“…No significant group by time interactions were found with respect to volumes or memory, although a trend-like group by time interaction on right fornix volume was found (F1,64=5.6, p-uncorrected=.02). Finally, brain-behaviour relationships were explored, restricting our anatomical measure of interest to mean qT1 values within bilateral WM. …”
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“…To identify three homogeneous and meaningful cognitive groups regardless of categorical diagnoses (schizophrenia patients, first-degree relatives and healthy controls), cognitive clustering was performed using a k-means clustering analysis approach, and differences in the BACS subscales (verbal memory, digit sequencing, token motor, verbal fluency, symbol coding and Tower of London) among the cognitive cluster groups were investigated. Finally, the effects of diagnosis and cognition on brain volumes were examined. …”
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“…Interestingly, long-term memory deficits contributed more in differentiating psychotic symptoms from other psychopathological entities (ROD vs CHR/ROP comparison) than along the spectrum of attenuated psychotic symptoms, resulting in full clinical picture of psychosis (CHR vs ROP). Finally, salience attribution difficulties were confirmed to be associated with (sub-)threshold psychotic symptoms, more than to general psychopathology.…”
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“…In addition, these results further reinforce previous evidence suggesting the role of D2R blockade as a mechanism behind increased CBF induced by antipsychotics. Finally, CBF is ultimately a functional marker and this work is important in bridging the considerable gap between the pharmacokinetic and pharmacodynamic effects of compounds with unclear brain functional effects like antipsychotics.…”
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“…The warping optimization implements an iterative refinement, where an input image is repeatedly processed through an optimizer in smaller and smaller patches, incorporating convergence criteria at each patch level to better resolve artifacts, with a final patch size of 3x 5x 3 mm. To assess whole brain voxel-wise group differences and changes over time in scalar indices used AFNI’s 3dttest++ (age, sex, and RMSrel as covariates) with clustsim, a bootstrapping method used to correct for multiple comparisons. …”
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“…In addition, heightened security concerns slowed recruitment in the final months of the study. CONCLUSIONS: We found that advising caregivers to return only if children worsened or remained ill on day 3 resulted in similar rates of caregiver-reported fever and other clinical outcomes on day 8, compared to advising all caregivers to return on day 3. …”
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“…We assessed the ability of Rothman Index scores to determine which patients experienced adverse events. Finally, Rothman Index thresholds were assessed for an association with increased incidence of postdischarge adverse outcomes. …”
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“…RESULTS: A total of 15,729 articles were screened. The final analysis included 23 articles (199,421 subjects). …”
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“…Moreover, changes in all outcomes considered proved time-dependent during the FF/V treatment only, particularly over the second semester. Finally, the overtime adherence to treatment was higher by 22 days during FF/V . …”
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“…For each state, we calculated the ratio of the observed SDR to the rate expected in geographies globally with similar GBD Socio-demographic Index in 2016 (ie, the observed-to-expected ratio); and assessed the age distribution of suicide deaths, and the men-to-women ratio of SDR over time. Finally, we assessed the probability for India and the states of reaching the Sustainable Development Goal (SDG) target of a one-third reduction in SDR from 2015 to 2030, using location-wise trends of the age-standardised SDR from 1990 to 2016. …”
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“…A total of 127,481 were excluded after we applied the exclusion criteria regarding arthroplasty and 17,137 as a result of a history of DCM/HF, recorded in the French national health insurance reimbursement databases, between January 1, 2006, and the date of inclusion. The final cohort included 255,350 individuals (43% men; mean age 72 ± 9 years). …”
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“…Furthermore, given the persistent and often progressive nature of the disease, adenomyosis should also be considered as a potential uterine cause of recurrent miscarriage. Finally, we hope our study highlights the need for high-quality prospective RCT to be undertaken to provide superior evidence for the potential benefit of GnRH agonist pre-treatment. …”
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“…AIM: To investigate whether the use of Fielder XT guidewire increases the final procedural success of CTO-PCI via the anterograde approach. …”
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“…The statistical analyses indicated significant a main effect of “Fatigue” for peak negative ankle power in sagittal plane (p<0.01; d = 1.25). Finally, we could not detect any significant footwear by fatigue interaction effects for all measures of joint kinetics and kinematics. …”
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“…Todos los índices mejoraron significativamente y continuaron mejorando al final del estudio. La evaluación terapéutica en D180 mostró que más del 75% de los pacientes se encontraban satisfechos con la reducción del dolor, la mejora de la movilidad, y la reducción de analgésicos y AINE. …”
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“…The effects of i.t. treatments with glial and NFκB (PDTC) inhibitors on spinal glial activation, TNF-α, IL-1β, CX(3)CR1 and CX(3)CL1 mRNA expression, and NFκB activation were also evaluated. Finally, the contribution of TNF-α and IL-1β to CX(3)CL1 mRNA expression was investigated. …”
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“…Recruitment started January 2007 and ended August 2010, and treatments were finalized in August 2011 with follow-up through March 2013. …”
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“…We also assessed IF by MRI in a subset of the validation cohort which included individuals with and without T2D. Finally, we evaluated the capacity of METS-VAT to detect increased IF defined as Visceral Fat Area (VFA) >100 cm(2) by MRI. …”
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“…Hair cortisol was higher in women than men over the 3 months before training (median (IQR) 7.71 (3.85, 16.0) pg/mg vs 3.53 (2.95, 5.89) pg/mg, p<0.0001) and remained higher in women in the final 3 months of training (8.18 (3.61, 10.37) vs 3.38 (2.38, 5.79) pg/mg, p=0.001). …”
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“…A large number of transcription factors such as WRKY21, WRKY22, NAC1, AP2, EREB1, P450, and CYP81 that both regulate gibberellin signaling and low-temperature signals have also been found. Finally, the molecular mechanism of GA floral induction pathway in the LA hybrid lily ‘Aladdin’ was constructed.…”
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