“…Additionally, this probe can be used to determine that lysosomal stress signaling via TFEB is uncoupled from gross changes in lysosomal pH. Finally, we demonstrated that while overexpression of ARL8B GTPase causes striking alkalinization of peripheral lysosomes in HEK293 T cells, peripheral lysosomes per se are no less acidic than juxtanuclear lysosomes in our cell lines. …”
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“…It has been established that in the placenta, PCs disrupt endocannabinoid homeostasis via impairment of the synthetic and degrading enzymes, leading to a net increase of endocannabinoid levels. Finally, previous studies have shown that THC alters methylation and histone modifications in sperm, brain and blood cells. …”
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“…We used an all-or-none approach for inclusion, compiling results only when a reader completed all reads in a subset. After the final read, we conducted a “surrogate truth” reading, presenting all data to each reader. …”
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“…RESULT: After reviewing 640 articles, 49 studies met the inclusion criteria and were included in the final analysis. The predictors of mortality were; being male (HR = 1.25,95%CI;1.08,1.41,I(2);30.5%), older age (HR = 2.13, 95%CI;1.64,2.62,I(2);59.0%,RR = 1.40,95%CI; 1.26, 1.53, I(2); 48.4%) including a 1 year increase in age (HR = 1.01, 95%CI;1.00,1.03,I(2);73.0%), undernutrition (HR = 1.62,95%CI;1.28,1.97,I(2);87.2%, RR = 3.13, 95% CI; 2.17,4.09, I(2);0.0%), presence of any type of co-morbidity (HR = 1.92,95%CI;1.50–2.33,I(2);61.4%, RR = 1.61, 95%CI;1.29, 1.93,I(2);0.0%), having diabetes (HR = 1.74, 95%CI; 1.24,2.24, I(2);37.3%, RR = 1.60, 95%CI;1.13,2.07, I(2);0.0%), HIV co-infection (HR = 2.15, 95%CI;1.69,2.61, I(2); 48.2%, RR = 1.49, 95%CI;1.27,1.72, I(2);19.5%), TB history (HR = 1.30,95%CI;1.06,1.54, I(2);64.6%), previous second-line anti-TB treatment (HR = 2.52, 95% CI;2.15,2.88, I(2);0.0%), being smear positive at the baseline (HR = 1.45, 95%CI;1.14,1.76, I(2);49.2%, RR = 1.58,95%CI;1.46,1.69, I(2);48.7%), having XDR-TB (HR = 2.01, 95%CI;1.50,2.52, I(2);60.8%, RR = 2.44, 95%CI;2.16,2.73,I(2);46.1%), and any type of clinical complication (HR = 2.98, 95%CI; 2.32, 3.64, I(2); 69.9%). …”
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“…The hepatic expression of two lect2 paralogues was negatively correlated with viscerosomatic index, while htra1b correlated negatively with salmon weight gain and condition factor. Finally, p43 and eif2a were positively correlated with liver Σω3, while these transcripts and eif4b2 showed negative correlations with 18:2ω6 in the liver. …”
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“…Malgré « les protocoles changeant », « le manque de matériel », « le bouleversement des habitudes et repères » mais grâce au « soutien entre équipes » « à la période riche avec les patients et entre soignants » le bilan global s’avère contrasté avec une QV finalement pas plus altérée professionnellement que personnellement. …”
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“…There were 45 (19.1%) patients who died during de follow-up, ELE values were significantly higher on admission. Finally, if we analyze the events in the 48 HRTpatients (21%) compared to the non-TAR 187 patients (79%), they had significantly more hemorrhagic events, and death from all causes, p <0.05, events was resume in Table 2. …”
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“…In external validation, a final model including these variables showed excellent discrimination (C statistic, 0.95; 95% CI, 0.95-0.96), with sensitivity of 21.2%, specificity of 99.9%, positive predictive value of 38.1%, and negative predictive value of 99.7% at a predicted risk threshold of 10% or greater. …”
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“…Results: A total of 96 participants (77 F, 17 M) submitted the questionnaire, of which 94 were included in the final data analysis. Ages ranged between 24 and 79 years (mean 50.1 ± 12.1 years). …”
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“…Outcomes were analyzed using generalized linear modeling with backward stepwise selection for final model building. RESULTS: A total of 107 patients (median age, 14.7 years [interquartile range, 12.8-16.9 years]; 63 male participants [58.9%]) completed the clinical trial; 54 patients received standard care, and 53 patients also received the VR intervention. …”
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“…Patients treated with Huisheng Oral liquid for ≥3 months also showed an improvement in the 2-year survival rate, and the 2-year survival rate tended to increase as the treatment duration increased. Finally, male and FIB ≥ 4 g/L were risk factors for prognosis.…”
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“…These models also highlight the independent risk for severe disease associated with obesity and should further emphasize that even in the absence of other comorbidities, vaccination is particularly important for these women. Finally, the model also provides useful information for policy makers when prioritizing national vaccination programs to quickly protect those at the highest risk of critical and fatal COVID-19.…”
