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592“…In addition, phage BUCT631 could quickly inhibit the growth of K. pneumoniae within 2 h in vitro and significantly elevated the survival rate of K. pneumoniae infected Galleria mellonella larvae from 10% to 90% in vivo. …”
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593por Samdavid Thanapaul, Rex Jeya Rajkumar, Roberds, Ashleigh, Rios, Kariana E., Walsh, Thomas J., Bobrov, Alexander G.“…However, in clinical cases of wound mucormycosis caused by traumatic inoculation, hyphal elements found in soil are likely the form of the inoculated organism. In this study, Galleria mellonella larvae were infected with either sporangiospores or hyphae of Rhizopus arrhizus and Lichtheimia corymbifera. …”
Publicado 2023
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594por Mukherjee, Krishnendu, Hain, Torsten, Fischer, Rainer, Chakraborty, Trinad, Vilcinskas, Andreas“…We recently established the larvae of the greater wax moth (Galleria mellonella) as a model host for the investigation of L. monocytogenes pathogenesis and as a source of peptides exhibiting anti-Listeria-activity. …”
Publicado 2013
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595“…Survival to starvation and iron limitation was comparable for the mucoid parental isolate and the respective nonmucoid variant, while susceptibility to antibiotics and to oxidative stress was increased in the nonmucoid variants. Acute infection of Galleria mellonella larvae showed that, in general, the nonmucoid variants were less virulent than the respective parental mucoid isolate, suggesting a role for the exopolysaccharide in virulence. …”
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596por Aparecida Procópio Gomes, Livia, Alves Figueiredo, Lívia Mara, Luiza do Rosário Palma, Ana, Corrêa Geraldo, Barbara Maria, Isler Castro, Kelly Cristine, Ruano de Oliveira Fugisaki, Luciana, Olavo Cardoso Jorge, Antônio, Dias de Oliveira, Luciane, Campos Junqueira, Juliana“…The aim was to evaluate the antimicrobial activity of pomegranate glycolic extract (PGE) against the periodontal pathogen Porphyromonas gingivalis by using Galleria mellonella as in vivo model. Fifteen larvae were used per group. …”
Publicado 2016
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597“…Furthermore, the cytotoxicity of the recombinant protein against the haemocytes of Galleria mellonella larvae was investigated. We found that the protein had haemocoel insecticidal activity against G. mellonella with an LD50 of 131.5 ng/larva. …”
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598“…Larvae of the insect Galleria mellonella are increasingly being used for studying pathogenic microbes and their virulence mechanisms, and as a rapid model for screening novel antimicrobial agents. …”
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599por Lu, Mengjiao, Yang, Xinmei, Yu, Cuixiang, Gong, Ying, Yuan, Lei, Hao, Lina, Sun, Shujuan“…In vivo, linezolid plus azoles prolonged the survival rate of infected Galleria mellonella larvae twofold compared with the azole monotherapy group, significantly decreased the fungal burden of the infected larvae, and reduced the damage of resistant C. albicans to the larval tissue. …”
Publicado 2019
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600por Cools, Freya, Torfs, Eveline, Aizawa, Juliana, Vanhoutte, Bieke, Maes, Louis, Caljon, Guy, Delputte, Peter, Cappoen, Davie, Cos, Paul“…To lower the time and costs of the drug discovery process, alternative in vivo models should be considered. As such, Galleria mellonella larvae can be of great value. The larval immunity consisting of several types of haemocytes is remarkably similar to the human innate immune system. …”
Publicado 2019
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