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  1. 2821
    “…To this end, we combined consecutive lectin affinity purification using Maclura pomifera lectin (MPL), jacalin, and Sambucus nigra lectin, which have affinities for the following O-glycans, that have received attention as cancer-related antigens, Tn (GalNAc-Ser/Thr), Sialyl Tn (Siaα2-6GalNAc-Ser/Thr), T (Galβ1-3GalNAc-Ser/Thr), Sialyl T (Siaα2-3Galβ1-GalNAc-Ser/Thr), and di-Sialyl T (Siaα2-3Galβ1-3[Siaα2-6] GalNAc-Ser/Thr), with a unique O-glycoproteomics approach. …”
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    Targeted O-glycoproteomics for the development of diagnostic markers for advanced colorectal cancer
  2. 2822
    “…The LC(50) value of deltamethrin was lower in Haikou than in other locations, which mean the south of Hainan has higher resistance than the north of Hainan. …”
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    Detection of Putative Mutation I873S in the Sodium Channel of Megalurothrips usitatus (Bagnall) Which May Be Associated with Pyrethroid Resistance
  3. 2823
    por Schauwecker, Paula Elyse
    Publicado 2012
    “…RESULTS: In this study, we examined glycemic modulation of kainate-induced seizure sensitivity and its neuropathological consequences. …”
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    The effects of glycemic control on seizures and seizure-induced excitotoxic cell death
  4. 2824
    “…Dry matter intake (DMI), liveweight gain (LWG) and gain:feed were measured weekly. A balance collection was carried out from 14 to 21 d for determination of apparent metabolizable energy (AME), ME:gain, dry matter retention, oil and neutral detergent fibre (NDF) digestibility. …”
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    Chemical and Physical Predictors of the Nutritive Value of Wheat in Broiler Diets
  5. 2825
    “…Chondroitin/dermatan sulfate (CS/DS) proteoglycans consist of unbranched sulfated polysaccharide chains of repeating GalNAc-GlcA/IdoA disaccharide units, attached to serine residues on specific proteins. …”
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    Chondroitin / Dermatan Sulfate Modification Enzymes in Zebrafish Development
  6. 2826
    “…RESULTS: Hypermethylation levels of ASCL1,LHX8 and ST6GALNAC5 increased with severity of cervical disease. …”
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    Detection of hypermethylated genes as markers for cervical screening in women living with HIV
  7. 2827
    “…Active GalNAc–MASP3–siRNA conjugates were identified, and in vivo silencing of liver MASP-3 mRNA was demonstrated in healthy mice. …”
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    Targeting of Liver Mannan-Binding Lectin–Associated Serine Protease-3 with RNA Interference Ameliorates Disease in a Mouse Model of Rheumatoid Arthritis
  8. 2828
    “…SLN360 is a liver-targeted N-acetyl galactosamine (GalNAc)-conjugated small interfering RNA (siRNA) with a promising profile for addressing lipoprotein (a)-related cardiovascular risk. …”
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    Preclinical Toxicological Assessment of A Novel siRNA, SLN360, Targeting Elevated Lipoprotein (a) in Cardiovascular Disease
  9. 2829
    por Riedl, Bettina, Schmid, Walther
    Publicado 2018
    “…Synthetic approaches towards N-acetylgalactosamine (GalNAc) have been attracting considerable interest since this compound is known for its pivotal role in cell–cell interaction and receptor induced cell signaling. …”
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    A stereoselective and flexible synthesis to access both enantiomers of N-acetylgalactosamine and peracetylated N-acetylidosamine
  10. 2830
    “…Here, we describe a protocol to develop chemical, bioorthogonal reporters for the activity of the GalNAc-T family of glycosyltransferases using a tactic termed bump-and-hole engineering. …”
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    Bump-and-hole engineering of human polypeptide N-acetylgalactosamine transferases to dissect their protein substrates and glycosylation sites in cells
  11. 2831
    “…Application of one of our most effective designs to generate a GalNAc-siRNA targeting human HSD17B13 led to ∼80% silencing that persisted for at least 14 weeks after administration of a single 3 mg/kg subcutaneous dose in transgenic mice. …”
