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  1. 17621
    “…Lipid storage myopathy due to flavin adenine dinucleotide synthetase 1 (FLAD1) deficiency is an autosomal recessive error of metabolism that causes variable mitochondrial dysfunction. …”
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    Detection of FLAD1 mutations and lipid storage myopathy in a 5-year-old boy: a case report study
  2. 17622
    “…The MP-pH 7.8 group showed significant protection, evidenced by bile production, diminished tissue injury, and reduced flavin mononucleotide leakage, and further analysis by scanning electron microscopy revealed a well-preserved structure of the mitochondrial cristae. …”
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    Exploration of Optimal pH in Hypothermic Machine Perfusion for Rat Liver Grafts Retrieved after Circulatory Death
  3. 17623
    “…Flavin adenine dinucleotide (FAD) interacts with flavoproteins to mediate oxidation-reduction reactions required for cellular energy demands. …”
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    Vitamin B2 enables regulation of fasting glucose availability
  4. 17624
    “…And the most important components of the electron respiratory chain are hydrogen carrier, which is mainly composed of iron-sulfur proteins (Fe-S), flavin dehydrogenase (FAD), molybdenum binding protein and cytochromes. …”
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    Sources, Components, Structure, Catalytic Mechanism and Applications: a Critical Review on Nicotinate Dehydrogenase
  5. 17625
    “…Aspartate is found to bind in an entry chamber that is close to but not in direct contact with the flavin. It is recognized by an extensive H-bond network that explains the enzyme’s strict substrate-selectivity. …”
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    A biosynthetic aspartate N-hydroxylase performs successive oxidations by holding intermediates at a site away from the catalytic center
  6. 17626
    “…The PQ mediator enhances electron transfer between the electrode surface and the GOx enzyme’s flavin adenine dinucleotides. The functional microparticles are directly applied to the printed electrode. …”
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    Glucose Oxidase/Egg White Protein Microparticles with a Redox Mediator for Glucose Biosensors on a Screen-Printed Electrode and a Decomposable Electrode
  7. 17627
    “…Analysis of a re-engineered CcaS in Escherichia coli demonstrated green/red photoswitching with phytochromobilin, a chromophore endogenous to plants, but also revealed a blue light response likely derived from a flavin-binding LOV-like domain. We deployed Highlighter in transiently transformed Nicotiana benthamiana for optogenetic control of fluorescent protein expression. …”
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    Highlighter: An optogenetic system for high-resolution gene expression control in plants
  8. 17628
    “…We show that BXD biosynthesis in A. squarrosa and L. galeobdolon utilize a dual-function flavin-containing monooxygenase in place of two distinct cytochrome P450s, as is the case in the grasses. …”
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    Reinventing metabolic pathways: Independent evolution of benzoxazinoids in flowering plants
  9. 17629
    “…We found extensive Lys glycerophosphorylations (pgK), as well as modification with glycerylphosphorylethanolamine on Glu (gpetE) and flavin mononucleotide on His (fmnH). The functionality of these metabolite-derived PTMs is demonstrated during metabolic dysfunction-associated steatotic liver disease (MASLD) development in mice. …”
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    Unbiased Phosphoproteome Mining Reveals New Functional Sites of Metabolite-Derived PTMs Involved in MASLD Development
  10. 17630
    por Price, Winston H.
    Publicado 1947
    “…A solution containing biotin, guanine, adenine, β-alanine, riboflavin, uracil, pyridoxamine, guanylic acid, adenylic acid, yeast nucleic acid, choline, p-aminobenzoic acid, a flavin component from liver, ribose, thymine, xanthine, folic acid, inositol, p-aminophenyl alanine, pantothentic acid and a strepogenin concentrate cannot replace broth or yeast extraction in increasing phage formation in the synthetic medium of Fildes. 7. …”
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    BACTERIOPHAGE FORMATION WITHOUT BACTERIAL GROWTH : II. THE EFFECT OF NIACIN AND YEAST EXTRACT ON PHAGE FORMATION AND BACTERIAL GROWTH IN THE PRESENCE OF PENICILLIN
  11. 17631
    “…The purified enzyme was shown to be a soluble dimeric flavoprotein consisting of subunits of 50 kDa and contains non-covalently bound flavin adenine dinucleotide as a cofactor. From all substrates, the highest catalytic efficiency was found with putrescine (K (M) = 8.2 μM, k (cat) = 26 s(−1)). …”
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    Discovery and characterization of a putrescine oxidase from Rhodococcus erythropolis NCIMB 11540
  12. 17632
    “…There is no evidence that the flavin cofactor directly participates in the reaction. …”
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    Substrate Binding in the FAD-Dependent Hydroxynitrile Lyase from Almond Provides Insight into the Mechanism of Cyanohydrin Formation and Explains the Absence of Dehydrogenation Activity(,)
  13. 17633
    “…The structural comparison with a cryptochrome protein bound to flavin adenine dinucleotide and single-stranded DNA provides important insight into the mechanism of RNA primer synthesis by the primase.…”
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    Shared Active Site Architecture between the Large Subunit of Eukaryotic Primase and DNA Photolyase
  14. 17634
    “…Subsequently, a profound flavin deficiency in spite of a normal dietary riboflavin intake was established in the plasma of all three children, suggesting a riboflavin transporter defect. …”
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    Brown-Vialetto-Van Laere and Fazio Londe syndrome is associated with a riboflavin transporter defect mimicking mild MADD: a new inborn error of metabolism with potential treatment
  15. 17635
    “…Despite these diverse functions, PLs/CRYs preserve a common structural fold, a dependence on flavin adenine dinucleotide (FAD) and an internal photoactivation mechanism(3; 6). …”
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    Structure of Full-length Drosophila Cryptochrome
  16. 17636
    “…Here, we report the identification of a novel metabolite that is synthesized by a potential gene cluster containing an indole prenyltransferase gene (SCO7467) and a flavin-dependent monooxygenase (FMO) gene (SCO7468), which were mined from the genome of Streptomyces coelicolor A3(2). …”
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    Novel Tryptophan Metabolism by a Potential Gene Cluster That Is Widely Distributed among Actinomycetes
  17. 17637
    “…Enzymatic assay carried out on cell-free lysates of MNA grown cells confirmed N-demethylation reaction is the first step of MNA degradation with the formation of 4-NA and formaldehyde products. Flavin-dependent transformation of 4-NA to 4-AP in cell extracts demonstrated that the second step of MNA degradation is a monooxygenation. …”
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    Aerobic Degradation of N-Methyl-4-Nitroaniline (MNA) by Pseudomonas sp. Strain FK357 Isolated from Soil
  18. 17638
    “…The peak mRNA levels of GI and FKF1 (Flavin-binding Kelch domain F box protein 1) and the mRNA levels of CO and FT (Flowering locus T) changed under drought stress. …”
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    The Suppression of WRKY44 by GIGANTEA-miR172 Pathway Is Involved in Drought Response of Arabidopsis thaliana
  19. 17639
    “…[Image: see text] The crystal structure of the flavin mononucleotide (FMN)-containing redox partner to P450cin, cindoxin (Cdx), has been determined to 1.3 Å resolution. …”
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    Crystal Structure of Cindoxin, the P450cin Redox Partner
  20. 17640
    “…A functionally active AOx was achieved by incubating the apo-AOx with flavin adenine dinucleotide (FAD) for ∼80 h at 16°C and pH 9.0. …”
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    Molecular Characterization and Expression of a Novel Alcohol Oxidase from Aspergillus terreus MTCC6324
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