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  1. 332221
    por Smith, Theobald
    Publicado 1909
    “…They are apparently more efficacious at the end of forty-eight hours than immediately after preparation. The experiments finally prove that a relatively high degree of active immunity can be induced by a harmless procedure, whereas the use of toxin alone leading to very severe local lesions is incapable of producing more than an insignificant protection. …”
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    ACTIVE IMMUNITY PRODUCED BY SO CALLED BALANCED OR NEUTRAL MIXTURES OF DIPHTHERIA TOXIN AND ANTITOXIN
  2. 332222
    por Couret, Maurice, Walker, James
    Publicado 1913
    “…It has long been known that tissue kept for several days in a perfectly aseptic condition and at body heat, or preferably at slightly higher temperature undergoes softening and final disintegration of its cells. Wells and others who have made a thorough study of this phenomenon find that different enzymic actions take place in this process: thus in the liver they find that soluble nitrogen compounds are greatly increased, the nucleoproteids are altered by nuclease, the purin bases are freed and in their turn acted upon by the guanase and adenase, the fats are split and fatty acids set free, the glycogen gives rise to glucose and undergoes further splitting. lecithin is cleaved, and allied bodies appear, and there is a marked appearance of cholin and cholesterin. …”
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    THE CULTIVATION OF AMŒBÆ IN PURE CULTURE UPON AUTOLYZED TISSUES
  3. 332223
    por Graybill, H. W., Smith, Theobald
    Publicado 1920
    “…Three controls received nothing; one showed blackhead lesions at the autopsy. In a final experiment three turkeys were fed cultures of feces from the ceca of diseased turkeys, three were fed cultures of feces of old turkeys from an infected flock, and three controls were fed nothing. …”
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    PRODUCTION OF FATAL BLACKHEAD IN TURKEYS BY FEEDING EMBRYONATED EGGS OF HETERAKIS PAPILLOSA
  4. 332224
    “…Countries agree that randomised controlled head-to-head trials (head-to-head RCT) with a high degree of internal and external validity provide the most reliable and least biased evidence of a drug's relative treatment effects (as do systematic reviews and meta-analyses of these RCT). Final outcome parameters reflecting long-term treatment objectives (mortality, morbidity, quality of life) are preferred to surrogate parameters. …”
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    Methods for the comparative evaluation of pharmaceuticals
  5. 332225
    por Segré, C
    Publicado 2010
    “…The conference spread over two and a half days (Wednesday 19th to Friday 21st May) and touched on a broad spectrum of topics: from basic biology to development, from cancer therapies to modelling and top-down new generation global approaches. The final selection of presentations has been a tough task for us organisers (Chiara Segré, Federica Castellucci, Francesca Milanesi, Gianluca Varetti and Gian Maria Sarra Ferraris), due to the high scientific level of the abstracts submitted. …”
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    Something going on in Milan: a review of the 4th International PhD Student Cancer Conference
  6. 332226
    por Sissoko, Daouda, Laouenan, Cedric, Folkesson, Elin, M’Lebing, Abdoul-Bing, Beavogui, Abdoul-Habib, Baize, Sylvain, Camara, Alseny-Modet, Maes, Piet, Shepherd, Susan, Danel, Christine, Carazo, Sara, Conde, Mamoudou N., Gala, Jean-Luc, Colin, Géraldine, Savini, Hélène, Bore, Joseph Akoi, Le Marcis, Frederic, Koundouno, Fara Raymond, Petitjean, Frédéric, Lamah, Marie-Claire, Diederich, Sandra, Tounkara, Alexis, Poelart, Geertrui, Berbain, Emmanuel, Dindart, Jean-Michel, Duraffour, Sophie, Lefevre, Annabelle, Leno, Tamba, Peyrouset, Olivier, Irenge, Léonid, Bangoura, N’Famara, Palich, Romain, Hinzmann, Julia, Kraus, Annette, Barry, Thierno Sadou, Berette, Sakoba, Bongono, André, Camara, Mohamed Seto, Chanfreau Munoz, Valérie, Doumbouya, Lanciné, Souley Harouna, Kighoma, Patient Mumbere, Koundouno, Fara Roger, Réné Lolamou, Loua, Cécé Moriba, Massala, Vincent, Moumouni, Kinda, Provost, Célia, Samake, Nenefing, Sekou, Conde, Soumah, Abdoulaye, Arnould, Isabelle, Komano, Michel Saa, Gustin, Lina, Berutto, Carlotta, Camara, Diarra, Camara, Fodé Saydou, Colpaert, Joliene, Delamou, Léontine, Jansson, Lena, Kourouma, Etienne, Loua, Maurice, Malme, Kristian, Manfrin, Emma, Maomou, André, Milinouno, Adele, Ombelet, Sien, Sidiboun, Aboubacar Youla, Verreckt, Isabelle, Yombouno, Pauline, Bocquin, Anne, Carbonnelle, Caroline, Carmoi, Thierry, Frange, Pierre, Mely, Stéphane, Nguyen, Vinh-Kim, Pannetier, Delphine, Taburet, Anne-Marie, Treluyer, Jean-Marc, Kolie, Jacques, Moh, Raoul, Gonzalez, Minerva Cervantes, Kuisma, Eeva, Liedigk, Britta, Ngabo, Didier, Rudolf, Martin, Thom, Ruth, Kerber, Romy, Gabriel, Martin, Di Caro, Antonino, Wölfel, Roman, Badir, Jamal, Bentahir, Mostafa, Deccache, Yann, Dumont, Catherine, Durant, Jean-François, El Bakkouri, Karim, Gasasira Uwamahoro, Marie, Smits, Benjamin, Toufik, Nora, Van Cauwenberghe, Stéphane, Ezzedine, Khaled, Dortenzio, Eric, Pizarro, Louis, Etienne, Aurélie, Guedj, Jérémie, Fizet, Alexandra, Barte de Sainte Fare, Eric, Murgue, Bernadette, Tran-Minh, Tuan, Rapp, Christophe, Piguet, Pascal, Poncin, Marc, Draguez, Bertrand, Allaford Duverger, Thierry, Barbe, Solenne, Baret, Guillaume, Defourny, Isabelle, Carroll, Miles, Raoul, Hervé, Augier, Augustin, Eholie, Serge P., Yazdanpanah, Yazdan, Levy-Marchal, Claire, Antierrens, Annick, Van Herp, Michel, Günther, Stephan, de Lamballerie, Xavier, Keïta, Sakoba, Mentre, France, Anglaret, Xavier, Malvy, Denis
    Publicado 2016
    “…A “target value” of mortality was defined a priori for each stratum, to guide the interpretation of interim and final analysis. Between 17 December 2014 and 8 April 2015, 126 patients were included, of whom 111 were analyzed (adults and adolescents, ≥13 y, n = 99; young children, ≤6 y, n = 12). …”
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    Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea
  7. 332227
    “…RESULTS: A total of 263 residents were finally included in the analysis. Among these high-altitude residents, CMS symptom scores decreased for oxygen inhalation methods B, C, and D at 15 and 30 days after oxygen intake and 15 days after termination, including dyspnea, palpitation, and headache index, compared to those before oxygen intake (B group: Z = 5.604, 5.092, 5.741; C group: Z = 4.155, 4.068, 4.809; D group: Z = 6.021, 6.196, 5.331, at the 3 time points respectively; all P < 0.05/3 vs. before intake). …”
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    Intermittent Oxygen Inhalation with Proper Frequency Improves Overall Health Conditions and Alleviates Symptoms in a Population at High Risk of Chronic Mountain Sickness with Severe Symptoms
  8. 332228
    “…Weekly body weight did not differ in male offspring, but an increase in body weight from Week 13 onwards was observed in Old-ET females (final body weight at post-natal Week 30: 38.5 ± 0.8 versus 33.4 ± 0.8 g, P < 0.05). …”
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    Advanced maternal age causes adverse programming of mouse blastocysts leading to altered growth and impaired cardiometabolic health in post-natal life
  9. 332229
    “…(4) What is the functional outcome as assessed by Musculoskeletal Tumor Society (MSTS) score at final followup? METHODS: We performed a retrospective chart review of every patient in whom a LUMiC(®) prosthesis was used to reconstruct a periacetabular defect after internal hemipelvectomy for a pelvic tumor from July 2008 to June 2014 in eight centers of orthopaedic oncology with a minimum followup of 24 months. …”
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    LUMiC(®) Endoprosthetic Reconstruction After Periacetabular Tumor Resection: Short-term Results
  10. 332230
    “…Estrogen status: Low HDL was seen in three out of seven patients, low albumin in four out of 10 and obese BMI in nine out of 11. Finally, 11 out of 12 patients had at least one indicator of high estrogen. …”
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    Male Breast Cancer and Hyperestrogenemia: A Thirteen-Year Review
  11. 332231
    “…Two new potential drug resistance-associated mutations in EGFR and KRAS have been found and are worthy of further study. Finally, our research shows that the evolutionary process of tumor cloning can be artificially regulated and intervened, possibly providing a new way to treat tumors.…”
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    Competitive evolution of NSCLC tumor clones and the drug resistance mechanism of first-generation EGFR-TKIs in Chinese NSCLC patients
  12. 332232
