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  1. 331581
    “…RESULTS: Of the 2660 potentially eligible studies, a total of 31 studies (22 retrospective and 9 prospective cohort studies) were included in the final analysis. Eventually, the high-quality evidence confirmed that SSI was correlated with obesity (RR = 1.60, 95% confidence interval (CI): 1.47–1.74), ASA score ≥3 (RR = 1.34, 95% CI: 1.19–1.51), and emergent surgery (RR = 1.36, 95% CI: 1.19–1.55). …”
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    Risk factors for surgical site infection in patients undergoing colorectal surgery: A meta-analysis of observational studies
  2. 331582
    “…Of the 6 that failed to return to play after surgery, 3 reported that persistent elbow symptoms were the reason for not returning to play while the other 3 reported losing the desire to return to play. At final follow-up, 7 (31.8%) patients reported of persistent sensory ulnar nerve sensory symptoms while 1 (4.5%) of these patients additionally reported persistent ulnar nerve motor symptoms. …”
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    Return to Play Rates and Clinical Outcomes of Baseball Players Following Concomitant Ulnar Collateral Ligament Reconstruction and Indicated Ulnar Nerve Transposition (130)
  3. 331583
    por Pinato, David J, Tabernero, Josep, Bower, Mark, Scotti, Lorenza, Patel, Meera, Colomba, Emeline, Dolly, Saoirse, Loizidou, Angela, Chester, John, Mukherjee, Uma, Zambelli, Alberto, Dalla Pria, Alessia, Aguilar-Company, Juan, Ottaviani, Diego, Chowdhury, Amani, Merry, Eve, Salazar, Ramon, Bertuzzi, Alexia, Brunet, Joan, Lambertini, Matteo, Tagliamento, Marco, Pous, Anna, Sita-Lumsden, Ailsa, Srikandarajah, Krishnie, Colomba, Johann, Pommeret, Fanny, Seguí, Elia, Generali, Daniele, Grisanti, Salvatore, Pedrazzoli, Paolo, Rizzo, Gianpiero, Libertini, Michela, Moss, Charlotte, Evans, Joanne S, Russell, Beth, Harbeck, Nadia, Vincenzi, Bruno, Biello, Federica, Bertulli, Rossella, Liñan, Raquel, Rossi, Sabrina, Carmona-García, Maria Carmen, Tondini, Carlo, Fox, Laura, Baggi, Alice, Fotia, Vittoria, Parisi, Alessandro, Porzio, Giampero, Saponara, Maristella, Cruz, Claudia Andrea, García-Illescas, David, Felip, Eudald, Roqué Lloveras, Ariadna, Sharkey, Rachel, Roldán, Elisa, Reyes, Roxana, Earnshaw, Irina, Ferrante, Daniela, Marco-Hernández, Javier, Ruiz-Camps, Isabel, Gaidano, Gianluca, Patriarca, Andrea, Bruna, Riccardo, Sureda, Anna, Martinez-Vila, Clara, Sanchez de Torre, Ana, Cantini, Luca, Filetti, Marco, Rimassa, Lorenza, Chiudinelli, Lorenzo, Franchi, Michela, Krengli, Marco, Santoro, Armando, Prat, Aleix, Van Hemelrijck, Mieke, Diamantis, Nikolaos, Newsom-Davis, Thomas, Gennari, Alessandra, Cortellini, Alessio
    Publicado 2021
    “…After the exclusion of ineligible patients, the final study population consisted of 2634 patients. 1557 COVID-19 survivors underwent a formal clinical reassessment after a median of 22·1 months (IQR 8·4–57·8) from cancer diagnosis and 44 days (28–329) from COVID-19 diagnosis. 234 (15·0%) patients reported COVID-19 sequelae, including respiratory symptoms (116 [49·6%]) and residual fatigue (96 [41·0%]). …”
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    Prevalence and impact of COVID-19 sequelae on treatment and survival of patients with cancer who recovered from SARS-CoV-2 infection: evidence from the OnCovid retrospective, multicentre registry study
  4. 331584
    “…If the potentially predictive demographic characteristic maintained trends toward significance (p<0.1), the predictor was retained in the model to produce the final regression results for each outcome. Results: Hospitalized COVID patients were predominantly male, obese (BMI 30.6) and average age was 63 years. 69.3% of patients were Hispanic. 65.51% of patients were diabetic, 26.27% had chronic kidney disease and 23.10% had congestive heart failure. …”
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    COVID-19 Pandemic Highlights Health Disparities in Latinos in San Diego
  5. 331585
    “…In addition, based on our findings that γH2AX clusters associated with heterochromatin show a high degree of similarity independently of dose and repair time, these earlier published topological analyses and similarity calculations comparing repair foci within individual cells were extended by topological data averaging (2nd-generation heatmaps) over all cells analyzed at a given repair time point; thereby, the two dimensions (0 and 1) expressed by components and holes were studied separately. Finally, these mean value heatmaps were averaged, in addition. …”
