“…At enrolment, in the metformin and placebo arms, mean fasting glucose was 6.37 mmol/l (95% CI 6.23, 6.50) and 6.26 mmol/l (95% CI 6.15, 6.36), respectively, and mean 2 h glucose levels following a 75 g oral glucose load were 8.39 mmol/l (95% CI 8.22, 8.56) and 8.24 mmol/l (95% CI 8.07, 8.41), respectively. At the final assessment at 12 months, 145/182 (79.7%) individuals randomised to metformin compared with 158/182 (86.8%) randomised to placebo indicated that they had taken >95% of their medicines in the previous 28 days (p=0.068). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Whether a bone marrow biopsy in the work-up of unexplained systemic inflammation would have obtained an earlier diagnosis with the finding of vacuoles (noting that these are not universally present in patients with VEXAS) is also uncertain. Finally, the lack of macrocytosis is unexplained and atypical for VEXAS. …”
Enlace del recurso
Enlace del recurso

“…The Control arm starts with CHHS alone for 3 months, then VINT + CHHS for 3 months, and finally CHHS alone for 3 months. Both groups are assessed at baseline (0), 3, 6 and 9 months. …”
Enlace del recurso
Enlace del recurso

“…Sixteen studies were finally included. Results from pairwise meta-analyses are shown in Figure 1, results from network meta-analyses in Figure 2 and 3. …”
Enlace del recurso
Enlace del recurso

“…We then used propensity score matching between the three drug classes to assemble a sample in which each patient receiving an SGLT-2i was matched to one on a GLP-1ra, and each patient on a DPP-4i was matched to one on a GLP-1ra, adjusting for covariates. We finally used GLP-1ras as references in the logistic regression. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Based on this, we constructed a protein‒protein interaction network, performed gene ontology and KEGG enrichment analyses, and conducted pathway network analysis to elucidate the correlation between the active ingredients in ZLJT and signaling pathways. Finally, molecular docking was performed using AutoDockVina, PYMOL 2.2.0, and Discovery Studio Client v19.1.0 software to simulate spatial and energy matching during the recognition process between predicted targets and their corresponding compounds. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Multivariable logistic regression with stepwise selection yielded a final model controlling for employment, past COVID-19, and blood disorders using SAS v9.4. …”
Enlace del recurso
Enlace del recurso

“…A panel of international experts on IE assigned a final diagnosis, which served as the reference standard. …”
Enlace del recurso
Enlace del recurso

“…Fourth, we recruited students from Nantong University in China to participate in an online questionnaire survey. Finally, based on the data collected, we conducted quantitative and qualitative analyses to relate the independent variables to the dependent variable. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…With 1/10 of a cubic centimeter of adrenalin per kilo (eight experiments) the averages were: a maximum dilatation of 3.87 millimeters, a beginning recovery in ten minutes, with complete recovery of the pupil in forty-five minutes. Finally, eleven experiments with 2/10 of a cubic centimeter of adrenalin per kilo gave averages as follows: a maximum dilatation of 4.38 millimeters, a beginning recovery from dilatation in twenty minutes, with complete recovery only after one hundred minutes or more. …”
Enlace del recurso
Enlace del recurso

“…For as the bacteria diminish and the sensitizer increases, a changed proportion between them is established which, finally, as experiment has shown, results in a failure of anaphylatoxin production. …”
Enlace del recurso
Enlace del recurso

“…Tadpoles fed on thyroid with practically no iodine grow better than the controls, in this instance the thyroid acting simply as a food. Finally, the interest that the results of these experiments may have in connection with the question of function in tumor tissue should be pointed out. …”
Enlace del recurso
Enlace del recurso

“…The therapeutic experiments with Tr. equinum, Tr. equiperdum, and Tr. evansi are too few to admit of final conclusions, but apparently from the evidence at hand, much the same curative range is operative in Tr. evansi infections, while larger doses or a different system of treatment should have been employed in the treatment of rabbits infected with our strains of Tr. equinum and Tr. equiperdum. …”
Enlace del recurso
Enlace del recurso

“…There is already at hand considerable evidence which will be assembled in a later paper favoring the single group, C(6)H(10)O(5), as the molecule. Finally, problems in polarized light may receive more satisfactory explanations through a clearer notion of the molecular structure of the carbohydrates.…”
Enlace del recurso
Enlace del recurso

“…They serve also to reemphasize the fact, apparent from several studies but perhaps not sufficiently realized, that the R variants of the pneumococcus, even though obtained under the same conditions from the same type but from different strains, may vary definitely in their various attributes. Finally, they strongly suggest that the degree of virulence of a given strain of a bacterial species may be determined not only by its ability to multiply in the environment of the host and to synthesize certain substances of definite chemical and antigenic properties, but also by the capacity to elaborate these in greater or lesser degree and under the conditions of parasitism within the animal body to maintain them in contact with the soma of the cell in such state that they afford an efficient barrier to the defensive mechanisms of the host.…”
Enlace del recurso
Enlace del recurso

“…The need of the hour is to explore in greater detail the need and justification for covert treatment, to lay out clear and firm parameters for its legitimate use, follow it up with standard literature and, finally, to establish clinical practice guidelines by unconflicted authors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: We discuss the changes that have occurred in the patterns of use and procurement of these products with exile and sedentarization in refugee camps, and conclude that refugees are not simply passive recipients of national and international aid, but rather struggle to maintain and recover their traditional ethnobiological practices in exile. Finally, we suggest further research into the ethnobiological practices and knowledge of displaced populations. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…SPARCS data are based on clinical diagnoses and include information on final diagnosis, providing a means for comparing the chief complaint (from SS) to a diagnosis code (from SPARCS), for evaluating how well the syndrome is captured by SS and for assessing if it would be advantageous to get SS ED diagnosis codes in a more timely and complete manner. …”
Enlace del recurso

“…Furthermore, we investigated the effects of VEGF-A inhibition on receptor activation and production of other cytokines. Finally, the effects of VEGF-A inhibition on the proliferation, migration, and invasion in the cell lines were ascertained. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition, to be included studies must have reported scores for change from baseline, or baseline and final International Index of Erectile Functioning-Erectile Functioning domain score (IIEF-EF), and be published in either English, French, Dutch, or German. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso