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5761por Liaw, Janie, Hong, Geunhye, Davies, Cadi, Elmi, Abdi, Sima, Filip, Stratakos, Alexandros, Stef, Lavinia, Pet, Ioan, Hachani, Abderrahman, Corcionivoschi, Nicolae, Wren, Brendan W., Gundogdu, Ozan, Dorrell, Nick“…The role of the T6SS in interactions with host cells is explored using in vitro and in vivo models, and the presence of the T6SS is shown to increase C. jejuni cytotoxicity in the Galleria mellonella infection model. In biologically relevant models, the T6SS enhances C. jejuni interactions with and invasion of chicken primary intestinal cells and enhances the ability of C. jejuni to colonize chickens. …”
Publicado 2019
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5762por Zhao, Xueru, Feng, Weijia, Zhu, Xiangyang, Li, Chenxi, Ma, Xiaoyu, Li, Xin, Zhu, Xudong, Wei, Dongsheng“…Approximately half of the atgΔ strains displayed higher sensitivity to 1.5 M NaCl and remarkably lower virulence in the Galleria mellonella model than the wild type. Autophagic flux in C. neoformans was dependent on the Atg1-Atg13, Atg5-Atg12-Atg16, and Atg2-Atg18 complexes and Atg11. …”
Publicado 2019
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5763por Williams, Caitlin L., Neu, Heather M., Alamneh, Yonas A., Reddinger, Ryan M., Jacobs, Anna C., Singh, Shweta, Abu-Taleb, Rania, Michel, Sarah L. J., Zurawski, Daniel V., Merrell, D. Scott“…Given the crucial antimicrobial role of copper-mediated killing employed by the immune system, virulence of these mutant strains was investigated in Galleria mellonella; many of the mutant strains were attenuated. …”
Publicado 2020
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5764por Jitprasutwit, Siroj, Jitprasutwit, Niramol, Hemsley, Claudia M., Onlamoon, Nattawat, Withatanung, Patoo, Muangsombut, Veerachat, Vattanaviboon, Paiboon, Stevens, Joanne M., Ong, Catherine, Stevens, Mark P., Titball, Richard W., Korbsrisate, Sunee“…Deletion mutants of two macrophage-induced genes from this study were attenuated in Galleria mellonella larvae, suggesting roles in virulence. …”
Publicado 2020
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5765por Kirchhoff, Lisa, Weisner, Ann-Kathrin, Schrepffer, Mona, Hain, Andrea, Scharmann, Ulrike, Buer, Jan, Rath, Peter-Michael, Steinmann, Joerg“…Experiments testing the virulence of E. dermatitidis in the greater wax moth Galleria mellonella showed a synergetic effect on larval killing when E. dermatitidis was injected together with P. aeruginosa culture filtrate. …”
Publicado 2020
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5766“…METHODS: Clinical, microbiological and outcome data were collected by medical record review of patients discharged from Ballarat Hospital with a diagnosis of CAP over a 12 month period. …”
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5767por Kong, Qinxiang, Cao, Zubai, Lv, Na, Zhang, Hui, Liu, Yanyan, Hu, Lifen, Li, Jiabin“…Compared with FLU alone, the combination of MINO with FLU prolonged the survival rate of Galleria mellonella larvae infected with FLU-resistant C. neoformans, and also significantly decreased the fungal burden of infected larvae and reduced the tissue damage and destruction caused by FLU-resistant C. neoformans. …”
Publicado 2020
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5768“…Finally, by using a Galleria mellonella infection model, we show that H3-T6SS plays a key role in the pathogenicity of P. aeruginosa in vivo. …”
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5769por Yero, Daniel, Huedo, Pol, Conchillo-Solé, Oscar, Martínez-Servat, Sònia, Mamat, Uwe, Coves, Xavier, Llanas, Ferran, Roca, Ignasi, Vila, Jordi, Schaible, Ulrich E., Daura, Xavier, Gibert, Isidre“…Strains of variant rpf-2 were also significantly more virulent to Galleria mellonella larvae than those of rpf-1, most likely due to an increased ability of rpf-2 strains to form biofilms. …”
Publicado 2020
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5770por Ito, Yuya, Miyazaki, Taiga, Tanaka, Yutaka, Suematsu, Takashi, Nakayama, Hironobu, Morita, Akihiro, Hirayama, Tatsuro, Tashiro, Masato, Takazono, Takahiro, Saijo, Tomomi, Shimamura, Shintaro, Yamamoto, Kazuko, Imamura, Yoshifumi, Izumikawa, Koichi, Yanagihara, Katsunori, Kohno, Shigeru, Mukae, Hiroshi“…Although the elm1Δ strain exhibited slower growth than the other two strains, as well as increased sensitivity to high temperature and cell-wall-damaging agents, it showed increased virulence in a Galleria mellonella-infection model. Moreover, loss of Elm1 resulted in increased adhesion to agar plates and epithelial cells, which represent important virulence factors in C. glabrata. …”
Publicado 2020
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5771por Moman, Raja, O’Neill, Catherine A., Ledder, Ruth G., Cheesapcharoen, Tanaporn, McBain, Andrew J.“…The larvae of the wax moth Galleria mellonella and human oral keratinocytes were used to investigate the protective activity of the candidate oral probiotics Lactobacillus rhamnosus GG (LHR), Lactobacillus reuteri (LR), and Streptococcus salivarius K-12 (SS) against the periodontal pathogens Fusobacterium nucleatum (FN), Porphyromonas gingivalis (PG), and Aggregatibacter actinomycetemcomitans (AA). …”