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    Impact of stereopure chimeric backbone chemistries on the potency and durability of gene silencing by RNA interference
  12. 2832
    “…Adult patients with ACI who were admitted to the First Affiliated Hospital of Hainan Medical College, the Second Affiliated Hospital of Hainan Medical College, Hainan Provincial People’s Hospital, and the Department of Neurology of Haikou People’s Hospital from January 2008 to December 2018 were enrolled. …”
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    The clinical characteristics of acute cerebral infarction patients with thalassemia in a tropic area in China
  13. 2833
    “…It can be indirectly proved that the Li nationality in Hainan is a descendant of the ancient Baiyue ethnic group, which provides circumstantial evidence for the migration history of the Li nationality in Hainan, and also provides basic data for the advanced protection of Shanlan upland rice, and the innovative utilization of germplasm resources.…”
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    Genetic Diversity and Relationship of Shanlan Upland Rice Were Revealed Based on 214 Upland Rice SSR Markers
  14. 2834
    “…Gating of AMPA- and kainate-selective ionotropic glutamate receptors can be defined in terms of ligand affinity, efficacy and the rate and extent of desensitization. …”
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    Correlating efficacy and desensitization with GluK2 ligand-binding domain movements
  15. 2835
    “…The O-glycan moiety was characterized as Gal(β1–3)-GalNAc(β1–4)-GalNAc(β1–4)-GalNAcα1-Thr(268); modelling suggested that O-glycosylation has a notable effect on the conformation of MOMP and this modulates BgAg-binding capacity. …”
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    A novel O-linked glycan modulates Campylobacter jejuni major outer membrane protein-mediated adhesion to human histo-blood group antigens and chicken colonization
  16. 2836
    “…A goat intestinal permeation study revealed that the provesicular formulation (F4) with an SP:CH ratio of 5:5 gave higher cumulative amount of drug permeated at 48 h compared to Glinate™ 60 and control. A pharmacodynamic study in streptozotocin-induced diabetic rats confirmed that formulation F4 significantly (P<0.05) reduced blood glucose levels in comparison to Glinate 60. …”
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    Development and in vitro/in vivo evaluation of controlled release provesicles of a nateglinide–maltodextrin complex
  17. 2837
    “…We have identified the most abundant N-linked and O-GalNAc CHO glycoproteins, obtained the weighted frequency of N-linked and O-GalNAc glycosites across the CHO cell proteome, and have derived stoichiometric coefficients for NS consumption towards CHO cell glycosylation. …”
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    A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation
  18. 2838
    “…Here we examined whether a combination of two glutamate receptor antagonists, NBQX and ifenprodil, acting at different receptor subtypes, exerts antiepileptogenic effects in the intrahippocampal kainate mouse model of epilepsy. These drugs were administered over 5 days following kainate. …”
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    A combination of NMDA and AMPA receptor antagonists retards granule cell dispersion and epileptogenesis in a model of acquired epilepsy
  19. 2839
    “…The gainer has a mass block which is used to increase its sensitivity to vibration. …”
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    Design and Analysis of a Combined Strain–Vibration–Temperature Sensor with Two Fiber Bragg Gratings and a Trapezoidal Beam
  20. 2840
    “…In the present study, an effective, safe and biocompatible survivin siRNA encapsulated, GalNAc decorated PEGylated PLGA nanoconjugates (NCs) viz., GalNAc@PEG@siRNA-PLGA were engineered and their synergistic antitumor efficacy was evaluated for targeted delivery in HCC bearing experimental mice. …”
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    Therapeutic potential of functionalized siRNA nanoparticles on regression of liver cancer in experimental mice
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