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Mostrando 61 - 80 Resultados de 47,000 Para Buscar 'Hanergy~', tiempo de consulta: 7.92s Limitar resultados
  1. 61
    “…Since NK92 cells have relatively lower levels of cytotoxicity when compared to primary NK cells, and have the ability to increase secretion of regulatory cytokines IL-10 and IL-6, we used these cells as a model of NK cell anergy to identify and to study the upstream regulators of anergy. …”
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    Regulation of split anergy in natural killer cells by inhibition of cathepsins C and H and cystatin F
  2. 62
    “…Self-tolerance by clonal anergy of B cells is marked by an increase in IgD and decrease in IgM antigen receptor surface expression, yet the function of IgD on anergic cells is obscure. …”
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    IgD attenuates the IgM-induced anergy response in transitional and mature B cells
  3. 63
    “…However, the role of Sema3A in CD4(+) T cell anergy during sepsis remains to be elucidated. In the present study, the cecal ligation and perforation model and lipopolysaccharide (LPS) were used to simulate sepsis and the role of Sema3A in sepsis-induced CD4(+) T cell anergy was investigated in vivo and in vitro. …”
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    Semaphorin 3A contributes to sepsis-induced immunosuppression by impairing CD4(+) T cell anergy
  4. 64
    Publicado 2003
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    HiEnergy Technologies announces scientific advisory board
  5. 65
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    Repertoire analysis of anergic B cells from patients with systemic lupus erythematosus
  6. 66
    “…Most patients are characterised by an indolent disease course and an anergic phenotype of their leukaemia cells, which refers to a state of unresponsiveness to B cell receptor stimulation. …”
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    NFAT2 is a critical regulator of the anergic phenotype in chronic lymphocytic leukaemia
  7. 67
    “…Recent findings indicate a global distortion of B cell functional capability, in which the entire repertoire of naïve and memory B cells in SLE exhibits an anergic or postactivated (APA) functional phenotype. …”
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    Therapeutic implications of the anergic/postactivated status of B cells in systemic lupus erythematosus
  8. 68
    “…The aim of the current study was to assess the major animal health problems and their impact on beef cattle production in Doba district of West Harerghe Zone, Ethiopia. The study area was purposively selected, and a simple random sampling method was used to selected households' fatteners from each kebele and interviewed using structured questionnaires. …”
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    Assessment of Major Animal Health Problems and Their Impact on Beef Cattle Production in Doba District of West Harerghe Zone, Ethiopia
  9. 69
    Publicado 1990
    “…These findings indicate that the requirement for the induction of antigen-specific anergy is different between CD4+ and CD8+ T cells in post-thymic tolerance, and the existence of coanergic signals for the induction of T cell anergy is suggested.…”
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    Selective anergy of V beta 8+,CD4+ T cells in Staphylococcus enterotoxin B-primed mice
  10. 70
    “…Therefore, systemic T cell exhaustion or anergy was not responsible for the growth of the antigenic cancer cells. …”
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    Antigenic Cancer Cells Grow Progressively in Immune Hosts without Evidence for T Cell Exhaustion or Systemic Anergy
  11. 71
    “…SEA stimulation also induces a state of hypo-responsiveness (anergy). We characterized the components of the T cell receptor (TCR) during induction of anergy by SEA. …”
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    Uncoupling of T Cell Receptor Zeta Chain Function during the Induction of Anergy by the Superantigen, Staphylococcal Enterotoxin A
  12. 72
    “…To address whether excess CD40L also perturbs clonal anergy, another self-tolerance mechanism of B cells whereby B cells are functionally inactivated and excluded from follicles in the peripheral lymphoid tissue, we crossed CD40L-transgenic mice with the anti-DNA H chain transgenic mouse line 3H9, in which Ig λ1+ anti-DNA B cells are anergized. …”
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    Excess CD40L does not rescue anti-DNA B cells from clonal anergy
  13. 73
    “…This subtype of CD4(+)CD25(−)CD69(+)LAG3(+) T cells has been recognized as induced regulatory phenotype promoting anergy in activated T cells. Indeed, we observed that CBD treatment results in upregulation of EGR2 (a key T cell anergy inducer) mRNA transcription in stimulated T(MOG) cells. …”
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    Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells
  14. 74
    “…In this study, we describe a case of rapidly fatal PML with JCV T-cell anergy in a renal transplant patient treated with CTLA4-Ig (belatacept, a CD28-B7 costimulation blocker and T-cell anergy inducer). …”
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    Refractory T-Cell Anergy and Rapidly Fatal Progressive Multifocal Leukoencephalopathy After Prolonged CTLA4 Therapy
  15. 75
    “…Our results show that FOXO1 is continuously required for all the phenotypic characteristics of memory-effector T cells such that with acute inactivation of the gene encoding FOXO1, T cells revert to a short-lived effector phenotype, exhibit reduced viability, and manifest characteristics of anergy.…”
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    Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8(+) T cells
  16. 76
    “…Taken together, these results suggest that the three probiotic strains tested lead to alterations in immune responses, i.e., induction of a tolerogenic anergy and anti-inflammatory responses. This anergy could be linked to cecal microbiota modifications, although no impact on fecal short-chain fatty acid (SCFA) concentrations was detected. …”
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    Three Candidate Probiotic Strains Impact Gut Microbiota and Induce Anergy in Mice with Cow's Milk Allergy
  17. 77
    “…Self-reactive B cells not controlled by receptor editing or clonal deletion may become anergic. We report that fully mature human B cells negative for surface IgM and retaining only IgD are autoreactive and functionally attenuated (referred to as naive IgD(+)IgM(−) B cells [B(ND)]). …”
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    Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors
  18. 78
    “…G-DC display low stimulatory capacity and induce anergy in naïve T cells, but do not confer suppressive function. …”
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    Granulocyte-colony stimulating factor drives the in vitro differentiation of human dendritic cells that induce anergy in naïve T cells
  19. 79
    “…However, the transcriptional regulation of T cell anergy has been poorly understood. Using the key anergy target gene diacylglycerol kinase (DGK) α as a focal point, we identified early growth response gene 2 (Egr2) as a central transcription factor that regulates the anergic state. …”
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    Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo
  20. 80
    “…CONCLUSIONS: Inability to eliminate haemozoin is likely involved in the persistent lymphocyte activation and in the anergic responses of Saimiri splenocytes to P. falciparum pRBC, with important negative impact in immune responses and implications for the design of malaria vaccine.…”
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    Splenic architecture disruption and parasite-induced splenocyte activation and anergy in Plasmodium falciparum-infected Saimiri sciureus monkeys
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