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241por Nair, Jayaprakash K., Attarwala, Husain, Sehgal, Alfica, Wang, Qianfan, Aluri, Krishna, Zhang, Xuemei, Gao, Minggeng, Liu, Ju, Indrakanti, Ramesh, Schofield, Sally, Kretschmer, Philip, Brown, Christopher R., Gupta, Swati, Willoughby, Jennifer L.S., Boshar, Julie A., Jadhav, Vasant, Charisse, Klaus, Zimmermann, Tracy, Fitzgerald, Kevin, Manoharan, Muthiah, Rajeev, Kallanthottathil G., Akinc, Akin, Hutabarat, Renta, Maier, Martin A.“…Covalent attachment of a synthetic triantennary N-acetylagalactosamine (GalNAc) ligand to chemically modified siRNA has enabled asialoglycoprotein (ASGPR)-mediated targeted delivery of therapeutically active siRNAs to hepatocytes in vivo. …”
Publicado 2017
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242por Yan, Quanshu, Shi, Xuefa, Metcalfe, Ian, Liu, Shengfa, Xu, Taoyu, Kornkanitnan, Narumol, Sirichaiseth, Thanyapat, Yuan, Long, Zhang, Ying, Zhang, Hui“…We suggest that the post-spreading intraplate volcanism in the SCS region was induced by a Hainan mantle plume which spread westwards to the Paleozoic Sukhothai arc terrane.…”
Publicado 2018
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243Unique Microbial Diversity and Metabolic Pathway Features of Fermented Vegetables From Hainan, Chinapor Peng, Qiannan, Jiang, Shuaiming, Chen, Jieling, Ma, Chenchen, Huo, Dongxue, Shao, Yuyu, Zhang, Jiachao“…Herein, we applied high-throughput sequencing and culture-dependent technology to describe the diversities of microbiota and identify core microbiota in fermented vegetables from different areas of Hainan Province, and abundant metabolic pathways in the fermented vegetables were simultaneously predicted. …”
Publicado 2018
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244por Albuquerque, Mário S. de Souza, Filho, Antônio F. da Silva, Cordeiro, Marina Ferraz, de Souza, Maria de Fátima Deodato, Quirino, Michael W. L., Lima, Luiza R. Amorim, Pitta, Maira G. da Rocha, Martins, Mário R., Rêgo, Moacyr J. B. de MeloEnlace del recurso
Publicado 2018
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245por Zhang, Kaiyan, Zhong, Qionglei, Chen, Siying, Guo, Chuanxian, Xu, Yan, Liu, Yang, Sun, Wen, Yan, Yijie, Zhao, Puning“…PURPOSE: The aim of this study was to investigate the prevalence of age-related macular degeneration (AMD) and the risk factors in the residents aged ≥50 years in Hainan Province. METHODS: Random sampling was carried out in four separated cities in Hainan Province in 2015. …”
Publicado 2017
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247por Wu, Yue, Wang, Shanshan, Chen, Yunchun, Li, Lihua, Wang, Wenqi, Zhou, Huanhuan, Zhang, You, Zhang, Lei, Cui, Xiuji, Lv, Gang, Yin, Feifei“…In this study, we sequenced and analyzed the complete genome of a genetic variant of a rodent TTV, RoTTV3-HMU1 (Hainan Medical University 1). The virus was found in a rat (Rattus norvegicus) in a residential area of Hainan Island, China.…”
Publicado 2018
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248por Sewing, Sabine, Gubler, Marcel, Gérard, Régine, Avignon, Blandine, Mueller, Yasmin, Braendli-Baiocco, Annamaria, Odin, Marielle, Moisan, Annie“…Nevertheless, GalNAc conjugation does not prevent accumulation of AONs in the kidney cortex, and GalNAc-conjugated AONs might cause kidney toxicities, for example, under conditions of ASGPR saturation. …”
Publicado 2018
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249“…Previously, we reported a phylogenetic study of 98 Burkholderia pseudomallei clinical isolates from Hainan, China. Here, we update the B. pseudomallei strain library with 52 strains from newly identified cases dating from 2014 to 2017, analysed by multilocus sequence typing. …”
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250“…Three new species of the genus Flexicrurum Tong & Li, 2007, from Hainan Island, China are described: F.wuzhishanensesp. nov. (♂♀), F.yangjiaosp. nov. (♂♀), and F.qishisp. nov. (♂♀). …”
