“…We have also shown that immuno-oncological proteins isolated from pre-ICIs treated patients were significantly higher in exosomes compared to their soluble-free counterparts (CD152, p=0.0008; CD80, p=0.0182; IDO, p=0.0443; Arginase, p<0.0001; Nectin-2, p<0.0001; NT5E, p<0.0001; Siglec-7, p<0.0001; Siglec-9, p=0.0335; CD28, p=0.0092; GITR, p<0.0001; MICA, p<0.0001). Finally, the changes in the expression levels of exosomal immuno-oncological proteins/cytokines and their correlation with tumor response to ICIs treatment were assessed. …”
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“…Participants included residents of Olmsted County, Minnesota, diagnosed with breast cancer or lymphoma from January 1985 through December 2010 matched for age, sex, and comorbidities with healthy controls, with a final ratio of 1 case to 1.5 controls. Statistical analysis was performed between July 2017 and February 2022. …”
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“…METHODS: For the synthesis of the biofertilizer, both strains were added to the ORGAON(®) organic matrix separately, until reaching a final optical density (OD) of 0.5 McFarland in each case in the irrigation matrix. …”
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“…These results were consistent when evaluating hospitalization as the outcome and also when stratifying by race and sex. Finally, a sensitivity analysis evaluating specific IS revealed that TNF inhibitors were protective against life-threatening disease (OR = 0.80, 95% CI 0.66- 0.96; p=1.66E-2) and hospitalization (OR = 0.80, 95% CI 0.73 - 0.89; p=1.06E-05). …”
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“…RESULTS: 8 RCTs were finally included in this study, including 2470 patients with HER2-negative metastatic breast cancer. …”
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“…The independent methods of hierarchical cluster analysis and k-means were used to classify parameters according to their r values. Finally, network analysis provided a 3-dimensional view of the results. …”
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“…Thus, these symptoms relate to being a female aged between 18 and 38 and originating from Mexico. Finally, the possibility of screening the migrant population for signs and symptoms of mental health conditions that attended the Health Windows or Mobile Health Units during 2021, made it possible to refer them to psychology or psychiatry services and improve the quality of life of those who accessed the services and, consequently, that of their families and communities. …”
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“…Petersburg Sleep Quality Questionnaire was completed by both groups at the beginning and 4 weeks after the start of the intervention. Finally, the data were analyzed by SPSS software version 22 and independent t-test, paired t-test and Chi-square test. …”
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“…The results were presented and analyzed by weighted mean difference (WMD), Standard Mean Difference (SMD) and risk ratio (RR) at their 95% confidence interval (CI). Finally, the limitations of this study are analyzed in order to provide a more objective view of the results of this study. …”
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“…On the other hand, the most sensitive mRNA for differentiating CSA from control is mRNAs (PIK3C2A + TXNIP) (0.963; p < 0.001; 95), then TXINP (81.3; p < 0.001; 93.33), and finally, PIK3C2A (0.782; p < 0.001; 81.67). In the multivariate regression model, PIK3C2A ((p = 0.002), 0.118 (0.031–0.445)) and smoking status ((p = 0.034); 0.151 (0.026–0.866)) were independent variables for ACS. …”
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“…The cost outcome was defined as the average per capita cumulative healthcare direct costs of the treatment, including all inpatient and outpatient costs. Results: The final cohort included 177 patients, of whom 58 were treated with systemic treatment plus aRT (STRT) and 119 with systemic treatment alone. …”
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“…In the assay investigating the radiopeptide susceptibilities against serum peptidase degradation, the EGBP-based agent demonstrated a limited stability with a half-life of only 66.4 ± 3.0 min, whereas the other tracers showed considerably higher stabilities of up to an 8000 min half-life. Finally, all radiotracer candidates were evaluated in terms of tumor cell internalization and receptor binding potential on EGFR-positive A431 cell. …”
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“…Compared with hot reflux extraction and ultrasonic extraction methods, MSPD has the advantages of combined extraction and purification, being less time-consuming, and requiring lower solvent volumes. Finally, the optimized method was successfully applied to analyze five lignans from Schisandra chinensis samples from 17 cultivation areas.…”
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“…Furthermore, the mean post-op VA between pre and post-op VA was significantly different (p<0.001), with a 95% CI of mean difference (-0.85, -0.28). Finally, there is a significant factor association between the duration of ERM and post-op VA (b=.023, 95% CI .001, .05, p<0.05) with our patients. …”
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“…Statistical methods used were χ² test, independent samples t-test and Pearson correlation analysis were. Finally, we controlled for confounding factors and used logistic multi-factor regression analysis. …”
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“…The density functional theory (DFT) analysis was used to evaluate compound chemical reactivity, which was determined by calculating the frontier orbital energy of both HOMO and LUMO orbitals, as well as the HOMO–LUMO energy gap. Finally, the QiKProp module was used for ADME-T analysis. …”
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“…Regardless of the complexity of the underlying physics scenario the basic objects that compose the observable final state are just a few: photons, electrons, muons, light hadrons generally grouped in jets, secondary vertices that provide heavy flavor tagging and missing transverse energy that hints at an invisible particle that did not interact in the detector (or at a malfunctioning calorimeter). …”
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“…The digitisation, reconstruction and analysis of the events was performed using softwares specific for CMS experiment. The final state in this channel is a set of quark-jets in the forward and backward rapidity region and b-jets in the central region. …”
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“…I describe the official LHCb analysis of B^{\pm}-> D^0 K^{\pm} decays that I have repeated during my training period, as well as the computing techniques used. Finally I describe the first reconstruction attempts for B^{\pm}-> D^{*0}h^{\pm} channels. …”
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“…Rutherford backscattering and channeling spectrometry (RBS/C), X-ray diffraction (XRD) and deep level transient spectroscopy (DLTS) - followed by emission channeling (EC) and ab initio calculations, which aim at studying the lattice location of implanted impurities. Finally, chapter 5 contains a short summary and a discussion of the results that have been obtained within the framework of this research. …”
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