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  1. 17461
    “…The A260T mutation is located in the phosphate loop of the flavin adenine dinucleotide (FAD) binding domain of CRY2. …”
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    A Cryptochrome 2 mutation yields advanced sleep phase in humans
  2. 17462
    “…Prostaglandin F2α synthase or old yellow enzyme (OYE), an NAD(P)H flavin oxidoreductase, has been involved in the activation pathway of other trypanocidal drugs such as Nfx; however, its role in the mechanism of action of Bz is uncertain. …”
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    Prostaglandin F2α synthase in Trypanosoma cruzi plays critical roles in oxidative stress and susceptibility to benznidazole
  3. 17463
    “…We established that the production of oxidoreductases, namely, NADH flavin oxidoreductases and NAD(P)+-dependent aldehyde dehydrogenases, as well as transferases was enhanced at all stages of the TNT transformation by Y. lipolytica. …”
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    Proteomic Analysis of 2,4,6-Trinitrotoluene Degrading Yeast Yarrowia lipolytica
  4. 17464
    “…Herein, we show that auxin produced by the flavin monooxygenases YUC2 and YUC6 in the sporophytic microsporocytes is essential for early stages of pollen development. …”
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    Auxin production in diploid microsporocytes is necessary and sufficient for early stages of pollen development
  5. 17465
    “…As a result, novel marker genes of PDR were identified, including flavin containing monooxygenase 2. Furthermore, several common or specific genes, pathways and TFs have been recovered for active and inactive FVMs. …”
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    Comprehensive analysis of gene expression profiles associated with proliferative diabetic retinopathy
  6. 17466
    “…In this study, we hypothesized that human quinone reductase 2 (hQR2), known to act as a flavin redox switch upon binding to the broadly used antimalarial chloroquine, could be involved in the activity of the redox-active indolone derivatives. …”
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    Role of Quinone Reductase 2 in the Antimalarial Properties of Indolone-Type Derivatives
  7. 17467
    “…However, CREG does not have enzymatic activities because it cannot bind to the cofactor flavin mononucleotide. Although CREG can be secreted, it is mainly an intracellular protein localized in the endocytic-lysosomal compartment. …”
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    The Structure and Biological Function of CREG
  8. 17468
    “…The analysis revealed 114 proteins (15 toxin families) and 176 proteins (20 toxin families) in Malaysian Calloselasma rhodostoma and Ophiophagus hannah species, respectively. Flavin monoamine oxidase, phospholipase A(2), phosphodiesterase, snake venom metalloproteinase, and serine protease toxin families were identified in both venoms. …”
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    Proteomic Characterization of Two Medically Important Malaysian Snake Venoms, Calloselasma rhodostoma (Malayan Pit Viper) and Ophiophagus hannah (King Cobra)
  9. 17469
    “…d-amino acid oxidase (DAO) is a flavin adenine dinucleotide (FAD)–dependent oxidase metabolizing neutral and polar d-amino acids. …”
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    d-amino acid oxidase promotes cellular senescence via the production of reactive oxygen species
  10. 17470
    “…Of note are the recent studies of cytochrome P450 reductases (CPR)–P450 (CYP) endoplasmic reticulum redox chains, showing the relationship between dynamics and electron flow through flavin and haem redox centres and the impact this has on monooxygenation chemistry. …”
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    Tripping the light fantastic in membrane redox biology: linking dynamic structures to function in ER electron transfer chains
  11. 17471
    “…The bacterial flavin adenine dinucleotide (FAD)-dependent glucose dehydrogenase complex derived from Burkholderia cepacia (BcGDH) is a representative molecule of direct electron transfer-type FAD-dependent dehydrogenase complexes. …”
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    X-ray structure of the direct electron transfer-type FAD glucose dehydrogenase catalytic subunit complexed with a hitchhiker protein
  12. 17472
    “…It belongs to a family of reversible decarboxylases that interconvert propenoic or aromatic acids with the corresponding alkenes or aromatic compounds using a prenylated flavin (prFMN) cofactor. This cofactor is suggested to support (de)carboxylation through a reversible 1,3-dipolar cycloaddition process. …”
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    Enzymatic control of cycloadduct conformation ensures reversible 1,3 dipolar cycloaddition in a prFMN dependent decarboxylase
  13. 17473
    “…The results show that a high rate of flavin-enzyme-catalysed water exchange obscures labelling of NADPH from deuterated substrates and that this exchange cannot be accurately accounted for due to exchange between triose- and hexose-phosphates. …”
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    Limitations of Deuterium-Labelled Substrates for Quantifying NADPH Metabolism in Heterotrophic Arabidopsis Cell Cultures
  14. 17474
    “…Applying this classifier model, an accuracy of 89.75% on the popular Flavia leaf dataset was reached. The results obtained by the proposed approach are promising and encouraging in helping Douro wine growers in the automatic task of identifying grape varieties.…”
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    Deep Learning Techniques for Grape Plant Species Identification in Natural Images
  15. 17475
    “…The high resolution structure, solved by NMR-spectroscopy in solution, reveals binding features both common and different from the binding mode of other aptamers with affinity for ligands carrying planar aromatic ring systems such as the malachite green aptamer which binds to the tetramethylrhodamine related dye malachite green or the flavin mononucleotide aptamer.…”
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    Structure of an RNA aptamer in complex with the fluorophore tetramethylrhodamine
  16. 17476
    “…Statistical analysis of the relative abundance of metabolic marker genes and gene family diversity shows that oxygenic photosynthesis, carbon fixation, and flavin-based electron bifurcation differentiate mats growing in different environmental conditions. …”
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    Environmental control on the distribution of metabolic strategies of benthic microbial mats in Lake Fryxell, Antarctica
  17. 17477
    “…Therefore, bacterial flavin-dependent tryptophan-halogenase genes were transformed into the model organism Arabidopsis thaliana. …”
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    Chlorinated Auxins—How Does Arabidopsis Thaliana Deal with Them?
  18. 17478
    por Jia, Xun, Osborn, Lucas J., Wang, Zeneng
    Publicado 2020
    “…TMA can be oxidized as trimethylamine N-oxide (TMAO) catalyzed by hepatic flavin monooxygenases. Circulating TMAO has been demonstrated to portend a pro-inflammatory state, contributing to chronic diseases such as cardiovascular disease and chronic kidney disease. …”
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    Simultaneous Measurement of Urinary Trimethylamine (TMA) and Trimethylamine N-Oxide (TMAO) by Liquid Chromatography–Mass Spectrometry
  19. 17479
    “…FAD and CoA are accommodated in the DXO/Rai1 active site by adopting folded conformations. The flavin of FAD and the pantetheine group of CoA contact the same region at the bottom of the active site tunnel, which undergoes conformational changes to accommodate the different cap moieties. …”
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    DXO/Rai1 enzymes remove 5′-end FAD and dephospho-CoA caps on RNAs
  20. 17480
    “…Herein, for the first time, we reported the discovery of a series of 5-cyano-6-phenylpyrimidine derivatives as LSD1 inhibitors using flavin adenine dinucleotide (FAD) similarity-based designing strategy, of which compound 14q was finally identified to repress LSD1 with IC(50) = 183 nmol/L. …”
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    Exploration of 5-cyano-6-phenylpyrimidin derivatives containing an 1,2,3-triazole moiety as potent FAD-based LSD1 inhibitors
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