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3841por Chen, Jing, Wang, Zhuo, Jia, Xuejing, Li, Rui, Chen, Jianping, Liu, Xiaofei, Song, Bingbing, Zhong, Saiyi, Qi, Yi“…Two heparinoid compounds were obtained from shrimp head, and the main fraction F1 was →4)-GlcA-(1→3)-GalNAc-(1→ with Ara, while the minor fraction F2 composed mainly of the backbone as →4)-β-D-GlcA (or IdoA)-(1→4)-β-D-GlcN (or GlcNAc)-(1→. …”
Publicado 2022
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3842“…This article aims to summarize the development and challenges of real-world data (RWD) and real-world evidence (RWE) in China and introduce a unique opportunity for medical devices to gain accelerated regulatory approval in China by utilizing RWE generated in a free trade pilot zone “Boao Lecheng” in Hainan Province. …”
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3843por Waśniowski, Paweł, Czuczejko, Jolanta, Chuchra, Michał, Wędrowski, Mateusz, Marciniak, Dawid, Sobiak, Stanisław, Małkowski, Bogdan“…The synthesis consists of the following steps: (a) binding of the fluoride anion (18)F(−) on an anion exchange column; (b) elution with TBAHCO(3)(−); (c) nucleophilic fluorination to the ABX 1336 precursor; (d) purification of the intermediate product on the C18ec column; (e) Baeyer–Villiger oxidation; (f) hydrolysis; and (gfinal purification of the crude product on a semipreparative column. …”
Publicado 2022
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3844por Růžička, Jan, Jakubec, Pavel, Mahlerová, Karolina, Šípková, Hana, Nishikawa, Masaaki“…Diamesus osculans is reported for the first time from India: Uttarakhand, China: Anhui, Hainan, Hunan, Jiangxi, Shaanxi and Zhejiang Provinces, and Australia: Victoria; it is also recently confirmed from Taiwan, being sympatric in distribution there with D. bimaculatus. …”
Publicado 2023
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3845por Lin, Xiaoyan, Wu, Bingsun, Wang, Jingjing, Wang, Guoan, Chen, Zixun, Liang, Yongyi, Liu, Jiexi, Wang, Hao“…The leaf carbon content (LCC) and intrinsic WUE of 424 plant samples (from 312 plant species) on Hainan Island were measured to examine their relationship with geographical and climatic factors in herbs, trees, vines and ferns. …”
Publicado 2023
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3846por Shi, Xuezhong, Wu, Meina, Jia, Xiaocan, Bao, Junzhe, Wang, Yuping, Yang, Chaojun, Yu, Mengdie, Yang, Yongli“…In recent years, the under-5 LRI incidence rate has decreased significantly in 11 provinces (Guangdong, Guangxi, Guizhou, Hainan, Heilongjiang, Jiangxi, Qinghai, Sichuan, Xinjiang, Xizang, and Zhejiang) and remained stable in the other 22 provinces. …”
Publicado 2023
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3847“…In contrast, 12 weeks of diabetes decreased the transcript levels of several genes, including two glutamate transporters, four out of five N-methyl-D-aspartate (NMDA) receptor subunits, and all five kainate receptor subunits. Diabetes had a greater effect on gene expression of NMDA and kainate receptor subunits than on the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor subunits, for which only GRIA4 significantly decreased after 12 weeks. …”
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3848“…In Exp. 2, pigs fed the SDBP diet had greater (P < 0.05) BW, ADG, and ADFI at d 7 and 14 compared with pigs fed the other diets. Gain:feed did not differ significantly among diets. …”
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3849por Badri, Prajakta, Jiang, Xuemin, Borodovsky, Anna, Najafian, Nader, Kim, Jae, Clausen, Valerie A., Goel, Varun, Habtemariam, Bahru, Robbie, Gabriel J.“…BACKGROUND: Cemdisiran, an N-acetylgalactosamine (GalNAc) conjugated RNA interference (RNAi) therapeutic, is currently under development for the treatment of complement-mediated diseases by suppressing liver production of complement 5 (C5) protein. …”
Publicado 2020
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3850“…METHODS: From January to December 2021, the Women and Children Medical Center of Hainan Province collected 2389 samples of cervical exfoliated cells and vaginal swab specimens from gynecologic outpatients. …”
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3851por Gonzalez-Rodriguez, Edgar, Zol-Hanlon, Mia, Bineva-Todd, Ganka, Marchesi, Andrea, Skehel, Mark, Mahoney, Keira E., Roustan, Chloë, Borg, Annabel, Di Vagno, Lucia, Kjær, Svend, Wrobel, Antoni G., Benton, Donald J., Nawrath, Philipp, Flitsch, Sabine L., Joshi, Dhira, González-Ramírez, Andrés Manuel, Wilkinson, Katalin A., Wilkinson, Robert J., Wall, Emma C., Hurtado-Guerrero, Ramón, Malaker, Stacy A., Schumann, Benjamin“…We provide direct evidence that the glycosyltransferase GalNAc-T1 primes glycosylation at Thr678 in the living cell, an event that is suppressed by mutations in the VOCs Alpha, Delta, and Omicron. …”