Publicado 2020
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5772por Shen, Ping, Berglund, Björn, Chen, Yong, Zhou, Yanzi, Xiao, Tingting, Xiao, Yonghong, Zhou, Kai“…Discrepancies among measured virulence in Galleria mellonella and the serum-killing assay, and genotypes and phenotypes were detected. …”
Publicado 2020
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5773por Khan, Noor, Martínez-Hidalgo, Pilar, Humm, Ethan A., Maymon, Maskit, Kaplan, Drora, Hirsch, Ann M.“…In addition, to ensure the biosafety of this previously unknown plant growth promoting bacterial (PGPB) strain as a potential bioinoculant, we tested the survival and growth of Caenorhabditis elegans and Galleria mellonella (two animal virulence tests) as well as plants in response to D. cinnamea 55 inoculation. …”
Publicado 2020
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5774por Guérin, François, Lallement, Claire, Goudergues, Benoit, Isnard, Christophe, Sanguinetti, Maurizio, Cacaci, Margherita, Torelli, Riccardo, Cattoir, Vincent, Giard, Jean-Christophe“…To this end, a high-density random transposon insertion library was obtained from E. cloacae subsp. cloacae ATCC 13047, which was used to analyze the fitness of ca. 300,000 mutants in Galleria mellonella colonization model. Following massively parallel sequencing, we identified 624 genes that seemed essential for the optimal growth and/or the fitness within the host. …”
Publicado 2020
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5775por Gato, Eva, Vázquez-Ucha, Juan Carlos, Rumbo-Feal, Soraya, Álvarez-Fraga, Laura, Vallejo, Juan A., Martínez-Guitián, Marta, Beceiro, Alejandro, Ramos Vivas, Jose, Sola Campoy, Pedro J., Pérez-Vázquez, María, Oteo Iglesias, Jesus, Rodiño-Janeiro, Bruno Kotska, Romero, Antonio, Poza, Margarita, Bou, Germán, Pérez, Astrid“…Moreover, the in vivo intestinal colonizing capacity of the Kpi-defective mutant was significantly reduced, as was its ability to infect Galleria mellonella. The findings provide information about the pathobiology and epidemicity of Kpi(+) K. pneumoniae and indicate that the presence of Kpi may explain the success of the ST-15 clone. …”
Publicado 2020
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5776por Mageeney, Catherine M., Sinha, Anupama, Mosesso, Richard A., Medlin, Douglas L., Lau, Britney Y., Rokes, Alecia B., Lane, Todd W., Branda, Steven S., Williams, Kelly P.“…The Δint phages, individually and in cocktails, killed P. aeruginosa PAO1 in liquid culture as well as in a waxworm (Galleria mellonella) model of infection. IMPORTANCE The antibiotic resistance crisis has led to renewed interest in phage therapy as an alternative means of treating infection. …”
Publicado 2020
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5777por Seribelli, Amanda Aparecida, Cruz, Marcelo Ferreira, Vilela, Felipe Pinheiro, Frazão, Miliane Rodrigues, Paziani, Mario H., Almeida, Fernanda, Medeiros, Marta Inês Cazentini, Rodrigues, Dália dos Prazeres, Kress, Marcia R. von Zeska, Allard, Marc W., Falcão, Juliana Pfrimer“…Their virulence potential was determined using the Galleria mellonella larvae model combined with the analysis of virulence genes by whole genome sequencing (WGS). …”
Publicado 2020
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5778por Zou, Jin, Kou, Si-Hoi, Xie, Ruiqiang, VanNieuwenhze, Michael S., Qu, Jiuxin, Peng, Bo, Zheng, Jun“…Importantly, these non-walled spherical bacteria also persisted during antibiotic therapy in vivo using Galleria mellonella as the infection model. Additionally, the combinational treatment on A. baumannii by β-lactam and membrane-targeting antibiotic significantly enhanced the killing efficacy. …”
Publicado 2020
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5779Optimising efficacy of antibiotics against systemic infection by varying dosage quantities and timespor Hoyle, Andy, Cairns, David, Paterson, Iona, McMillan, Stuart, Ochoa, Gabriela, Desbois, Andrew P.“…Here, we aimed to address these limitations by using experiments in a Galleria mellonella (insect) model of bacterial infection to create a fully parametrised mathematical model of a systemic Vibrio infection. …”
Publicado 2020
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5780por Schäfer, Walter, Schmidt, Teresa, Cordsmeier, Arne, Borges, Vítor, Beare, Paul A., Pechstein, Julian, Schulze-Luehrmann, Jan, Holzinger, Jonas, Wagner, Nicole, Berens, Christian, Heydel, Carsten, Gomes, João Paulo, Lührmann, Anja“…Importantly, only the full-length protein from the first group is a bona fide effector protein injected into host cells during infection and has anti-apoptotic activity. Finally, using the Galleria mellonella infection model, we observed that AnkG from the first group has the ability to attenuate pathology during in vivo infection, as it allows survival of the larvae despite bacterial replication.…”
Publicado 2020
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