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  1. 7641
    “…BACKGROUND: Green tea polyphenol epigallocatechin-3-gallate (EGCG) has been demonstrated to inhibit cancer in experimental studies through its antioxidant activity and modulations on cellular functions by binding specific proteins. …”
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    The up-regulation of Myb may help mediate EGCG inhibition effect on mouse lung adenocarcinoma
  2. 7642
    “…The bioavailability, tissue distribution and metabolic fate of the major tea polyphenols, catechins and theaflavins as well as their gallated derivatives are yet to be precisely elucidated on a single identification platform for assessment of their relative bioefficacy in vivo. …”
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    Simultaneous Determination of Black Tea-Derived Catechins and Theaflavins in Tissues of Tea Consuming Animals Using Ultra-Performance Liquid-Chromatography Tandem Mass Spectrometry
  3. 7643
    “…In this study, a novel semisynthetic flavonoid 7-O-galloylquercetin (or quercetin-7-gallate, 3) was prepared by direct galloylation of quercetin, and its effect on the Nrf2 pathway was examined. …”
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    Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells
  4. 7644
    “…MATERIALS AND METHODS: In this in-vitro study, 90 human enamel surfaces were randomly divided into six groups as follows (n=15): G1, no bleaching; G2, bleaching with 40% hydrogen peroxide (HP); G3, HP+1000 μmol epigallocatechin gallate (EGCG) for 10 minutes; G4, HP+10% sodium ascorbate for 10 minutes; G5, HP+10% sage for 10 minutes and G6, HP+5% grape seed extract for 10 minutes. …”
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    In-Vitro Evaluation of the Effect of Herbal Antioxidants on Shear Bond Strength of Composite Resin to Bleached Enamel
  5. 7645
    “…Treatment with Dyrk1A inhibitor, green tea flavonol epigallocatechin-gallate (EGCG), from gestation to adulthood suppressed 3R-tau expression and rescued anxiety and memory deficits in Ts65Dn mouse brains. …”
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    Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice
  6. 7646
    “…RESULTS: Hexane and chloroform fractions exhibited the highest antioxidant activity with IC(50) values of (0.098 ± 0.08 and 0.099 ± 0.029 mg/ml) respectively. Standard propyl gallate had the lowest IC(50) value of 0.0414 ± 0.11 mg/ml. …”
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    Antioxidant activity, acetylcholinesterase inhibitory potential and phytochemical analysis of Sarcocephalus latifolius Sm. bark used in traditional medicine in Sudan
  7. 7647
    “…To this end, a PBPK model of epigallocatechin gallate (EGCg) consisting of 13 first‐order, blood flow‐limited tissue compartments was first developed in rats. …”
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    Physiologically based pharmacokinetic modeling of tea catechin mixture in rats and humans
  8. 7648
    “…V RESULTS: The ADIs of total catechins and epigallocatechin gallate (EGCg) were 110 and 21.4 mg/day in men and 157 and 34.7 mg/day in women, respectively. …”
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    Actual Daily Intakes of Tea Catechins and Thier Estimation According to Four Season 3 Day Weighed Dietary Records and a Short Food Frequency Questionnaire among Japanese Men and Women
  9. 7649
    “…OBJECTIVE: To observe the protective effect of epigallocatechin gallate (EGCG) on dextran sulfate sodium- (DSS-) induced ulcerative colitis in rats and to explore the roles of TLR4/MyD88/NF-κB signaling pathway. …”
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    EGCG Maintains Th1/Th2 Balance and Mitigates Ulcerative Colitis Induced by Dextran Sulfate Sodium through TLR4/MyD88/NF-κB Signaling Pathway in Rats
  10. 7650
    “…To learn more about the pharmacokinetics and interindividual variation of green tea polyphenols after oral intake in humans we performed a population nutrikinetic study of standardized green tea extract. 84 healthy participants took green tea extract capsules standardized to 150 mg epigallocatechin-gallate (EGCG) twice a day for 5 days. On day 5 catechin plasma concentrations were analyzed using non-compartmental and population pharmacokinetic methods. …”
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    Population nutrikinetics of green tea extract
  11. 7651
