“…Our results showed that R. e. siamensis exhibits two divergent mtDNA lineages (mainland and Hainan Island), which diverged around 0.2 Mya (95% HPD 0.1–0.2), possibly driven by the fluctuating sea levels of the Early Holocene period. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Cancer stem cells (CSC) have gained much attention and are now believed to play a crucial role in the pathogenesis of various cancers, including CRC. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A total of 1,609 children and adolescents from urban and rural areas in Hainan Province, South China, were selected using multi-stage stratified cluster sampling method. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We examined the distribution patterns of glutamatergic (AMPA, kainate, mGlu(2/3), and NMDA), GABAergic (GABA(A), GABA(A(BZ)), and GABA(B)), dopaminergic (D(1/5)) and noradrenergic (α(1) and α(2)) neurotransmitter receptors by quantitative in vitro receptor autoradiography combined with an analysis of the cyto- and myelo-architecture. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We observed responses to glutamate in the low µM range. MCC responded to kainate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and a subpopulation of 50% had functional NMDA-R. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this context, the main goal of this work was to develop a new nanosystem, composed of a polymeric core coated by a lipid bilayer containing the targeting ligand GalNAc, to specifically and efficiently co-deliver both drugs into HCC cells, in order to significantly increase their therapeutic efficacy. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: 60 LC patients treated in the First Affiliated Hospital of Gannan Medical University (January 2018–May 2021) were chosen as the research objects, and split into group J without nutritional risk and group Q with nutritional risk according to the results of NRS2002 to compare the preoperative situation, surgery-related indexes, hematological indexes, postoperative recovery, and incidence of complications between the two groups. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this study, samples were collected from the Java Sea coasts, from the South China Sea in Hainan Island coasts and Quảng Yên region and Rú Chá mangrove near Hue in Central Vietnam. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Purposive sampling and snowball sampling were employed to recruit 13 full-time working mothers with a stable job in the public sector who continued to breastfeed for 1 month or longer after returning to work in Haikou, Hainan Province, China. Interviews were conducted from January to March 2020 to capture participants’ experiences of breastfeed after returning to work. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We demonstrated that silencing C1GALT1 in CCA cell lines was associated with immature core 1 O-glycosylation, demonstrated by high expression of VVL-binding glycans and down-regulation of other main O-linked glycosyltransferases β1,3-N-acetylglucosaminyltransferase 6 (B3GNT6) and ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 1 (ST6GALNAC1) in C1GALT1 knockdown. Our findings demonstrate that down-regulation of C1GALT1 in CCA increases the expression of immature core 1 O-glycan, enhancing CCA progression, including growth and 5-fluorouracil resistance via the activation of the AKT/ERK signaling pathway.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Transcriptome and survival analyses revealed four potential tumor suppressor genes including KCNIP4, CACNA1C, PACRG, and ST6GALNAC3. In this study, we firstly proposed to combine 5mC and 6mA methylation sites to explore functional genes, and further research found top of these unstable methylation genes might be functional and some of them could serve as potential tumor suppressor genes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Coastal currents from north of SCS invade Beibu Gulf through Qiongzhou Strait and south of Hainan Island, as recorded by higher percentages of Paralia sulcata and Cyclotella striata at these sites. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our previous study showed that a total of 144 endophytic actinomycetes were isolated from different tissues of medicinal plants in Hainan, China. Especially, strain 8ZJF-21 exhibited a broad-spectrum antifungal activity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Using CRISPR/Cas9 gene editing, we introduced a gain-of-function variant into the endogenous mouse Kcnt1 gene. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: The prospective cohort study enrolled 30 active SLE patients (SG1 group), 30 stable SLE patients (SG2 group), and 20 healthy individuals (RG group) in the First Affiliated Hospital of Hainan Medical University between January 2018 and June 2020. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: Data from 1226 women were obtained from the China Hainan Centenarian Cohort Study. Home interviews, physical examinations and blood analyses were conducted using standardized procedures. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: The routine blood test (RBT) results of 617 healthy men aged 18–45 years old of the Li, Tibet, and Han nationalities living in the city of Sanya, Hainan Province (200 m), the city of Xining, Qinghai Province (2,300 m), and Maduo County of Qinghai Province (4,300 m) for a long time were studied. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The most likely cluster appeared in the southern coastal provinces (Guangxi, Guangdong, Hainan) from 2011 to 2017 and in the eastern coastal provinces (Shanghai, Jiangsu, Zhejiang) in 2018. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Analyses of the transcriptome data from four different fish species (Hainan medaka (Oryzias curvinotus), silver sillago (Sillago sihama), Nile tilapia (Oreochromis niloticus), and Hong Kong catfish (Clarias fuscus)) revealed ovaries biased expression of 42Sp50 in all, similar to spotted scat. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Stemona parviflora is an endangered species, narrowly endemic to Hainan and Southwest Guangdong. The taxonomic classification of S. parviflora remains controversial. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso