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681
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682por Bustamante, Danilo E., Mansilla, Andres, Calderon, Martha S., Rosenfeld, Sebastian, Rodriguez, Juan P., Mendez, Fabio, Bahamonde, Francisco, Gerard, Karin, Lopez, Zambra, Ceroni, Constanza, Aros, Veronica, Perez, Carolina“…The generitype Lessonia flavicans Bory is an endemic and important kelp from Sub-Antarctic Magellanic ecoregion that shows affinity to extreme salinity, temperature, and photoperiod conditions. …”
Publicado 2019
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683por Pustelny, Katarzyna, Grygier, Przemyslaw, Barzowska, Agata, Pucelik, Barbara, Matsuda, Alex, Mrowiec, Krzysztof, Slugocka, Emilia, Popowicz, Grzegorz M., Dubin, Grzegorz, Czarna, Anna“…Here, we show that commonly available flavones are effective inhibitors of DYRK1A. The observed biochemical activity of flavone compounds is confirmed by crystal structures solved at 2.06 Å and 2.32 Å resolution, deciphering the way inhibitors bind in the ATP-binding pocket of the kinase, which is driven by the arrangement of hydroxyl moieties. …”
Publicado 2023
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684“…Flavone acetic acid (FAA) is a synthetic flavonoid with dramatic pre-clinical anti-tumour activity involving a vascular component in its mechanism but no clinical effects have been seen to date. …”
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685“…The antitumour activity of flavone acetic acid (FAA) was evaluated against two human colorectal carcinoma (HCC) lines, HCC-P2988 and HCC-M1410, transplanted into nude mice. …”
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686“…This study has indicated that the tumour is resistant to a large number of standard anti-cancer drugs but is highly responsive to the investigational agent flavone acetic acid (FAA). The levels of FAA achieved in tumours are lower than those necessary for activity in vitro suggesting its mechanism of action in vivo is not direct cytotoxicity. …”
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687“…In this study, a simple method for preparative separation of the two flavone glucuronides was established with macroporous resins. …”
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688por Zhou, Jian-Min, Lee, Eunjung, Kanapathy-Sinnaiaha, Francesca, Park, Younghee, Kornblatt, Jack A, Lim, Yoongho, Ibrahim, Ragai K“…O-methyltransferase (TaOMT2) catalyzes the sequential methylation of the flavone, tricetin, to its 3'-methyl- (selgin), 3',5'-dimethyl- (tricin) and 3',4',5'-trimethyl ether derivatives. …”
Publicado 2010
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689por Thomas, Christan M., Wood, Robert C., Wyatt, Jarrett E., Pendleton, Morgan H., Torrenegra, Ruben D., Rodriguez, Oscar E., Harirforoosh, Sam, Ballester, Maria, Lightner, Janet, Krishnan, Koyamangalath, Ramsauer, Victoria P.“…In conclusion, the specific chemical properties of these two flavone isomers dictate mechanistic properties which may be relevant when evaluating biological responses to flavones.…”
Publicado 2012
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690“…The natural flavone acacetin has been demonstrated to inhibit transient outward potassium current (I(to)) in human atrial myocytes. …”
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691“…In this work, we report two new flavone-based fluorescent probes, MC-Mito1 and MC-Mito2, for monitoring mitochondria in living cells. …”
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692por Homayoon, Amin, Hamidi, Mahmood Reza, Haddadi, Azam, Madani, Zahra Sadat, Moudi, Ehsan, Bijani, AliEnlace del recurso
Publicado 2015
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693por LeJeune, Timothy M., Tsui, Hei Yin, Parsons, Laura B., Miller, Gerald E., Whitted, Crystal, Lynch, Kayla E., Ramsauer, Robert E., Patel, Jasmine U., Wyatt, Jarrett E., Street, Doris S., Adams, Carolyn B., McPherson, Brian, Tsui, Hei Man, Evans, Julie A., Livesay, Christopher, Torrenegra, Ruben D., Palau, Victoria E.“…In previous studies we introduced two plant derived isomeric flavonoids, flavone A and flavone B which induce apoptosis in highly tumorigenic cancer cells of the breast, colon, pancreas, and the prostate. …”
Publicado 2015
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694por Han, Y.M., Peteet, D.M., Arimoto, R., Cao, J.J., An, Z.S., Sritrairat, S., Yan, B.Z.Enlace del recurso
Publicado 2016
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698por Jang, Se-Won, Cho, Chi Heung, Jung, Young-Sung, Rha, Chansu, Nam, Tae-Gyu, Kim, Dae-Ok, Lee, Yeong-Geun, Baek, Nam-In, Park, Cheon-Seok, Lee, Byung-Hoo, Lee, So-Young, Shin, Hee Soon, Seo, Dong-Ho“…α-Flavone glycosides have beneficial properties for applications in the pharmaceutical, cosmetic, and food industries. …”
Publicado 2018
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699por Zandi, Keivan, Lani, Rafidah, Wong, Pooi-Fong, Teoh, Boon-Teong, Sam, Sing-Sin, Johari, Jefree, Mustafa, Mohd Rais, AbuBakar, Sazaly“…Flavone (100 μg/mL) did not promote or inhibit Vero cell proliferation. …”
Publicado 2012
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700“…The twigs of Morus alba L. were found to show strong tyrosinase inhibition activity, and the responsible active components in the extract were further investigated in this study. A flavone, named morusone (1), and sixteen known compounds 2–17 were isolated from M. alba twigs and their structures were identified by interpretation of the corresponding ESI-MS and NMR spectral data. …”
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