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“…Then, the difference in the prevalence of hypertension between baseline characteristics was estimated by the t- and χ(2)-test. Finally, multivariable-adjusted logistic regression models were used to explore the associations of famine exposure and obesity parameters with odds of prevalence of hypertension. …”
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“…Para as análises foram coletadas amostras de sangue periférico, sendo a amostra inicial descrita como D+0 e a final como D+90. A análise sorológica foi realizada por meio do kit comercial, de imunoensaio fluorescente (IchromaTM COVID-19 Ab) e os procedimentos foram realizados de acordo com as recomendações do fabricante. …”
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“…OBJETIVOS: Desde sua ascensão no final de 2019, o SARS-CoV-2 infectou mais de 200 milhões de pessoas e causou mais de 4 milhões de mortes no mundo. …”
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“…Despite the elevation of dietary Se to 0.79 mg kg(−1) not affecting basal cortisol levels, 2 h post-stress plasma cortisol levels were markedly increased. Finally, at 24 h post-stimulation, dietary OH-SeMet supplementation significantly increased the expression of the antiviral response myxovirus protein gene, showing, for the first time in gilthead seabream, the importance of dietary Se levels on antiviral defense.…”
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“…Furthermore, some ncRNAs have emerged as potential therapeutic targets, some of which include lncRNAs NEAT1, NEAT2 and lnr6RNA, 152742 in tuberculosis; MALAT1, HEAL, SAF, lincRNA-p21, NEAT1, GAS5, NRON, LINC00173 in HIV/AIDS; miRNA-146a in malaria. Finally, miR-135 and miR-126 were proposed as potential targets for the development of therapeutic vaccine against leishmaniasis. …”
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“…To quantify the increase of PrPc and to detect the subcellular compartmentalization of PrPc within PDAC cells, immuno-gold stoichiometry within specific cell compartments was analyzed with electron microscopy. Finally, an analysis of quantitative PrPc expression according to prognostic data, such as cancer stage, recurrence of the disease at 12 mo after surgery and recurrence during adjuvant chemotherapy was made. …”
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“…Results showed that (1) the final body weight, average daily gain, and average feed intake of G18 was significantly higher (p < 0.05) than CG; in contrast, the feed conversion ratio of G18 was significantly lower than CG and G12 (p < 0.05); the feed cost per head per day of CG was significantly higher (p < 0.05) than that of G18 and G24, and exhibited obvious linearly decrease (p = 0.04) with increasing GBLR supplementation; and apparent total-tract digestibility of DM and NDF in GBLR treatments were significantly higher (p < 0.05) than CG; (2) alanine transaminase (ALT) concentration in the G18 group was significantly lower (p < 0.05) than those in the control group; aspartate transaminase (AST) concentration in the G24 was significantly lower (p < 0.05) than those in the control group, and an increase in dietary level of GBLR tended to result in a linear decrease (p = 0.09) in the concentration of serum AST; (3) the concentration of malondialdehyde (MDA) demonstrated a tendency to decrease (p = 0.06) linearly with increasing GBLR supplementation; however, glutathione peroxidase (GSH-PX) activity in G12 was significantly higher (p < 0.05) than CG, G6, and G24; in addition, superoxide dismutase (SOD) activity in G18 was significantly higher (p < 0.05) than CG and G6; concentration of immunoglobulin M (IgM), immunoglobulin G (IgG), and immunoglobulin A (IgA) were not affected by GBLR, but increasing dietary GBLR showed a tendency (p = 0.08) to linearly increase the IgG concentration; the content of interleukin 4 (IL4) was significantly higher (p < 0.05) in G12, G18, and G24 than that in CG and G6; (4) There were similar NH(3)-N, pH, TVFA, and butyrate for goats fed different levels of GBLR supplementation; the C2 (p = 0.07) and acetate: propionate (p = 0.06) demonstrated a tendency to increase linearly with increasing level of GBLR supplementation, separately; however, it was observed that concentration of propionate showed a tendency to decrease (p = 0.08) linearly in response to GBLR supplementation; and (5) Increasing dietary GBLR tended to linearly enhance the lightness (L*) (p = 0.07) and yellowness (b*) (p = 0.09) values of longissimus dorsi muscles; the redness (a*) value in G18 was significantly higher than that in CG (p < 0.05).…”
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“…However, due to the small sample size of our collective, larger studies are needed to allow for a final evaluation on the significance of PSMA-targeted diagnostic and therapy for ATC and PDTC.…”
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