“…To explore the genetic diversity of the sugarcane-infecting badnavirus complex in China, we tested 392 sugarcane leaf samples collected from Fujian, Yunnan, and Hainan provinces for the occurrence of SCBV by polymerase chain reaction (PCR) assays using published primers SCBV-F and SCBV-R that target the reverse transcriptase/ribonuclease H (RT/RNase H) regions of the viral genome. …”
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“…Moreover, NU6027 is neuroprotective in kainate-treated epileptic rats. Our results demonstrate that TRPC5 is a novel therapeutic target against oxidative neuronal injury in prolonged seizures and that NU6027 is a potent inhibitor of TRPC5. …”
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“…Furthermore, exoPB4SF is a strict exolytic sulfatase that only releases the sulfate group from the GalNAc residue located at the reducing end, whereas endoVB4SF preferentially removed sulfate esters from the reducing end toward the non-reducing end though its directional degradation property was not strict. …”
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“…We found that VEGF quickly inhibited the glutamate/hypoxia‐induced calcium influx, which was blocked by an AMPA receptor antagonist CNQX, but not D‐AP5 or UBP310, NMDA and kainate receptor antagonist, respectively. VEGF increased phosphorylation of PKCα and AMPA receptor subunit GluA2 in astrocytes, and these effects were diminished by SU1498 or calphostin C, a PKC inhibitor. …”
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“…SETTING: 29 provinces/cities/autonomous regions in mainland China, excluding Tibet and Hainan province. PARTICIPANTS: 3522 respondents in a condition in the previous 2 weeks or during the last 12 months were analysed. …”
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“…A total of 18 family members (nine affected patients and nine normal subjects) from Hainan, China, were recruited to the present study in December 2017. …”
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“…Ten billion EVs labeled with PKH26 were dispensed unilaterally into the left nostril of naïve rats, and rats that experienced two hours of kainate-induced SE. Six hours later, PKH26 + EVs were quantified from multiple forebrain regions using serial brain sections processed for different neural cell markers and confocal microscopy. …”
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“…After subjected to this long-term cold stress, the overwinter survival rate of ratoon ‘Chaling’ CWR was 100%, equals to that of ratoon ‘Dongxiang’ CWR which is northernmost distribution in the word among wild rice populations, higher than those of ratoon ‘Fusui’ CWR, ratoon ‘Jiangyong’ CWR, and ratoon ‘Liujiang’ CWR (63.55–83.5%) as well as those of ratoon ‘Hainan’ CWR, ratoon ‘Hepu’ CWR, and all the ratoon cultivated rice phenotypes including 3 japonica ones, 3 javanica ones, and 5 indica ones (0.0%). …”
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“…RESULTS: In the current study, BW, average daily gain, and gain:feed ratio showed significant improvement as dietary Zn-ASP increased (p<0.05) in growing pigs. …”
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“…Increasing dietary inclusion of hay had no influence (P ≥ 0.11) on final BW, ADG, gain:feed or observed/expected dietary NE(M) and NE(G), observed/expected dry matter intake (DMI), or observed/expected ADG. …”
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“…The presence of sub-terminal N-acetylgalactosamine (GalNAc)/Galactose (Gal) residues with terminal sialic acids on the bronchioloalveolar cell surfaces was confirmed using lung ultra-thin sections of adult and 0-day-old animals. …”
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“…The population attributable fractions ranged from 15.56% (95% CI: 9.12–21.82%) in Tibet to 35.09% (95% CI: 25.68–45.83%) in Guizhou among men, and from 0.28% (95% CI: 0.00–0.64%) in Hainan to 10.44% (95% CI: 4.86–16.32%) in Jilin among women. …”
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“…Using current self-reported weight as the anchor, participants were classified as (1) stable weight, (2) weight losers, (3) weight gainers and (4) weight cyclers. Cardiometabolic markers included fasting lipids, insulin sensitivity and blood pressure. …”
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“…The 6-O sulfation of glycosaminoglycans is carried out by carbohydrate 6-O sulfotransferases (C6OSTs), previously named Gal/GalNAc/GlcNAc 6-O sulfotransferases. Here, for the first time, we present a detailed phylogenetic reconstruction, analysis of gene synteny conservation and propose an evolutionary scenario for the C6OST family in major vertebrate groups, including mammals, birds, nonavian reptiles, amphibians, lobe-finned fishes, ray-finned fishes, cartilaginous fishes, and jawless vertebrates. …”
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“…Patients with IgA nephropathy seem to produce anti-GalNAc antibodies against a particularly defective IgA1. …”
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“…METHODS: A total of 958 centenarians (mean age = 102.8 years; 81.8% females) recruited from 18 regions in Hainan, China, completed the PSQI scale. Cronbach’s alpha coefficient was used to measure the internal consistency. …”
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“…Yunnan, Guangxi, Sichuan, Xizang and Taiwan were important sources of new discoveries, with more than 3300 new taxa and records from these five provinces. By area, Taiwan and Hainan, two islands in southern China, have the highest density of newly discovered species. …”
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“…While the angiotensin converting enzyme 2 (ACE2) protein is defined as the primary severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor, the viral serine molecule might be mobilized by the host's transmembrane protease serine subtype 2 (TMPRSS2) enzyme from the viral spike (S) protein and hijack the host’s N-acetyl-D-galactosamine (GalNAc) metabolism. The resulting hybrid, serologically A-like/Tn (T nouvelle) structure potentially acts as a host–pathogen functional molecular bridge. …”
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“…Ricin toxin’s B subunit (RTB) is a multifunctional galactose (Gal)-/N-acetylgalactosamine (GalNac)-specific lectin that promotes uptake and intracellular trafficking of ricin’s ribosome-inactivating subunit (RTA) into mammalian cells. …”
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“…(iii) In terms of centrality, the high-ranking provinces (or municipalities) were Beijing, Shanghai, Jiangsu, Zhejiang, Guangdong, Shandong, Hunan, Hubei, Fujian, Anhui, Jiangxi, and Tianjin, while the low-ranking were Tibet, Qinghai, Gansu, Ningxia, Inner Mongolia, Heilongjiang, Yunnan, Guizhou, Xinjiang, Hainan, Shaanxi, and Shanxi. (iv) Block 1 (eight provinces or municipalities), including Beijing, Tianjin, and Hebei, had a “net spillover” effect in the spatial network of health resource agglomeration capacities; Block 2, (seven provinces or municipalities), including Shanghai, Jiangsu, and Zhejiang, had a “bidirectional spillover” effect in the spatial network; Block 3 (seven provinces or municipalities), including Anhui, Hubei, and Hunan, had a “mediator” effect in the network; and Block 4, (nine provinces or municipalities), including Sichuan, Guizhou, and Tibet, had a “net beneficial” effect in the network. …”
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