    “…However, this did not reach statistical significance when we compared embryos with a number of variants lower or higher than two (39.15 versus 20.0, P = 0.188). Finally, a clear positive association between the mtDNA variants and copy number was reported when we compare embryos with or without heteroplasmy (0.0013 ± 0.0009 versus 0.0025 ± 0.0014, P < 0.001) and among different numbers of variants (0:0.0013 ± 0.0009, 1–2:0.0023 ± 0.0012, >2:0.0043 ± 0.0014, P < 0.05). …”
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    Comprehensive mitochondrial DNA analysis and IVF outcome
  13. 332233
    “…Companions provided practical support, including encouraging women to move around, providing massage, and holding her hand. Finally, companions gave emotional support, using praise and reassurance to help women feel in control and confident, and providing a continuous physical presence. …”
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    Perceptions and experiences of labour companionship: a qualitative evidence synthesis
  14. 332234
    por Khalid, Salema, Smith, Richard, Cole, Zoe
    Publicado 2019
    “…Further research and deeper understanding is needed of the pathways that lead to a flare of GCA while on optimal treatment. Finally, this case underscores the dire need for advances in the development of clinically useful biomarkers to help monitor disease activity and predict relapses in patients on TCZ. …”
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    20. Tocilizumab: is out of sight really out of mind?
  15. 332235
    por Soobraty, Noora, Green, Michael
    Publicado 2019
    “…On review of her previous CT imaging, it was noted that the aortic wall was thickened which prompted further investigations in the form of a PET CT and IgG subclasses that led to the final diagnosis of large vessel vasculitis (LVV) and IgG4-related disease. …”
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    53. An uncommon cause of pyrexia of unknown origin
  16. 332236
    “…Collectively, we conclude that decreased OATP1B1 expression and function in variant genotypes influence altered transport for PVA. Finally, the functional consequences of 3αPVA formation on PVA transport was confirmed in our study. …”
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    3012 Functional consequences of pravastatin isomerization on OATP1B1-mediated transport
  17. 332237
    “…Decreased odds of linkage failure were also found among patients belonging to the baby boomer population (aOR, 0.64; 95% CI, 0.46-0.91) and individuals with HBV co-infection (aOR, 0.36; 95% CI, 0.14-0.94). Finally, odds of linkage failure were increased among patients without health insurance (aOR, 1.952; 95% CI, 1.01-3.79) and with public health insurance (aOR, 2.140; 95% CI, 1.08-4.24). …”
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    3435 Predicting Linkage-to-Care Outcomes Among Patients Screened for Hepatitis C in an Urban Academic Emergency Department
  18. 332238
    “…Mothers seem preferential to social worker-led interventions compared with pediatrician-led, but most mothers were indifferent. Finally, mothers expressed low support from the Latino community in Baltimore. …”
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    2329: Psychosocial risk factors mental health symptoms, and intervention preferences of Latino immigrant parents presenting to a pediatric clinic
  19. 332239
    “…Primary immunogenicity endpoints were analysed in infants in either phase who received all planned injections, had blood samples analysed at the relevant timepoints, and presented no major protocol violations considered to have an effect on the immunogenicity results of the study, and included serum anti-P2-VP8 IgA, IgG, and neutralising antibody geometric mean titres and responses measured 4 weeks after the final injection in vaccine compared with placebo groups. …”
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    Safety and immunogenicity of a parenteral trivalent P2-VP8 subunit rotavirus vaccine: a multisite, randomised, double-blind, placebo-controlled trial
  20. 332240
    “…Patients randomly assigned to sarilumab therapy at baseline progressing to Brescia-COVID 2-3 will be rescued according to local clinical practice protocols. A final follow-up visit will be conducted for all patients at day 29 from randomization, regardless of initial treatment assignment. …”
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    Sarilumab versus standard of care for the early treatment of COVID-19 pneumonia in hospitalized patients: SARTRE: a structured summary of a study protocol for a randomised controlled trial
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