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    Topological Analysis of γH2AX and MRE11 Clusters Detected by Localization Microscopy during X-ray-Induced DNA Double-Strand Break Repair
  6. 331586
    “…In addition, increased immunostaining of cell proliferation markers, Ki-67 and PCNA, was observed in bronchiolar epithelial cells and hyperplastic pneumocytes in mouse lungs at day 7 and day 42 after Nano-Ni exposure. Finally, using gpt delta transgenic mice revealed that Nano-Ni exposure did not cause increased gpt mutant frequency and certain DNA mutations, such as base substitution and small base insertions/deletions, are not the main types of Nano-Ni-induced DNA damage. …”
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    Nickel nanoparticle-induced cell transformation: involvement of DNA damage and DNA repair defect through HIF-1α/miR-210/Rad52 pathway
  7. 331587
    “…Une corticothérapie générale (CTG, 1 mg/kg/j, 50 mg/j) associée à de la doxycycline 200 mg/j était débutées, permettant une régression quasi complète mais avec rechute à la baisse de 15 à 10 mg/j, puis échec de CTG à 0,8 mg/j + hydroxychloroquine. Finalement du méthotrexate 10 mg/semaine était débuté avec régression complète de l’œdème. …”
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    Granulomatose faciale 38 ans après des injections de produits de comblement : rôle précipitant de la COVID-19 et intérêt du méthotrexate
  8. 331588
    “…Step 1b of the UK national lockdown easing was sufficient to precipitate exponential growth in B.1.617.2 cases for most regions and younger adult age groups. The final stages of NPI easing appeared to have a negligible impact on the growth of B.1.617.2 with every region experiencing sustained exponential growth from step 2. …”
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    Growth, reproduction numbers and factors affecting the spread of SARS-CoV-2 novel variants of concern in the UK from October 2020 to July 2021: a modelling analysis
  9. 331589
    por Gerges, B, Li, W, Leonardi, M, Mol, B W, Condous, G
    Publicado 2021
    “…MAIN RESULTS AND THE ROLE OF CHANCE: There were 1977 references identified from which 10 studies (n = 1188) were included in the final analysis. For the detection of USL DE, the overall pooled sensitivity and specificity for all TVS techniques were 60% (95% CI 32–82%) and 95% (95% CI 90–98%), respectively, and for all MRI techniques were 81% (95% CI 66–90%) and 83% (95% CI 62–94%), respectively. …”
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    Meta-analysis and systematic review to determine the optimal imaging modality for the detection of uterosacral ligaments/torus uterinus, rectovaginal septum and vaginal deep endometriosis
  10. 331590
    “…Furthermore, the expression levels of 8 m(6)A regulators and 12 m(6)A-related ncRNAs were significantly different between the two groups. Finally, this risk model could be used to predict immunotherapeutic responses. …”
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    N6-methyladenosine-related non-coding RNAs are potential prognostic and immunotherapeutic responsiveness biomarkers for bladder cancer
  11. 331591
    por Snyder, Thomas M, Gittelman, Rachel M, Klinger, Mark, May, Damon H, Osborne, Edward J, Taniguchi, Ruth, Jabran Zahid, H, Elyanow, Rebecca, Dalai, Sudeb C, Kaplan, Ian M, Dines, Jennifer N, Noakes, Matthew T, Pandya, Ravi, Baldo, Lance, Semprini, Simona, Cerchione, Claudio, Nicolini, Fabio, Mazza, Massimiliano, Delmonte, Ottavia M, Dobbs, Kerry, Laguna-Goya, Rocio, Carreño-Tarragona, Gonazalo, Barrio, Santiago, Imberti, Luisa, Sottini, Alessandra, Quiros-Roldan, Eugenia, Rossi, Camillo, Biondi, Andrea, Bettini, Laura Rachele, D’Angio, Mariella, Bonfanti, Paolo, Tompkins, Miranda F, Alba, Camille, Dalgard, Clifton, Sambri, Vittorio, Martinelli, Giovanni, Goldman, Jason D, Heath, James R, Su, Helen C, Notarangelo, Luigi D, Paz-Artal, Estela, Martinez-Lopez, Joaquin, Carlson, Jonathan M, Robins, Harlan S
    Publicado 2021
    “…Applying these data, we trained a classifier to diagnose past SARS-CoV-2 infection based solely on TCR sequencing from blood samples and observed, at 99.8% specificity, high sensitivity soon after diagnosis (Day 3–7 = 85.1%; Day 8–14 = 94.8%) that persists after recovery (Day 29+/convalescent = 95.4%). Finally, by evaluating TCRs binding epitopes targeting all non-spike SARS-CoV-2 proteins, we were able to separate natural infection from vaccination with > 99% specificity. …”