    “…Cancer preventive activities of green tea and its main constituent, (−)-epigallocatechin gallate (EGCG) have been extensively studied by scientists all over the world. …”
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    Cancer Prevention with Green Tea and Its Principal Constituent, EGCG: from Early Investigations to Current Focus on Human Cancer Stem Cells
  12. 7652
    “…In contrast, epigallocatechin gallate and magnetic force synergistically enhanced PLL-MNP uptake. …”
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    Interaction of poly-l-lysine coating and heparan sulfate proteoglycan on magnetic nanoparticle uptake by tumor cells
  13. 7653
    “…For 12 weeks, the placebo group received barley extract without catechin; another group received “Sunrouge” extract containing 11.2 mg anthocyanin and 323.6 mg epigallocatechin-3-O-gallate (EGCG); and a third group received “Yabukita” extract containing 322.2 mg EGCG. …”
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    A Randomized, Placebo-Controlled Study on the Safety and Efficacy of Daily Ingestion of Green Tea (Camellia sinensis L.) cv. “Yabukita” and “Sunrouge” on Eyestrain and Blood Pressure in Healthy Adults
  14. 7654
    “…Specifically, we demonstrate the ability of curcumin (Cur) and epigallocatechin-3-gallate (EGCG) to independently act as reducing agents to produce phytochemical-capped AgNPs that show biologically desirable interactions with HSA. …”
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    Phytochemicals as Dynamic Surface Ligands To Control Nanoparticle–Protein Interactions
  15. 7655
    “…Insertion of more reductive phenolic moiety such as catechuate and gallate lead to more lipoxygenase inhibition potency of the esters as observed in their radical scavenging activity.…”
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    Design and synthesis of new esters of terpenoid alcohols as 15-lipoxygenase inhibitors
  16. 7656
    “…Hence, the present study aimed to evaluate the neuroprotective role of epigallocatechin-gallate (EGCG) loaded nanoparticles (nanoEGCG) against aluminum chloride (AlCl(3)) induced neurobehavioral and pathological changes in AD induced rats. …”
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    EGCG Nanoparticles Attenuate Aluminum Chloride Induced Neurobehavioral Deficits, Beta Amyloid and Tau Pathology in a Rat Model of Alzheimer’s Disease
  17. 7657
    “…A number of laboratory experiments demonstrated the benefits of green tea and green tea catechins (GTCs), such as epigallocatechin gallate (EGCG), and proposed action mechanisms. The targets of GTCs include the abnormal accumulation of fibrous proteins, such as Aβ and α-synuclein, inflammation, elevated expression of pro-apoptotic proteins, and oxidative stress, which are associated with neuronal cell dysfunction and death in the cerebral cortex. …”
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    Beneficial Effects of Green Tea Catechins on Neurodegenerative Diseases
  18. 7658
    “…Finally, several phenolic compounds in the extract were identified and quantified by UPLC-MS/MS, which were rutin, gallic acid, protocatechuic acid, epicatechin, epicatechin gallate, 2-hydrocinnamic acid, p-coumaric acid, quercetin, chlorogenic acid and ferulic acid.…”
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    Microwave-Assisted Extraction of Natural Antioxidants from the Exotic Gordonia axillaris Fruit: Optimization and Identification of Phenolic Compounds
  19. 7659
    “…Furthermore, 22 phenolics were first identified in ATL extract obtained under the optimized conditions, indicating that gallates, gallotannins, quercetin, myricetin and chlorogenic acid derivatives were the main phenolic components in ATL. …”
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    Response Surface Methodology Optimization of Ultrasonic-Assisted Extraction of Acer Truncatum Leaves for Maximal Phenolic Yield and Antioxidant Activity
  20. 7660
    “…Enzymatic assays revealed that the recombinant UGT73A17 protein (rUGT73A17) exhibited activity toward flavonols (kaempferol, quercetin, and myricetin), flavones (apigenin, luteolin, and tricetin), flavanone (naringenin), isoflavones (genistein) and epicatechin gallate, yielding 7-O-glucosides as the major in vitro products. …”
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    Characterization of a heat responsive UDP: Flavonoid glucosyltransferase gene in tea plant (Camellia sinensis)
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