“…This study aimed to determine natural Wolbachia infections in different mosquito species across Hainan Province, China. METHODS: Adult mosquitoes were collected using light traps, human landing catches and aspirators in five areas in Hainan Province from May 2020 to November 2021. …”
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“…The above results indicate that upwelling dominated the changes in Chl-a concentration in the Hainan northeast upwelling area during the typhoon-free period. …”
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“…Here, 8-hydroxylinalool was found to be one of the major linalool-derived aroma compounds in Camellia sinensis var. assamica ‘Hainan dayezhong’, a tea plant grown in Hainan Province, China. …”
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“…Three new genera and eleven new species are reported from Hainan Island, China. The new genera are Logunattusgen. nov., including L.dufuisp. nov. (♂), and the generotype L.libaiisp. nov. (♂♀), Qiongattusyuanyeaegen. et sp. nov. (♂♀), and Spiralembolusgen. nov., including the generotype S.yinggelingsp. nov. (♂♀), and S.yuisp. nov. (♂♀). …”
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“…The incomplete synthesis of O-glycans or the formation of truncated glycans such as the Tn-antigen (Thomsen nouveau; GalNAcα- Ser/Thr), its sialylated version the STn-antigen (sialyl-Tn; Neu5Acα2–6GalNAcα-Ser/Thr) and the elongated T-antigen (Thomsen–Friedenreich; Galβ1-3GalNAcα-Ser/Thr) has been shown to be associated with tumour progression and metastatic state in many human cancers. …”
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“…To identify small molecules that promote host survival by altering the host-pathogen dynamic, we conducted an in vivo chemical screen using zebrafish embryos and found that treatment with 3-hydroxy-kynurenine protects from lethal gram-negative bacterial infection. 3-hydroxy-kynurenine, a metabolite produced through host tryptophan metabolism, has no direct antibacterial activity but enhances host survival by restricting bacterial expansion in macrophages by targeting kainate-sensitive glutamate receptors. These findings reveal new mechanisms by which tryptophan metabolism and kainate-sensitive glutamate receptors function and interact to modulate immunity, with significant implications for the coordination between the immune and nervous systems in pathological conditions.…”
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“…Kainate receptors (KARs) are key regulators of neuronal excitability and synaptic transmission. …”
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“…Here, we aim to gain a better understanding of malaria elimination by assessing and quantifying the relative effects of longitudinal changes in specific antimalarial interventions, socioeconomic development approaches, and malaria vectors on malaria prevalence in Hainan during the 1986–2009 pre-elimination period. …”
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“…CONCLUSION: In this study, we gained insights into the spatiotemporal epidemiological dynamics, pivotal environmental drivers, and potential risk map of scrub typhus in Hainan Province. …”
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“…In this study, the community structure of the necrophagous flies on Hainan Island was investigated in detail according to the geographical environment. …”
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“…OBJECTIVE: This study aims to assess the prevalence of Helicobacter pylori (Hp) infection at the household level in Hainan Province in China and identify the factors that contribute to its spread. …”
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“…BACKGROUND: Hainan is one of the provinces most severely affected by malaria epidemics in China. …”
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“…Following kainate (KA)-induced epilepsy, rat hippocampal neurons strongly express immediate early gene (IEG) products, i.e., c-FOS and c-JUN, and neural stress protein, HSP72. …”
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“…Phosphorylation or SUMOylation of the kainate receptor (KAR) subunit GluK2 have both individually been shown to regulate KAR surface expression. …”
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“…Kainate receptors (KARs) are a class of ionotropic glutamate receptors that are expressed throughout the central nervous system. …”
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“…However, the GluR5-containing kainate receptor-specific antagonist (S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl) pyrimidine-2,4-dione (UBP302) abolished oscillations–evidence that glutamatergic receptor involvement is predominantly kainate receptor mediated. …”
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“…Also, in the aged neurons, kainate induced significantly larger Ca(2+) signals. …”
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