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  1. 331641
    “…The most common cinnamic acid derivatives are p-coumaric acid, caffeic acid, and ferulic acid. On the one hand, according to the above information and the different positions and degree of quinic acid esterification, the CGAs were structurally classified as monosubstituted CGAs (Mono-CGAs), disubstituted CGAs (Di-CGAs), and trisubstituted CGAs (Tri-CGAs), and three different mass defect filtering windows were set. …”
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    超高效液相色谱-高分辨质谱联用结合整合过滤策略全面分析茶树花中化学成分
  2. 331642
    por LIU, Luyao, QIN, Hongqiang, YE, Mingliang
    Publicado 2021
    “…Automated analysis of MS data of intact N- and O-glycopeptides requires interpretation approaches and corresponding software tools with high sensitivity and reliability. Finally, we highlight the utility of several spectral interpretation approaches and their corresponding popular search software, including ArMone, Byonic, GPQuest, pGlyco, O-search, MSFragger-Glyco, and O-Pair Search. …”
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    完整糖基化肽段的富集与质谱解析新技术研究进展
  3. 331643
    “…The optimization principles and research progress on optical absorption detection are briefly introduced. Finally, commercial nano liquid chromatographic systems are compared by considering the pumps and injectors.…”
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    纳升液相色谱仪器的研究进展
  4. 331644
    “…The urban-rural difference was highest for South Asia (7.50%, 95% CI, 5.73, 9.26), followed by sub-Saharan Africa (4.24%, 95% CI, 2.62, 5.86) and reversed for Europe and Central Asia (−6.04%, 95% CI, −9.06, −3.01), in the period 1990 to 2020, p < 0.001 for region. Finally, the urban-rural difference in hypertension prevalence decreased nonlinearly with improvements in Human Development Index and infant mortality rate. …”
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    Urban-rural differences in hypertension prevalence in low-income and middle-income countries, 1990–2020: A systematic review and meta-analysis
  5. 331645
    “…The adjusted HR for in-hospital mortality was 8·24 (95% CI 2·16–31·36, p=0·0019) in patients who received no dexamethasone treatment, but 2·27 (0·69–7·55, p=0·18) in those who received dexamethasone after the scan, suggesting that vascular inflammation might have been a therapeutic target of dexamethasone in COVID-19. Finally, C19-RS was strongly associated (r=0·61, p=0·00031) with a whole blood transcriptional module representing dysregulation of coagulation and platelet aggregation pathways. …”
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    Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19
  6. 331646
    por Tu, Minghui, Zhang, Aiming, Hu, Li, Wang, Feng
    Publicado 2022
    “…The incidence of hepatic vein occlusive disease in the study group was higher, and the difference between groups was statistically significant (P < 0.05). Finally, we compared the incidence of adverse reactions. …”
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    A Retrospective Cohort Study of the Efficacy, Safety, and Clinical Value of 6-TG versus 6-MP Maintenance Therapy in Children with Acute Lymphoblastic Leukemia
  7. 331647
    “…After internally validating the algorithm using stratified tenfold cross-validation, we incorporated a conformal prediction framework to tag patients with erroneous data or distribution shifts. We finally externally validated KIDMATCH on patients with MIS-C enrolled between April 22, 2020, and July 21, 2021, from Boston Children's Hospital (MA, USA), Children's National Hospital (Washington, DC, USA), and the CHARMS Study Group consortium of 14 US hospitals. …”
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    A machine-learning algorithm for diagnosis of multisystem inflammatory syndrome in children and Kawasaki disease in the USA: a retrospective model development and validation study
  8. 331648
    “…Four samples were collected from each station including dry sand collected from the middle of the dry sand section of the shore; wet sand comprising coastline areas sand and the shallow part (20 cm in depth) of seaboard ∼ 1m toward the seawater; and finally, water sample which was gathered from the shoreline. …”
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    P069 Caspian Sea Mycobiome: The variety and abundance of medically important fungi in beach sand and water
  9. 331649
    “…EGPA is characterized by a prodrome of asthma and allergic rhinitis, followed by peripheral blood hyper-eosinophilia and accumulation of extravascular eosinophils, and finally systemic vasculitis. Extra-pulmonary involvement is common, sometimes with fatal outcomes. …”
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    P41 Spotting the needle amongst the haystack - when asthma isn’t asthma
  10. 331650
    por Patel, Fahim
    Publicado 2022
    “…Such cases are more numerous and predate those associated with the constitutional form. The final common pathogenesis is thought to be activation of the NF-κB pathway. …”
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    OA25 Constitutional trisomy 8 mosaicism is associated with a paediatric incomplete Bechet’s-like phenotype
  11. 331651
    “…The maker peptide “EAYNGLPAK”, which characterized the svTLE from Bothrops atrox, was finally screened and validated by comparison of the basic local alignment search tool (BLAST) with the NCBI and UniProt databases. …”