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251“…Hainan/Eksotika papaya is a popular cultivated plant in Hainan Island, China. …”
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252“…Kainate (KA) receptors (KAR) have important modulatory roles of synaptic transmission. …”
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253por Gauthier, Laura, Varache, Mathieu, Couffin, Anne-Claude, Lebrun, Colette, Delangle, Pascale, Gateau, Christelle, Texier, Isabelle“…Different molar percentages of GalNAc-functionalized surfactant (0%, 2%, 5%, and 14%) were used in the formulation. …”
Publicado 2019
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254por Ye, Zhouchen, Wu, Yougen, Ul Haq Muhammad, Zeeshan, Yan, Wuping, Yu, Jing, Zhang, Junfeng, Yao, Guanglong, Hu, Xinwen“…To reveal novel insights into the characters during the maturation period of this plant as well as the molecular basis of fatty acid biosynthesis and degradation, we conducted a conjoint analysis of the transcriptome and proteome of C. oleifera seeds from Hainan Island. Using RNA sequencing (RNA-seq) technology and shotgun proteomic method, 59,391 transcripts and 40,500 unigenes were obtained by TIGR Gene Indices Clustering Tools (TGICL), while 1691 protein species were identified from Mass Spectrometry (MS). …”
Publicado 2020
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255por Barna, Lilla, Walter, Fruzsina R., Harazin, András, Bocsik, Alexandra, Kincses, András, Tubak, Vilmos, Jósvay, Katalin, Zvara, Ágnes, Campos-Bedolla, Patricia, Deli, Mária A.“…BACKGROUND: Excitotoxicity is a central pathological pathway in many neurological diseases with blood–brain barrier (BBB) dysfunction. Kainate, an exogenous excitotoxin, induces epilepsy and BBB damage in animal models, but the direct effect of kainate on brain endothelial cells has not been studied in detail. …”
Publicado 2020
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256por Tsuchida, Akiko, Senda, Motohiro, Ito, Akihiro, Saito, Seiichi, Kiso, Makoto, Ando, Takayuki, Harduin-Lepers, Anne, Matsuda, Akio, Furukawa, Keiko, Furukawa, KoichiEnlace del recurso
Publicado 2020
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257Visualization of live, mammalian neurons during Kainate-infusion using magnetic resonance microscopypor Flint, Jeremy J., Menon, Kannan, Hansen, Brian, Forder, John, Blackband, Stephen J.“…We are also able to report changes in the apparent diffusion of the stratum oriens within the hippocampus—a layer comprised primarily of pyramidal cell axons and basal dendrites—and the spinal cord’s ventral horn following exposure to kainate.…”
Publicado 2020
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258por Wu, Biao, Lei, Zi-Ying, Wu, Kun-Liang, He, Jian-Rong, Cao, Hui-Juan, Fu, Juan, Chen, Feng, Chen, Yuan, Chen, Bao, Zhou, Xiao-Li, Huang, Tao, Wu, Tao, Du, Yong-Guo, Chen, Suo-Xian, Xiao, Fu-Rong, Gao, Zhi-Liang, He, Jing, Lin, Feng, Lin, Bing-Liang“…BACKGROUND: Effective management of imported cases is an important part of epidemic prevention and control. Hainan Province, China reported 168 coronavirus disease 2019 (COVID-19), including 112 imported cases on February 19, 2020, but successfully contained the epidemic within 1 month. …”
Publicado 2020
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259por Li, Siping, Jiang, Feng, Lu, Hong, Kang, Xun, Wang, Yanhong, Zou, Zhen, Wen, Dan, Zheng, Aihua, Liu, Chunxiang, Liu, Qiyong, Kang, Le, Xia, Qianfeng, Cui, Feng“…Hainan is a tropical island in southern China with abundant mosquito species, putting Hainan at risk of mosquito-borne virus disease outbreaks. …”
Publicado 2020
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260“…It is distributed in the dense or open forests of Hainan province, China. Here, we report and characterize the complete plastome of C. laevigatus in an effort to provide genomic resources useful for promoting its systematics research. …”
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