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  1. 17561
    “…Ferredoxin:NADP(+) oxidoreductase from Plasmodium falciparum (PfFNR) catalyzes the NADPH-dependent reduction of ferredoxin (PfFd), which provides redox equivalents for the biosynthesis of isoprenoids and fatty acids in the apicoplast. Like other flavin-dependent electrontransferases, PfFNR is a potential source of free radicals of quinones and other redox cycling compounds. …”
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    Reactions of Plasmodium falciparum Ferredoxin:NADP(+) Oxidoreductase with Redox Cycling Xenobiotics: A Mechanistic Study
  2. 17562
    “…We herein report a host–guest supramolecular strategy based on the incorporation of NADH mimics onto the surface of a metal-organic capsule to encapsulate flavin analogues for catalytic biomimetic monooxygenations in conjunction with enzymes. …”
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    A host–guest approach to combining enzymatic and artificial catalysis for catalyzing biomimetic monooxygenation
  3. 17563
    “…Flavin-mediated photocatalytic oxidations are established in synthetic chemistry. …”
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    Deazaflavin reductive photocatalysis involves excited semiquinone radicals
  4. 17564
    “…DnaG primase of Escherichia coli initiates synthesis of RNA with NADH (the reduced form of nicotinamide adenine dinucleotide) and FAD (flavin adenine dinucleotide) in vitro. These cofactors consist of an ADP core covalently bound to extra moieties. …”
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    Metabolic cofactors NADH and FAD act as non-canonical initiating substrates for a primase and affect replication primer processing in vitro
  5. 17565
    “…The biosynthetic pathway most frequently used in this synthesis is the conversion of tryptophan to indol-3-pyruvic acid (IPA) by tryptophan aminotransferase of Arabidopsis (TAA) followed by the conversion of IPA to IAA by enzymes encoded by YUCCA (YUC) genes of the flavin monooxygenase family; however, it is unclear whether YUC-mediated IAA biosynthesis is involved in SE induction. …”
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    YUCCA-Mediated Biosynthesis of the Auxin IAA Is Required during the Somatic Embryogenic Induction Process in Coffea canephora
  6. 17566
    “…Choline is converted to trimethylamine by gut microbiota and further oxidized to trimethylamine-N-oxide (TMAO) by hepatic flavin monooxygenases. Positive correlation between TMAO and chronic diseases has been reported. …”
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    Protective Effects of Black Raspberry (Rubus occidentalis) Extract against Hypercholesterolemia and Hepatic Inflammation in Rats Fed High-Fat and High-Choline Diets
  7. 17567
    “…Trimethylamine N-oxide, which is generated via the oxidization of gut microbiota-derived trimethylamine by hepatic flavin monooxygenases, is known as an accelerator of atherosclerosis. …”
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    Role of S-Equol, Indoxyl Sulfate, and Trimethylamine N-Oxide on Vascular Function
  8. 17568
    “…In this article, we present the quantum mechanics/molecular mechanics simulation of the rate-limiting step for the serotonin decomposition, which consists of hydride transfer from the serotonin methylene group to the N5 atom of the flavin moiety. Free-energy profiles of the reaction were computed by the empirical valence bond method. …”
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    How Monoamine Oxidase A Decomposes Serotonin: An Empirical Valence Bond Simulation of the Reactive Step
  9. 17569
    “…They harbor the catalytic cofactor flavin adenine dinucleotide (FAD). The light-driven electron transfer from the excited state of the fully-reduced form of FAD to the DNA lesions causes rearrangement of the covalent bonds, leading to the restoration of intact nucleobases. …”
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    Enhanced DNA repair by DNA photolyase bearing an artificial light-harvesting chromophore
  10. 17570
    “…CRY’s photocycle involves reduction of their flavin adenine dinucleotide (FAD)-bound chromophore, which is completely oxidized in the dark and semi to fully reduced in the light signaling-active state. …”
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    Structural insights into photoactivation of plant Cryptochrome-2
  11. 17571
    “…When the involved enzyme flavin mono‐oxygenase 3 is deficient, TMA builds up and is released in the person's sweat, urine, and breath, giving off a strong body odor. …”
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    Impact of trimethylaminuria on daily psychosocial functioning
  12. 17572
    “…Analyses of expression of DNA damage inducible transcript 4 (Ddit4), flavin containing monooxygenase 2 (FMO2) and thioredoxin-interacting protein (Txnip) genes were done. …”
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    Cellular, Molecular and Biochemical Impacts of Silver Nanoparticles on Rat Cerebellar Cortex
  13. 17573
    “…Resistance to these compounds was conferred by mutation of a flavin adenine dinucleotide (FAD)-dependent hydroxylase (Rv1751) that promoted compound catabolism by hydroxylation from molecular oxygen. …”
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    Structure–Activity Relationships of Pyrazolo[1,5-a]pyrimidin-7(4H)-ones as Antitubercular Agents
  14. 17574
    “…Both enzymes require flavin adenine dinucleotide (FAD) as a cofactor. Riboflavin (vitamin B(2)) is a precursor in the synthesis of FAD. …”
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    Maternal vitamin deficiency mimicking multiple acyl-CoA dehydrogenase deficiency on newborn screening
  15. 17575
    “…It has the propensity to bind close to the flavin mononucleotide site of complex I of mitochondria where it traps electron released from nicotinamide adenine dinucleotide (NADH) and elevates intracellular ROS, which suggests that the bridged carbonyl in BBT plays a crucial role in the acceptance of electron from NADH. …”
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    Power of an Organic Electron Acceptor in Modulation of Intracellular Mitochondrial Reactive Oxygen Species: Inducing JNK- and Caspase-Dependent Apoptosis of Cancer Cells
  16. 17576
    por Aminov, Rustam
    Publicado 2021
    “…High-level resistance was achieved only after the acquisition of flavin-dependent monooxygenase-encoding genes from the environmental microbiota. …”
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    Acquisition and Spread of Antimicrobial Resistance: A tet(X) Case Study
  17. 17577
    “…The biliverdin reductase B (BLVRB) class of enzymes catalyze the NADPH-dependent reduction of multiple flavin substrates and are emerging as critical players in cellular redox regulation. …”
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    Modulating Enzyme Function via Dynamic Allostery within Biliverdin Reductase B
  18. 17578
    “…We observed both in glycerol and in sucrose media that the stages of luciferase binding with flavin and aldehyde, in contrast to oxygen, are diffusion-limited. …”
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    Mechanisms of Viscous Media Effects on Elementary Steps of Bacterial Bioluminescent Reaction
  19. 17579
    “…Herein, we characterized the structural and functional consequences of two mutations (the cancer-associated P187S and the phosphomimetic S82D) on different ligation states which are relevant to flavin binding, intracellular stability and catalysis of the disease-associated NQO1 flavoprotein. …”
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    Structural basis of the pleiotropic and specific phenotypic consequences of missense mutations in the multifunctional NAD(P)H:quinone oxidoreductase 1 and their pharmacological rescue
  20. 17580
    “…A new bioanode was prepared through covalently modifying flavin-adenine-dinucleotide-dependent glucose dehydrogenase and azure A with pendant glycidyl groups of poly(glycidyl methacrylate). …”
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    Self-Powered Diaper Sensor with Wireless Transmitter Powered by Paper-Based Biofuel Cell with Urine Glucose as Fuel
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