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22“…Starting from simple cellular interaction rules we show that it is possible to achieve perfect self-nonself discrimination in a consistent framework provided positive and negative selection operate during repertoire education, and costimulation and anergy are also considered during T cell activation. …”
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23“…This plasma membrane localized signalosome activates PI3K leading to generation of PIP3 critical for membrane localization and activation of plecktrin homology domain-containing effectors. Conversely, in anergic B cells, chronic antigen stimulation drives biased monophosphorylation of CD79 ITAMs leading to recruitment of Lyn, but not Syk, which docks only to bi-phosphorylated ITAMS. …”
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24por Dormegny-Jeanjean, Ludovic Christophe, de Billy, Clément, Mainberger, Olivier, Weibel, Sébastien, Schorr, Benoit, Obrecht, Alexandre, Landré, Lionel, Berna, Fabrice, Causin, Jean-Baptiste, Blanc, Frederic, Danila, Vlad, Tomsa, Mihaela, Pfleger, Geraldine, Meyer, Camille, Humbert, Ilia, Javelot, Hervé, Meyer, Guillaume, Bertschy, Gilles, Foucher, Jack Rene“…INTRODUCTION: Among treatment-resistant depression (TRD), we identified anergic-anhedonic clinical presentations (TRAD) as putatively responsive to pro-dopaminergic strategies. …”
Publicado 2023
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25Publicado 1992“…Hence, memory T cells, in general, are anergized by SEB. These results suggest that SEB- induced activation and anergy reflect the combined responses of naive and memory T cells. …”
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26Publicado 1994“…These data indicate that T cell clonal anergy results in profound inhibition of proliferative responses, since the autocrine growth factor, IL-2, is not produced, and the APC-derived cytokine, IL-12, is not an effective stimulus for anergic T cell proliferation.…”
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27“…Clonal anergy of autoreactive B cells is a key mechanism regulating tolerance. …”
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28por Arruga, Francesca, Rubin, Marta, Papazoglou, Despoina, Iannello, Andrea, Ioannou, Nikolaos, Moia, Riccardo, Rossi, Davide, Gaidano, Gianluca, Coscia, Marta, Laurenti, Luca, D’Arena, Giovanni, Allan, John N., Furman, Richard R., Vaisitti, Tiziana, Ramsay, Alan G., Deaglio, Silvia“…Together, these data suggest that TIGIT contributes to CLL anergy by down-regulating BCR signaling, identifying novel and actionable molecular circuits regulating anergy and modulating CLL cell functions.…”
Publicado 2023
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29por Ono, Chisato, Tanaka, Shinya, Myouzen, Keiko, Iwasaki, Takeshi, Ueda, Mahoko, Oda, Yoshinao, Yamamoto, Kazuhiko, Kochi, Yuta, Baba, Yoshihiro“…B cell anergy plays a critical role in maintaining self-tolerance by inhibiting autoreactive B cell activation to prevent autoimmune diseases. …”
Publicado 2023
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30“…IL-10 knockout mice showed a similar pattern of antiviral CD8 T cell responses: early antiviral T cells were dramatically increased and viral levels were decreased; however, CD8 T cells in IL-10 knockout mice were also eventually anergized and these mice became persistently infected. …”
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31Publicado 1991“…Instead, a state of clonal anergy is induced in both the CD4+V beta 11+ and CD8+V beta 11+ T cell subsets. …”
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32Publicado 1992“…The results suggest, however, that the total CD4 population has been driven to anergy by some potent polyclonal stimulus directly associated with viral infection.…”
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33Publicado 1994“…The loss of the CD2R is temporally associated with the inability of anergized cells to respond to LFA-3. These results suggest that in addition to blockade of B7 family members, inhibition of CD2 and, potentially, other costimulatory pathways that might reverse anergy will be necessary to maintain prolonged alloantigen-specific tolerance.…”
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34“…This state resulted from a combination of both clonal anergy and cytokine-mediated immunosuppression. The anergy persisted for at least 3 wk and could be distinguished from the suppression by a decrease in IL-2 production per cell, a block in the activation of early response kinases, and a failure to be reversed with anti–transforming growth factor (TGF)-β. …”
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36por Kalekar, Lokesh A., Schmiel, Shirdi E., Nandiwada, Sarada L., Lam, Wing Y., Barsness, Laura O., Zhang, Na, Stritesky, Gretta L., Malhotra, Deepali, Pauken, Kristen E., Linehan, Jonathan L., O’Sullivan, M. Gerard, Fife, Brian T., Hogquist, Kristin A., Jenkins, Marc K., Mueller, Daniel L.“…The role that anergy, an acquired state of T cell functional unresponsiveness, plays in natural peripheral tolerance remains unclear. …”
Publicado 2016
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37por Ledo, Camila, Gonzalez, Cintia D., Poncini, Carolina V., Mollerach, Marta, Gómez, Marisa I.“…MDSC played a major role in the generation of anergic CD4(+) T cells and their accumulation in the spleen during S. aureus sepsis correlated with IL-6 induction. …”
Publicado 2018
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38“…A similar dampening of anergy occurred after depletion of perinatal T reg cells. …”
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39“…For NK cells, it is unclear if exhaustion, anergy, and senescence entail separate and distinct entities of dysfunction, though all are typically characterized by decreased effector function or proliferation. …”
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