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701por Englund, Jonas, Haikonen, Joni, Shteinikov, Vasilii, Amarilla, Shyrley Paola, Atanasova, Tsvetomira, Shintyapina, Alexandra, Ryazantseva, Maria, Partanen, Juha, Voikar, Vootele, Lauri, Sari E.“…Here we identify a novel mechanism by which kainate receptors (KARs) modulate feedforward inhibition in the lateral amygdala (LA) and show that this mechanism is downregulated after ELS induced by maternal separation (MS). …”
Publicado 2021
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702por Schlegel, Mark K, Matsuda, Shigeo, Brown, Christopher R, Harp, Joel M, Barry, Joseph D, Berman, Daniel, Castoreno, Adam, Schofield, Sally, Szeto, John, Manoharan, Muthiah, Charissé, Klaus, Egli, Martin, Maier, Martin A“…We recently reported that RNAi-mediated off-target effects are important drivers of the hepatotoxicity observed for a subset of GalNAc–siRNA conjugates in rodents, and that these findings could be mitigated by seed-pairing destabilization using a single GNA nucleotide placed within the seed region of the guide strand. …”
Publicado 2021
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703“…Chemical investigation of the Hainan soft coral Sinularia hirta resulted in the isolation and identification of a library of sixteen structurally diverse terpenoids, including a dinorditerpenoid with an uncommon 17,19-dinorxeniaphyllane skeleton, namely sinuhirtone A (7), six new xeniaphyllane-type diterpenoids (1–6), one new norxeniaphyllanoid (8), two new norcaryophyllene-type sesquiterpenoids (9 and 10), together with six known related compounds (11–16). …”
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704por Lu, Jiamiao, Swearingen, Elissa, Hardy, Miki, Collins, Patrick, Wu, Bin, Yuan, Eric, Lu, Daniel, Li, Chi-Ming, Wang, Songli, Ollmann, Michael“…Delivery of siRNA therapeutics to the liver has been established, with conjugation of siRNA to N-acetylgalactosamine (GalNAc) providing durable gene knockdown in hepatocytes following subcutaneous injection. …”
Publicado 2022
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705por Shi, Huanhuan, Zeng, Min, Peng, Hongxia, Huang, Changsheng, Sun, Huimin, Hou, Qingqin, Pi, Pengcheng“…This study emphasizes the importance of quantitative evaluation of the HM pollution sources and probabilistic health risk assessment, which provides an essential basis for water pollution prevention and control in Hainan Island.…”
Publicado 2022
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706“…Saunders 2012 is produced in Hainan province. The trunk is straight, the wood texture is straight, and the material is slightly soft, which is suitable for furniture and building materials. …”
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708por Nielsen, Mathias I., de Haan, Noortje, Kightlinger, Weston, Ye, Zilu, Dabelsteen, Sally, Li, Minyan, Jewett, Michael C., Bagdonaite, Ieva, Vakhrushev, Sergey Y., Wandall, Hans H.“…We find over 300 unique glycosylation sites across a diverse set of proteins specifically regulated by one of the GalNAc-T isoforms, consistent with their impact on the tissue phenotypes. …”
Publicado 2022
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709por Huang, Jianmei, Li, Meiying, Mei, Bingjie, Li, Junyang, Zhu, Yi, Guo, Qiaoshan, Huang, Jianming, Zhang, Guonan“…BACKGROUND: Aberrant sialoglycans on the surface of tumor cells shield potential tumor antigen epitopes, escape recognition, and suppress activation of immunocytes. α2,3/α2,6Gal- and α2,6GalNAc (Gal/GalNAc)-linked sialic acid residues of sialoglycans could affect macrophage galactose-type lectins (MGL) mediated-antigen uptake and presentation and promote sialic acid-binding immunoglobulin-like lectins (Siglecs) mediated-immunosuppression. …”
Publicado 2022
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710por Chatterjee, Mahasweta, Saha, Sharmistha, Dutta, Nilanjana, Sinha, Swagata, Mukhopadhyay, Kanchan“…Owing to a higher expression of the glutamate ionotropic receptor kainate type subunit 1 (GluK1), encoded by the GRIK1 gene, in brain regions responsible for learning and memory, we hypothesized that GRIK1 might have a role in ADHD. …”
Publicado 2022
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711por Sun, Ying, Li, Yuanyuan, Xu, Yu, Sang, Yali, Mei, Siyi, Xu, Chaobin, Yu, Xingguo, Pan, Taoyu, Cheng, Chen, Zhang, Jun, Jiang, Yueming, Gao, Zhiqiang“…Gannan navel orange (Citrus sinensis Osbeck cv. Newhall) is an economically important fruit, but postharvest loss occurs easily during storage. …”
Publicado 2022
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712“…Three new species of the predaceous midges of genus Alluaudomyia Kieffer, 1913: A.flavinotum Wu & Li, sp. nov. of the maculipennis group, and A.reflexuralis Wu & Li, sp. nov. and A.limu Wu & Li, sp. nov. of the parva group, are described from the National Park of Hainan Tropical Rainforest, Hainan Island, China. …”
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