BRAF inhibitor. …”
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“…Next, we combined optogenetic activation of MePD Ucn3 neurons with pharmacological antagonism of GABAA or GABAB receptors with bicuculline or CGP, respectively, and observed the effect on LH pulsatility. Finally, during optical activation of MePD Ucn3 neurons we administered a combination of NMDA and AMPA receptor antagonists, AP5 and CNQX respectively, and monitored the effect on pulsatile LH secretion. …”
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“…No difference was observed in the lipid profile (e.g., total cholesterol, triglycerides, phospholipids and free fatty acids) of WT and MT1KO mice under CD, while HFD significantly increased the cholesterol (149.5 vs 225.2 mg/dL, P<0.05) and phospholipids (287.8 vs. 358.6 mg/dL P<0.05) levels in MT1KOs. Finally, HFD leads to a significant increase in lipid deposition in the liver of MT1KOs when compared to other groups (34.46 vs 54.88 mg/g tissue, P<0.05). …”
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“…Median follow-up time was 10 years. Median final adult height (height z-score) for females was 159.5 cm (-0.53) (IQR1-IQR3: 152.4,160.3cm; height z-score: -1.68, -0.47) and for males 167.5cm (-1.3) (IQR1-IQR3: 161.5, 171cm; height z-score: -2.13, -0.81). …”
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“…At 1-month follow-up after RFA all TN were fibrosed and no lymph node or distant metastases were found. Finally, in both groups, no major complications were found and only one patient reported ecchymosis at the puncture site. …”
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“…CIBERSORT analysis revealed that CHI3L1 and PIP high tumors had altered immune profiles, including differential macrophage levels. Finally, CHI3L1 and PIP treatment significantly reduced macrophage efferocytosis of BC cells (p ≤ 0.0001). …”
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“…Because we did not estimate years of life lost associated with benign prostatic hyperplasia, disability-adjusted life-years (DALYs) equalled YLDs. The final estimates were compared across Socio-demographic Index (SDI) quintiles. …”
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“…Also, various reasons for conversion to arthroplasty were pooled in this study, but the separate prediction of underlying pathology (such as, avascular necrosis or nonunion) may be more precise. Finally, it may be possible that it is inherently difficult to predict conversion to arthroplasty based on preoperative variables alone. …”
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“…After the OFAR closed to enrollment, all investigators of the OFAR consortium, including those who were not able to participate as a site, were surveyed to investigate the barriers they faced when launching OFAR at their site. RESULTS: The final OFAR database includes 1,675 procedures performed at four institutions, with 1,126 having complete data for analysis. …”
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“…Evidence of loosening was higher in the Infinity group at 5-years compared to Salto and STAR (1 Infinity, 0 Other, p<0.05). Finally, more lucency zones were identified at 3 months in Infinity group compared to Salto and STAR (p<0.05). …”
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“…The insole also identified tendon load changes according to patient instructions, including a 65% increase in peak load by intentionally 'trying to push off' during gait. Finally, tendon load rates and impulse strongly correlated with peak load (R2 >0.85). …”
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“…All returning subjects who provided consent were evaluated with computed tomography (CT) scans, American Orthopaedic Foot & Ankle Society (AOFAS) Scores, Foot Pain and Disability (FFI) Scores, and visual analog scores (VAS) assessing fusion site, weight bearing, and graft harvest site pain. Because final fusion status was dependent upon the status exiting the original trial, maintenance or improvement of fusion status was the key focus of the study. …”
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“…Except for macrophage M1 genes IRF5 and PTGS2, MAP1A expression was significantly correlated with the gene levels in immunocytes such as CD4(+) T cells, CD8(+) T cells, B cells, dendritic cells (DCs), macrophages, and neutrophils (Cor > 0.2, P < 0.001), as well as immune checkpoint related genes including cytotoxic t-lymphocyte-associated protein 4 (CTLA-4), programmed death 1 (PD-1), programmed death ligand 1 (PD-L1) (P < 0.001). Finally, we predicted that the MAP1A-interacting miRNA was miR-34a-5p, and the MAP1A endogenous competing RNAs were LNC00667, circ_MAP1B, and circ_MYLK, respectively. …”
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“…Nineteen RCTs (1316 patients) were included in the final analysis. The mean number of patients per study treatment arm was 35 +- 16, mean age was 41 +- 5 years, mean sex composition was 80% +- 10% males, and mean follow-up was 22 +- 12 months. …”
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“…These patients were screened for end-stage ankle arthritis (Grade 3 or 4 on Kellgren-Lawrence Classification) and 509 patients were included in the final sample. For the primary variables of interest, patients were grouped by race (White/ Non-white), ethnicity (Hispanic/ Non-Hispanic), and primary spoken language (English/ non-English). …”
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“…Similarly, among the subsets of CD4(+) T cell, a relatively higher level of mitochondrial metabolism was noted for naive CD4(+) T cells. Finally, from the CD8(+) T cell subsets, CD8(+) Tcm had relatively high levels of MM and MMP but relatively low ones for mitophagy, with effector T cells displaying the opposite characteristics. …”
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“…Implant material is composed of continuous reinforcing mineral fibers (SiO2, Na2O, CaO, MgO, B2O3, and P2O5), bound together by a degradable polymer [poly (L-lactide-co-D,L-lactide), PLDLA]) in a 50% w/w ratio. Final study visit took place two years post-operatively. …”
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“…The signature was then tested by GSE132342 data. Finally, the clinicopathological characteristics of TCGA-OV were screened by univariate and multivariate Cox regression analysis to draw the nomogram. …”
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