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61“…Since NK92 cells have relatively lower levels of cytotoxicity when compared to primary NK cells, and have the ability to increase secretion of regulatory cytokines IL-10 and IL-6, we used these cells as a model of NK cell anergy to identify and to study the upstream regulators of anergy. …”
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62por Sabouri, Zahra, Perotti, Samuel, Spierings, Emily, Humburg, Peter, Yabas, Mehmet, Bergmann, Hannes, Horikawa, Keisuke, Roots, Carla, Lambe, Samantha, Young, Clara, Andrews, T. Dan, Field, Matthew, Enders, Anselm, Reed, Joanne H., Goodnow, Christopher C.“…Self-tolerance by clonal anergy of B cells is marked by an increase in IgD and decrease in IgM antigen receptor surface expression, yet the function of IgD on anergic cells is obscure. …”
Publicado 2016
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63por Gao, Yulei, Wang, Chunxue, Wang, Ziyi, Li, Wenjie, Liu, Yancun, Shou, Songtao, Chai, Yanfen“…However, the role of Sema3A in CD4(+) T cell anergy during sepsis remains to be elucidated. In the present study, the cecal ligation and perforation model and lipopolysaccharide (LPS) were used to simulate sepsis and the role of Sema3A in sepsis-induced CD4(+) T cell anergy was investigated in vivo and in vitro. …”
Publicado 2021
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66por Märklin, Melanie, Heitmann, Jonas S., Fuchs, Alexander R., Truckenmüller, Felicia M., Gutknecht, Michael, Bugl, Stefanie, Saur, Sebastian J., Lazarus, Juliane, Kohlhofer, Ursula, Quintanilla-Martinez, Leticia, Rammensee, Hans-Georg, Salih, Helmut R., Kopp, Hans-Georg, Haap, Michael, Kirschniak, Andreas, Kanz, Lothar, Rao, Anjana, Wirths, Stefan, Müller, Martin R.“…Most patients are characterised by an indolent disease course and an anergic phenotype of their leukaemia cells, which refers to a state of unresponsiveness to B cell receptor stimulation. …”
Publicado 2017
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67“…Recent findings indicate a global distortion of B cell functional capability, in which the entire repertoire of naïve and memory B cells in SLE exhibits an anergic or postactivated (APA) functional phenotype. …”
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68por Geletu, Umer Seid, Musa, Ahmedin Abdureman, Waqe, Sisay Lemma, Usmael, Munera Ahmednur, Mummed, Yesihak Yusuf, Bari, Fufa Dawo, Ibrahim, Abdulmuen Mohammed“…The aim of the current study was to assess the major animal health problems and their impact on beef cattle production in Doba district of West Harerghe Zone, Ethiopia. The study area was purposively selected, and a simple random sampling method was used to selected households' fatteners from each kebele and interviewed using structured questionnaires. …”
Publicado 2021
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69Publicado 1990“…These findings indicate that the requirement for the induction of antigen-specific anergy is different between CD4+ and CD8+ T cells in post-thymic tolerance, and the existence of coanergic signals for the induction of T cell anergy is suggested.…”
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70por Wick, Maresa, Dubey, Purnima, Koeppen, Hartmut, Siegel, Christopher T., Fields, Patrick E., Chen, Lieping, Bluestone, Jeffrey A., Schreiber, Hans“…Therefore, systemic T cell exhaustion or anergy was not responsible for the growth of the antigenic cancer cells. …”
Publicado 1997
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71“…SEA stimulation also induces a state of hypo-responsiveness (anergy). We characterized the components of the T cell receptor (TCR) during induction of anergy by SEA. …”
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72“…To address whether excess CD40L also perturbs clonal anergy, another self-tolerance mechanism of B cells whereby B cells are functionally inactivated and excluded from follicles in the peripheral lymphoid tissue, we crossed CD40L-transgenic mice with the anti-DNA H chain transgenic mouse line 3H9, in which Ig λ1+ anti-DNA B cells are anergized. …”