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    基于特征肽的超高效液相色谱-串联质谱法检测矛头蝮蛇蛇毒种属来源及类凝血酶含量
  12. 331652
    “…. • Differently from other targeted agents, our data demonstrate that none of the baseline factors commonly considered in treatment decision process retains a role with venetoclax. Finally, permanent dose reductions and temporary interruptions did not adversely impact PFS suggesting that, if clinically needed, a correct drug management should be adopted with no risk of compromising venetoclax efficacy.…”
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    Coexisting conditions and concomitant medications do not affect venetoclax management and survival in chronic lymphocytic leukemia
  13. 331653
    “…RESULTS: There were 5005 participants included in the final analysis (mean [SD] age, 31.5 [8.3] years; 3587 female participants [71.7%]), including 714 participants in group 1, 717 participants in group 2, 710 participants in group 3, 717 participants in group 4, 708 participants in group 5, 729 participants in group 6, and 710 participants in group 7. …”
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    Effect of Front-of-Package Information, Fruit Imagery, and High–Added Sugar Warning Labels on Parent Beverage Choices for Children: A Randomized Clinical Trial
  14. 331654
    “…Copy number alterations were identified for 24 candidate genes and a final composite score developed from 11 genes. This risk score was able to predict survival in castrate resistant patients after adjusting for known clinical biomarkers. …”
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    Plasma Copy Number Alteration-Based Prognostic and Predictive Multi-Gene Risk Score in Metastatic Castration-Resistant Prostate Cancer
  15. 331655
    “…Additionally, MVs that express tissue factor and leukocyte-platelet interaction antigens were particularly high among non-survivors, suggesting that these MVs may serve as markers of the risk of death. Finally, these findings suggest the participation of innate immunity and tissue factor pathways in the prognosis of COVID-19, and point towards a possible role of MVs as biomarkers of disease prognosis.…”
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    EXTRACELLULAR VESICLES AS MARKERS OF INFLAMMATION AND HYPERCOAGULABILITY DURING THE FIRST MONTH OF SARS-COV-2 INFECTION IN OUTPATIENTS AND HOSPITALIZED PATIENTS
  16. 331656
    “…Out of the total cohort, N=20 (54%), N=7 (19%), N=5 (14%), and N=4 (11%) participants worked full time, part-time, were unemployed, or had not yet finalized their education, respectively. 20 (54%) participants lived as singles, 8 (22%) lived in a partnership, 6 (16%) were married, and 3 (8%) had been divorced. …”
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    Patient-reported long-term outcome following allogeneic hematopoietic stem cell transplantation in pediatric chronic myeloid leukemia
  17. 331657
    “…RESULTS: A total of 6 studies, which comprised a total of 464 participants were included in the final meta-analysis. Compared with conservative treatment, surgical treatment was more effective in lowering Neck-VAS (<3 m: MD = −29.44, 95% CI = (–41.62,–17.27), P < .00001; 3–6 M: MD = −20.97, 95% CI = (–26.36,–15.57), P < .00001; 6 M: MD = −13.40, 95% CI = (–19.39, −7.41), P<.0001; 12 M: MD=−15.53, 95% CI=(-28.38, −2.68), P=.02), Arm-VAS(<3 m: MD = −33.52, 95% CI = (–39.89, −27.16), P < .00001; 3-6 M: MD = −20.97, 95% CI = (–26.36, −15.57), P < .00001; 6 M: MD = −17.52, 95% CI=(–23.94, −11.11), P < .0001; 12 M: MD = −21.91, 95% CI=(–27.09, −16.72), P < .00001) and NDI (<3 m: MD = −8.89, 95% CI = (–11.17, −6.61), P < .00001; 6 M: MD = −5.14, 95% CI = (–7.60, −2.69), P < .0001). …”
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    Management of Cervical Spondylotic Radiculopathy: A Systematic review
  18. 331658
    “…Between 14 February and 7 September 2021, 1,154 PLWH (median age 53 [IQR 44–60] years, 85.5% male) and 440 controls (median age 43 [IQR 33–53] years, 28.6% male) were included in the final analysis. Of the PLWH, 884 received BNT162b2, 100 received mRNA-1273, 150 received ChAdOx1-S, and 20 received Ad26.COV2.S. …”
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    Immunogenicity and reactogenicity of SARS-CoV-2 vaccines in people living with HIV in the Netherlands: A nationwide prospective cohort study
  19. 331659
    “…The type of digital devices used was also associated with myopia and high myopia in Tibet (OR: 1.33, 95% CI: 1.06–1.68 and OR: 1.49, 95% CI: 0.84–2.58, respectively). Finally, examination frequency was found to correlate with high myopia in the Tibet group (OR: 1.79, 95% CI: 0.66–2.71). …”
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    Myopia progression and associated factors of refractive status in children and adolescents in Tibet and Chongqing during the COVID-19 pandemic
  20. 331660
    “…Variants in SH2B1 or a 220–kilobase pair distal deletion of chromosome 16p11.2, including SH2B1, are associated with hyperphagia (pathologic insatiable hunger), severe early-onset obesity, reduced final height, and insulin resistance. Setmelanotide, an MC4R agonist, produced significant weight and hunger reduction after 3 months in patients with SH2B1 heterozygous variants or 16p11.2 deletion in a Phase 2 study. …”
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    RF24 | PSUN91 Body Mass Index and Weight Reduction in Patients With SH2B1 Genetic Variant Obesity After One Year of Setmelanotide
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