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  1. 1
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    Novel Gemini ionic liquid for oxidative desulfurization of gas oil
  2. 2
    “…RESULTS: At week 96, dolutegravir + lamivudine (N = 716) was noninferior to dolutegravir + tenofovir disoproxil fumarate/emtricitabine (N = 717) in achieving HIV-1 RNA <50 copies/mL (Snapshot algorithm; −10% noninferiority margin) in the pooled analysis (proportion of responders, 86.0% vs 89.5%, respectively; adjusted treatment difference [95% CI], −3.4% [−6.7 to 0.0007]), GEMINI-1 (−4.9% [−9.8 to 0.03]), and GEMINI-2 (−1.8% [−6.4 to 2.7]). …”
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    Durable Efficacy of Dolutegravir Plus Lamivudine in Antiretroviral Treatment–Naive Adults With HIV-1 Infection: 96-Week Results From the GEMINI-1 and GEMINI-2 Randomized Clinical Trials
  3. 3
    “…However, Im3̅m cubosomes were obtained at solid ratios of DLGL/PHY of 6, 7.5, and 10% w/w. The lattice parameters of the Pn3̅m and Im3̅m cubosomes were approximately 7 and 11–13 nm, respectively. …”
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    Preparation of Cubosomes with Improved Colloidal and Structural Stability Using a Gemini Surfactant
  4. 4
    “…In this study, gemini ammonium sulfobetaine (GAS) is designed and synthesized using isophorone diisocyanate connecting the ammonium sulfobetaines (AS) to obtain a viscoelastic surfactant exhibiting better viscosification and salt resistance. …”
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    Synthesis of gemini ammonium sulfobetaine and its proppant suspension and gel-breaking mechanisms
  5. 5
    por Gospodarczyk, W., Kozak, M.
    Publicado 2015
    “…In this work, the influence of two selected dicationic (gemini) surfactants (3,3′-[1,8-(2,7-dioxaoctane)]bis(1-dodecylimidazolium) chloride and 3,3′-[1,12-(2,11-dioxadodecane)]bis(1-dodecylimidazolium) chloride) on two model proteins, bovine serum albumin (BSA) and hen egg white lysozyme (HEWL), have been investigated. …”
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    Interaction of two imidazolium gemini surfactants with two model proteins BSA and HEWL
  6. 6
    “…We evaluated the efficacy of vedolizumab, a gut-selective α(4)β(7) integrin antagonist approved for treating moderately to severely active CD, in a subpopulation of patients with fistulising CD who participated in the GEMINI 2 trial [NCT00783692]. …”
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    Efficacy of Vedolizumab in Fistulising Crohn’s Disease: Exploratory Analyses of Data from GEMINI 2
  7. 7
    “…This work reported the effect of cationic gemini surfactants, alkanediyl-α,ω-bis(dimethyldodecylammonium bromide) (C(12)C(S)C(12)Br(2), S = 2, 6, and 10) on the enzymatic activity and conformation of α-chymotrypsin (α-CT) in phosphate buffer solution (PBS, pH 7.3). …”
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    Controllable enzymatic superactivity of α-chymotrypsin activated by the electrostatic interaction with cationic gemini surfactants
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    “…Herein, we report the synthesis of four novel non-ionic Gemini amphiphiles using a chemo-enzymatic approach. …”
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    Fabrication of hydrolase responsive diglycerol based Gemini amphiphiles for dermal drug delivery applications
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    “…RESULTS: During the induction phase, in Asian countries (n = 51), 14.7% of the vedolizumab-treated patients achieved clinical remission at week 6 compared to none with placebo (difference, 14.7%; 95% confidence interval, 15.8%–43.5%). …”
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    Efficacy and safety of vedolizumab in Crohn’s disease in patients from Asian countries in the GEMINI 2 study
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    Physicochemical Evaluation of Micellar Solution and Lyotropic Phases Formed by Self-Assembled Aggregates of Morpholinium Geminis
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    “…However, Azone was found to be the most effective permeation enhancer for ketoprofen, attaining a total of 138.4 μg cm(−2) permeated, 2.7-fold over controls. This work demonstrates that gemini surfactants are effective in terms of increasing the permeation of drugs, especially in the case of hydrophilic ionized compounds, that do not easily cross the stratum corneum. …”
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    Structure Activity Relationships in Alkylammonium C(12)-Gemini Surfactants Used as Dermal Permeation Enhancers
  12. 12
    “…BACKGROUND/AIMS: The efficacy and safety of vedolizumab in moderate to severely active ulcerative colitis (UC) have been demonstrated in the GEMINI 1 study (NCT00783718). This post-hoc exploratory analysis sought to establish the efficacy and safety of vedolizumab in a subgroup of patients from Asian countries with UC from GEMINI 1. …”
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    Efficacy and safety of vedolizumab in ulcerative colitis in patients from Asian countries in the GEMINI 1 study
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    “…To explore the effect of spacer structure on the adsorption capability of organo-vermiculites (organo-Vts), a series of aza-containing gemini surfactants (5N, 7N and 8N) are applied to modify Na-vermiculite (Na-Vt). …”
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    Organo-Vermiculites Modified by Aza-Containing Gemini Surfactants: Efficient Uptake of 2-Naphthol and Bromophenol Blue
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    “…A total of 163 individuals were randomized to AGN-190584 and 160 were randomized to vehicle. GEMINI 1 met its primary and key secondary efficacy end points. …”
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    Safety and Efficacy of AGN-190584 in Individuals With Presbyopia: The GEMINI 1 Phase 3 Randomized Clinical Trial
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    “…Especially at 140 mM and pH 6.7, the mixture showed high viscoelasticity, and the maximum of the zero-shear viscosity reached 1530 Pa·s. …”
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    pH-Responsive Rheological Properties and Microstructure Transition in Mixture of Anionic Gemini/Cationic Monomeric Surfactants
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    “…In this study, a novel gemini surfactant (GLO) with long hydrophobic tails and double bonds was prepared and a VES fracturing fluid with a low concentration of GLO was developed. …”
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    Gemini Surfactant with Unsaturated Long Tails for Viscoelastic Surfactant (VES) Fracturing Fluid Used in Tight Reservoirs
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    “…Moreover, this transfection process was not cytotoxic because the viability of COS-7 cells remained at high levels, greater than 80%. …”
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    Multidisciplinary Approach to the Transfection of Plasmid DNA by a Nonviral Nanocarrier Based on a Gemini–Bolaamphiphilic Hybrid Lipid
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    “…In this study the toxic effect of the 12-5-12 gemini surfactant was investigated on Chlorella cells and close attention was paid to a potential mechanism of its action. …”
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    Anti-algal activity of the 12-5-12 gemini surfactant results from its impact on the photosynthetic apparatus
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    Density Functional Theory Studies on New Possible Biobased Gemini Corrosion Inhibitors Derived from Fatty Hydrazide Derivatives
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    “…STUDIES INCLUDED [CLINCIALTRIALS.GOV, NUMBER]: GEMINI 1 [NCT00783718]; GEMINI 2 [NCT00783692]; GEMINI 3 [NCT01224171].…”
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    Incidence of Arthritis/Arthralgia in Inflammatory Bowel Disease with Long-term Vedolizumab Treatment: Post Hoc Analyses of the GEMINI Trials
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