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73por Kozela, Ewa, Juknat, Ana, Kaushansky, Nathali, Ben-Nun, Avraham, Coppola, Giovanni, Vogel, Zvi“…This subtype of CD4(+)CD25(−)CD69(+)LAG3(+) T cells has been recognized as induced regulatory phenotype promoting anergy in activated T cells. Indeed, we observed that CBD treatment results in upregulation of EGR2 (a key T cell anergy inducer) mRNA transcription in stimulated T(MOG) cells. …”
Publicado 2015
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74por Dekeyser, Manon, de Goër de Herve, Marie-Ghislaine, Hendel-Chavez, Houria, Labeyrie, Céline, Adams, David, Nasser, Ghaïdaa Adebs, Gasnault, Jacques, Durrbach, Antoine, Taoufik, Yassine“…In this study, we describe a case of rapidly fatal PML with JCV T-cell anergy in a renal transplant patient treated with CTLA4-Ig (belatacept, a CD28-B7 costimulation blocker and T-cell anergy inducer). …”
Publicado 2017
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75por Delpoux, Arnaud, Michelini, Rodrigo Hess, Verma, Shilpi, Lai, Chen-Yen, Omilusik, Kyla D., Utzschneider, Daniel T., Redwood, Alec J., Goldrath, Ananda W., Benedict, Chris A., Hedrick, Stephen M.“…Our results show that FOXO1 is continuously required for all the phenotypic characteristics of memory-effector T cells such that with acute inactivation of the gene encoding FOXO1, T cells revert to a short-lived effector phenotype, exhibit reduced viability, and manifest characteristics of anergy.…”
Publicado 2018
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76por Esber, Nathalie, Mauras, Aurélie, Delannoy, Johanne, Labellie, Chantal, Mayeur, Camille, Caillaud, Marie-Aurore, Kashima, Toma, Souchaud, Landry, Nicolis, Ioannis, Kapel, Nathalie, Waligora-Dupriet, Anne-Judith“…Taken together, these results suggest that the three probiotic strains tested lead to alterations in immune responses, i.e., induction of a tolerogenic anergy and anti-inflammatory responses. This anergy could be linked to cecal microbiota modifications, although no impact on fecal short-chain fatty acid (SCFA) concentrations was detected. …”
Publicado 2020
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77por Duty, J. Andrew, Szodoray, Peter, Zheng, Nai-Ying, Koelsch, Kristi A., Zhang, Qingzhao, Swiatkowski, Mike, Mathias, Melissa, Garman, Lori, Helms, Christina, Nakken, Britt, Smith, Kenneth, Farris, A. Darise, Wilson, Patrick C.“…Self-reactive B cells not controlled by receptor editing or clonal deletion may become anergic. We report that fully mature human B cells negative for surface IgM and retaining only IgD are autoreactive and functionally attenuated (referred to as naive IgD(+)IgM(−) B cells [B(ND)]). …”
Publicado 2009
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78“…G-DC display low stimulatory capacity and induce anergy in naïve T cells, but do not confer suppressive function. …”
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79por Zheng, Yan, Zha, Yuanyuan, Driessens, Gregory, Locke, Frederick, Gajewski, Thomas F.“…However, the transcriptional regulation of T cell anergy has been poorly understood. Using the key anergy target gene diacylglycerol kinase (DGK) α as a focal point, we identified early growth response gene 2 (Egr2) as a central transcription factor that regulates the anergic state. …”
Publicado 2012
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80por Alves, Francisco A, Pelajo-Machado, Marcelo, Totino, Paulo RR, Souza, Mariana T, Gonçalves, Evonnildo C, Schneider, Maria Paula C, Muniz, José APC, Krieger, Marco A, Andrade, Marcia CR, Daniel-Ribeiro, Cláudio Tadeu, Carvalho, Leonardo JM“…CONCLUSIONS: Inability to eliminate haemozoin is likely involved in the persistent lymphocyte activation and in the anergic responses of Saimiri splenocytes to P. falciparum pRBC, with important negative impact in immune responses and implications for the design of malaria vaccine.…”
Publicado 2015
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