Publicado 2023
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3852por Feng, Yifan, Wang, Jianbin, Zhang, Jian, Qi, Xuming, Long, Wenxing, Ding, Yi, Liu, Lan“…We test this hypothesis for soil bacteria and fungi along a 265–1,400 m elevational gradient on Hainan Island of tropical China, representing diverse vegetation types from deciduous monsoon forest to cloud forest. …”
Publicado 2023
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3853por Lozano-Mendoza, Janeth, Ramírez-Montiel, Fátima, Rangel-Serrano, Ángeles, Páramo-Pérez, Itzel, Mendoza-Macías, Claudia Leticia, Saavedra-Salazar, Faridi, Franco, Bernardo, Vargas-Maya, Naurú, Jeelani, Ghulam, Saito-Nakano, Yumiko, Anaya-Velázquez, Fernando, Nozaki, Tomoyoshi, Padilla-Vaca, Felipe“…Entamoeba histolytica virulence results from complex host–parasite interactions implicating multiple amoebic components (e.g., Gal/GalNAc lectin, cysteine proteinases, and amoebapores) and host factors (microbiota and immune response). …”
Publicado 2023
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3854por Zhao, Biao, Bai, Zhongyi, Lv, Hualiang, Yan, Zhikai, Du, Yiqian, Guo, Xiaoqin, Zhang, Jincang, Wu, Limin, Deng, Jiushuai, Zhang, David Wei, Che, Renchao“…Herein, a conductive, stretchable, adaptable, self-healing, and biocompatible liquid metal GaInSn/Ni-based composite hydrogel is developed by incorporating a magnetic liquid metal into the hydrogel framework through crosslinking polyvinyl alcohol (PVA) with sodium tetraborate. …”
Publicado 2023
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3855“…Recently, Botryosphaeriales isolates were obtained from the dead twigs of Acacia mangium, Eucalyptus spp., Pinus massoniana, and Cunninghamia lanceolata in Guangdong, Guangxi, Hainan, and Fujian Provinces in southern China. This study aimed to understand the diversity, distribution, and virulence of these Pseudofusicoccum species on these trees. …”
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3856“…A reverse transcriptase PCR indicated that the dominant viruses of chieh-qua in Hainan are MYSV (66.67%) and CCYV (55.56%), followed by CuCV (27.41%), WSMoV (7.41%), cucumber mosaic virus (8.15%), zucchini yellow mosaic virus (6.67%), PRSV (6.67%) and CqEV (35.56%). …”
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3857por Liu, Qin, Xue, Tian-Tian, Zhang, Xiao-Xia, Yang, Xu-Dong, Qin, Fei, Zhang, Wen-Di, Wu, Lei, Bussmann, Rainer W., Yu, Sheng-Xiang“…Numerous hotspots in southwestern China (e.g., Sichuan, Yunnan, Guangxi, and Hainan) were identified as conservation gaps. Given that NT plants include large proportions of endemic and narrow-ranged species, they represent an important value in conservation priority. …”
Publicado 2023
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3858por Xu, Han, Xia, Lian, Spence, John R, Lin, Mingxian, Lu, Chunyang, Li, Yanpeng, Chen, Jie, Luo, Tushou, Li, Yide, Fang, Suqin“…Squirrels of temperate zones commonly store nuts or seeds under leaf litter, in hollow logs, or even in holes in the ground; however, in the humid rainforests of Jianfengling in Hainan, South China, we show that some flying squirrels cache elliptical or oblate nuts by hanging them securely in vegetation. …”
Publicado 2023
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3859por Yenilmez, Batuhan, Harney, Shauna, DiMarzio, Chloe, Kelly, Mark, Min, Kyounghee, Echeverria, Dimas, Bramato, Brianna M., Jackson, Samuel O., Reddig, Keith, Kim, Jason K., Khvorova, Anastasia, Czech, Michael P.“…Further, we employ a dual targeting approach to NASH that selectively depletes collagen through selective stellate cell knockout of FASN (using AAV9-LRAT Cre in FASN(fl/fl) mice), while lowering hepatocyte triglyceride by depleting DGAT2 with a GalNac-conjugated, fully chemically modified siRNA. …”
Publicado 2023
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3860por Citraro, Rita, Bosco, Francesca, Di Gennaro, Gianfranco, Tallarico, Martina, Guarnieri, Lorenza, Gallelli, Luca, Rania, Vincenzo, Siniscalchi, Antonio, De Sarro, Giovambattista, Leo, Antonio“…Methods: In the present study, we evaluated the effects of Riluzole (RLZ) against limbic seizures, induced by AMPA, kainate, and NMDA receptor agonists in Sprague–Dawley rats, and in a well-validated genetic model of absence epilepsy, the WAG/Rij rat. …”
Publicado 2023
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