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  1. 321
    “…BACKGROUND: Hainan is the largest island of the Indo-Burma Biodiversity Hotspot and has the best preserved and most extensive tropical forests in China. …”
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    Begonia wuzhishanensis (sect. Diploclinium, Begoniaceae), a new species from Hainan Island, China
  2. 322
    “…Based on these findings, the unconjugated and GalNAc(3)-conjugated 2′-MOE-ASOs would have no or minimal DDI with small drug molecules via any major CYP enzyme or drug transporters at clinically relevant exposures.…”
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    Assessment of the Drug Interaction Potential of Unconjugated and GalNAc(3)-Conjugated 2′-MOE-ASOs
  3. 323
    “…A new tree frog species of the genus Scinax from the interfluve between the Purus and Madeira rivers, Brazilian Amazonia, is described and illustrated. …”
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    A new species of Scinax from the Purus-Madeira interfluve, Brazilian Amazonia (Anura, Hylidae)
  4. 324
    “…The polypeptide GalNAc-transferases (GalNAc-Ts), that initiate mucin-type O-glycosylation, consist of a catalytic and a lectin domain connected by a flexible linker. …”
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    The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences
  5. 325
    “…In this study, we applied a molecular method (high-throughput internal transcribed spacer 2 region of ribosomal RNA gene amplicon sequencing) to explore diversity and flexibility of Symbiodinium associated with Galaxea fascicularis, an ecologically important scleractinian coral species collected at five locations around Hainan Island, South China Sea. The results revealed a high diversity of Symbiodinium subclades with C2r and D17 being dominant in G. fascicularis. …”
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    Temperature-Driven Local Acclimatization of Symbiodnium Hosted by the Coral Galaxea fascicularis at Hainan Island, China
  6. 326
    “…CONCLUSION: Our results indicate that the methylation profile combination of HKR1, ROD1, and NLRC5 could be a promising biomarker for aging in Hainan centenarians. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12920-018-0334-1) contains supplementary material, which is available to authorized users.…”
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    Methylation of the genes ROD1, NLRC5, and HKR1 is associated with aging in Hainan centenarians
  7. 327
    “…Small interfering RNAs (siRNAs) conjugated to a trivalent N-acetylgalactosamine (GalNAc) ligand are being evaluated in investigational clinical studies for a variety of indications. …”
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    Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity
  8. 328
    “…We elucidated the mechanisms underlying the kainate receptor (KAR)-mediated facilitatory modulation of synaptic transmission in the cerebellum. …”
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    Cerebellar Kainate Receptor-Mediated Facilitation of Glutamate Release Requires Ca(2+)-Calmodulin and PKA
  9. 329
    “…In the present study the prognostic significance of GalNAc-T6 was investigated in patients with CRC patients. …”
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    Polypeptide-GalNAc-T6 expression predicts better overall survival in patients with colon cancer
  10. 330
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    The concrete evidence of flexistyly in Plagiostachys: pollination biology of a wild ginger on Hainan Island, China
  11. 331
    “…Fragile X syndrome is caused by the loss of fragile X mental retardation protein (FMRP). Kainate receptor (KAR) is a subfamily of ionotropic glutamate receptors (iGluR) that acts mainly as a neuromodulator of synaptic transmission and neuronal excitability. …”
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    Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice
  12. 332
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    Association between Age-Related Macular Degeneration and Lens Opacity in Senior Population in Hainan Province
  13. 333
    “…We question whether the expression of GalNAc-T3, the only known O-GalNAc-transferase present in germ cells, is correlated with qualitative and functional parameters of spermatozoa. …”
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    Expression of the O-Glycosylation Enzyme GalNAc-T3 in the Equatorial Segment Correlates with the Quality of Spermatozoa
  14. 334
    “…The velvet belly lanternshark (Etmopterus spinax) is a small deep-sea shark commonly found in the Eastern Atlantic and the Mediterranean Sea. …”
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    De novo transcriptome analyses provide insights into opsin-based photoreception in the lanternshark Etmopterus spinax
  15. 335
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    Correction to: Detection and epidemic dynamic of ToCV and CCYV with Bemisia tabaci and weed in Hainan of China
  16. 336
    “…No apparent functional impact on mitochondria and no significant accumulation of 2′-F-monomers were observed after weekly administration of two GalNAc–siRNA conjugates in rats for ∼2 years. Taken together, the results support the conclusion that 2′-F nucleotides can be safely applied for the design of metabolically stabilized therapeutic GalNAc–siRNAs with favorable potency and prolonged duration of activity allowing for low dose and infrequent dosing.…”
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    Safety evaluation of 2′-deoxy-2′-fluoro nucleotides in GalNAc-siRNA conjugates
  17. 337
    “…The total GC content of Hainan C. oleifera’s chloroplast genome was 37.29%. …”
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    Determination of the evolutionary pressure on Camellia oleifera on Hainan Island using the complete chloroplast genome sequence
  18. 338
    “…Key vanilla flavors, vanillin precursors and main enzymes during the curing process of Hainan vanilla beans were also analyzed. Hundreds of metabolites were detected based on metabolic analyses of a widely targeted metabolome technique, compared with blanched vanilla beans (BVB), sweating vanilla beans (SVB) and drying vanilla beans (DVB), the total peak intensity of cured vanilla beans (CVB) is on the rise. …”
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    Metabolite Transformation and Enzyme Activities of Hainan Vanilla Beans During Curing to Improve Flavor Formation
  19. 339
    “…The genus Scinax currently includes more than 120 species, recovered in two major clades, the S. catharinae and the S. ruber clades. …”
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    A review of the elusive bicolored iris Snouted Treefrogs (Anura: Hylidae:Scinax uruguayus group)
  20. 340
    “…Two regions of the gene were analyzed in 290 Gannan yaks: A region spanning exon 24-intron 24 and a region spanning exon 34. …”
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    Variation in the Fatty Acid Synthase Gene (FASN) and Its Association with Milk Traits in Gannan Yaks
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