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881por Ghiƫu, Alexandra, Pavel, Ioana Zinuca, Avram, Stefana, Kis, Brigitta, Minda, Daliana, Dehelean, Cristina Adriana, Buda, Valentina, Folescu, Roxana, Danciu, Corina“…Due to the plethora of biological activities, apigenin (4′,5,7 trihydroxyflavone) is a main representant of the flavone subclass. Although the antiproliferative and antiangiogenic effects of apigenin were studied on a significant number of human and murine melanoma cell lines, in order to complete the data existing in the literature, the aim of this study is to evaluate the in vitro effect of apigenin on SK-MEL-24 human melanoma cell line as well as in vivo on tumor angiogenesis using the aforementioned cell line on the chorioallantoic membrane assay. …”
Publicado 2021
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882por Serino, Elena, Chahardoli, Azam, Badolati, Nadia, Sirignano, Carmina, Jalilian, Fereshteh, Mojarrab, Mahdi, Farhangi, Zahra, Rigano, Daniela, Stornaiuolo, Mariano, Shokoohinia, Yalda, Taglialatela-Scafati, Orazio“…The sesquiterpene hanphyllin (8) showed a selective cholesterol-lowering activity (−12.7% at 30 µM), santoflavone (13) stimulated glucose uptake via the GLUT transporter (+16.2% at 30 µM), while the trimethoxylated flavone salvigenin (14) showed a dual activity in decreasing lipid levels (−22.5% palmitic acid biosynthesis at 30 µM) and stimulating mitochondrial functionality (+15.4% at 30 µM). …”
Publicado 2021
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883por Shikishima, Yasuhiro, Tsutsumi, Rie, Kawakami, Ayuka, Miura, Hiroyuki, Nii, Yoshitaka, Sakaue, Hiroshi“…Sudachitin, a polymethoxylated flavone, has been reported as having favorable effects on lipid and glucose metabolism but results from clinical trials have been inconsistent. …”
Publicado 2021
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884por Carlini, Lavinia, Tancreda, Gabriele, Iobbi, Valeria, Caicci, Federico, Bruno, Silvia, Esposito, Alfonso, Calzia, Daniela, Benini, Stefano, Bisio, Angela, Manni, Lucia, Schito, Anna, Traverso, Carlo Enrico, Ravera, Silvia, Panfoli, IsabellaEnlace del recurso
Publicado 2022
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885
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886“…Flavin-containing monooxygenases (FMOs) catalyse asymmetric oxidation reactions that have potential for preparative organic synthesis, but most use the more expensive, phosphorylated nicotinamide cofactor NADPH to reduce FAD to FADH(2) prior to formation of the (hydro)peroxy intermediate required for substrate oxygenation. …”
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888por Battistoni, Benjamín, Salazar, Juan, Vega, Wladimir, Valderrama-Soto, Diego, Jiménez-Muñoz, Pablo, Sepúlveda-González, Ailynne, Ahumada, Sebastián, Cho, Isaac, Gardana, Claudio Sebastiano, Morales, Héctor, Peña-Neira, Álvaro, Silva, Herman, Maldonado, Jonathan, González, Mauricio, Infante, Rodrigo, Pacheco, Igor“…Japanese plum fruits are rich in phenolic compounds, such as anthocyanins and flavan-3-ols, whose contents vary significantly among cultivars. …”
Publicado 2022
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890por Thatcher, N., Dazzi, H., Mellor, M., Ghosh, A., Carrington, B., Johnson, R. J., Loriaux, E. M., Craig, R. P.“…Recombinant interleukin 2 (rIL-2) and flavone acetic acid (FAA) were used to treat 34 patients with progressing metastatic melanoma. …”
Publicado 1990
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891“…Flavone acetic acid (FAA) is extremely active against subcutaneous transplantable tumours in mice, but disappointingly there has been no demonstrable clinical activity. …”
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892“…Plasma samples were collected from 20 patients undergoing phase I clinical trial with flavone-8-acetic acid (FAA; 4.8 g m-2 per dose) in combination with recombinant human interleukin-2 (rhIL-2; 6-18 i.u. m-2 per day) for the treatment of metastatic melanoma. …”
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893“…Here we show that a naturally occurring flavone of citrus origin, tangeretin (5,6,7,8,4'-pentamethoxyflavone), induces apoptosis in human promyelocytic leukaemia HL-60 cells, whereas the flavone showed no cytotoxicity against human peripheral blood mononuclear cells (PBMCs). …”
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894“…A strategy for analyzing flavone C-glucosides in the leaves of different species of bamboo was developed. …”
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895“…The objective of the study is a comparative evaluation of flavone isolated from Mucuna pruriens and coumarin isolated from Ionidium suffruticosum was assessed for the hypolipidemic activity in rats fed with high fat diet. …”
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896“…This study aimed to determine the effects of Bauhinia championii flavone (BCF) on myocardial ischemia/reperfusion injury (MI/RI) in rats and to explore potential mechanisms. …”
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897por Kim, Yong Ho, Warren, Sarah H., Krantz, Q. Todd, King, Charly, Jaskot, Richard, Preston, William T., George, Barbara J., Hays, Michael D., Landis, Matthew S., Higuchi, Mark, DeMarini, David M., Gilmour, M. IanEnlace del recurso
Publicado 2018
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898por Weng, Jing-Ru, Bai, Li-Yuan, Lin, Wei-Yu, Chiu, Chang-Fang, Chen, Yu-Chang, Chao, Shi-Wei, Feng, Chia-Hsien“…To identify the bioactive constituents from M. bontioides, a newly-identified flavone, 3,4′-dimethoxy-3′,5,7-trihydroxyflavone (compound 1), along with eight known compounds, were investigated in human MCF-7 breast cancer, SCC4 oral cancer, and THP-1 monocytic leukemia cells. …”
Publicado 2017
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899por Benninghoff, Abby D., Bates, Melissa A., Chauhan, Preeti S., Wierenga, Kathryn A., Gilley, Kristen N., Holian, Andrij, Harkema, Jack R., Pestka, James J.Enlace del recurso
Publicado 2019
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900por Alsharairi, Naser A.“…Indeed, the mechanisms by which S. baicalensis and its flavone compounds exert a protective effect against nicotine-induced NSCLC and asthma are not yet fully understood. …”
Publicado 2021
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