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    126. Magnitude and Dynamics of the T-Cell Response to SARS-CoV-2 Infection and Vaccination
  12. 331592
    “…CT findings, combined with laboratory results, can support the diagnosis of HAS. However, the final diagnosis needs to be confirmed with a histopathologic examination. …”
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    Computed Tomography Features and Clinical Prognostic Characteristics of Hepatoid Adenocarcinoma of the Stomach
  13. 331593
    “…The remaining intact ligaments of each subgroup were similarly randomized for transection (e.g., group 6ac: transection of the first tarsometatarsal joint, followed by transection of the intercuneiform ligament). Finally, the last ligament was transected (group 7). …”
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    Change in the C1-M2 Distance after Simulated Purely Ligamentous Lisfranc Injury as Evaluated by Weightbearing CT Scans: A Match-Paired Cadaveric Study
  14. 331594
    “…These biological effects were validated in cells overexpressing or knocked-down for miR-210-3p. Finally, we showed that miR-210-3p inhibits pancreatic tumor growth and proliferation in vivo. …”
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    Antagonistic Roles of the Tumor Suppressor miR-210-3p and Oncomucin MUC4 Forming a Negative Feedback Loop in Pancreatic Adenocarcinoma
  15. 331595
    “…CBC variables included in final BF model were temporally parsed in 24h intervals then pooled when measured after 120h since first vital sign at hospitalization. …”
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    Complete Blood Count Parameters Outperform Putative Inflammatory Markers in Predicting COVID-19 Mortality: A Multimodal Machine Learning Model
  16. 331596
    “…The primary endpoint was viral suppression at 12 months (with a 6 month final measurement window [ie, 9–15 months]), defined as less than 1000 HIV RNA copies per mL, with a non-inferiority margin of 5%. …”
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    Rates of viral suppression in a cohort of people with stable HIV from two community models of ART delivery versus facility-based HIV care in Lusaka, Zambia: a cluster-randomised, non-inferiority trial nested in the HPTN 071 (PopART) trial
  17. 331597
    “…RESULTS: Total 2040 patients were enrolled and 1815 (mean age 60.6 years, 50.2% men) finally included. LV was chosen by 52% of patients (50.8% of men, 54.9% of women). …”
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    Efficacy and tolerability of high and low-volume bowel preparation compared: A real-life single-blinded large-population study
  18. 331598
    “…ApoE (-/-) augmented pro-atherogenic/inflammatory and antigen-presenting cells (APC) feature in both subsets due to elevated expression of cytokine genes (Cxcl11, Cntf, Il24, Xcl, Ccr5, Mpl, and Acvr2a) and MHCII gene (H2-Aa and H2-Ea-ps). Finally, we modeled immunological gene expression changes and functional implications in MC differentiation and adaptive immune response for MC subsets from control and ApoE(-/-) mice. …”
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    Adaptive Immune Response Signaling Is Suppressed in Ly6C(high) Monocyte but Upregulated in Monocyte Subsets of ApoE (-/-) Mice — Functional Implication in Atherosclerosis
  19. 331599
    “…We assessed the experimental quality, patient phenotype assessment and functional evidence based on gene expression, mutant in-vitro cell and in-vivo animal model phenotypes. A final score was used to determine the clinical validity of each GDR, across the following five categories: no evidence, limited, moderate, strong or definitive. …”
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    A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene–disease relationships
  20. 331600
    “…The primary analysis consisted of a survival analysis of time to change in glycemic status at or prior to the final patient visit, which occurred at varying times after 12 months for each patient. …”
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    Effects of a Lifestyle Intervention to Prevent Deterioration in Glycemic Status Among South Asian Women With Recent Gestational Diabetes: A Randomized Clinical Trial
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