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Mostrando 101 - 120 Resultados de 47,000 Para Buscar 'Hanergy~', tiempo de consulta: 3.50s Limitar resultados
  1. 101
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    Regulation of T cell and monocyte activation by human anergic/suppressive CD4 CD25 T cells
  2. 102
    “…Here, we describe the outcome of patients with high-risk/advanced stage hematologic malignancies, who received T-cell depleted (TCD) haploidentical-HSCT (haplo-HSCT) combined with donor T lymphocytes pretreated with IL-10 (ALT-TEN trial). IL-10-anergized donor T cells (IL-10-DLI) contained T regulatory type 1 (Tr1) cells specific for the host alloantigens, limiting donor-vs.…”
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    Immunological Outcome in Haploidentical-HSC Transplanted Patients Treated with IL-10-Anergized Donor T Cells
  3. 103
    “…Surprisingly, this approach failed to eradicate well-established tumors, in part due to the induction of anergy in cytotoxic CD8(+) T cells. Further work revealed that anergic CD8(+) T cells could be rescued by combining a dendritic cell-targeted vaccine with combination immunotherapy. …”
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    Combinatorial immunotherapeutic approaches to restore the function of anergic tumor-reactive cytotoxic CD8(+) T cells
  4. 104
    “…Instead, these CD4(+) T cells are driven toward anergy or peripherally-induced Treg (pTreg) differentiation, from the early stage of tumor development. …”
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    Induction of anergic or regulatory tumor-specific CD4(+) T cells in the tumor-draining lymph node
  5. 105
    “…Divergent hypotheses exist to explain how signaling by the B cell receptor (BCR) is initiated after antigen binding and how it is qualitatively altered in anergic B cells to selectively uncouple from nuclear factor κB and c-Jun N-terminal kinase pathways while continuing to activate extracellular signal–regulated kinase and calcium–nuclear factor of activated T cell pathways. …”
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    Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-κB in B cell clonal anergy
  6. 106
    Publicado 1992
    “…In competition experiments, we demonstrated that the induction of anergy in HA1.7 by SEB is unaffected by the presence of SEC2. …”
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    Major histocompatibility complex independent clonal T cell anergy by direct interaction of Staphylococcus aureus enterotoxin B with the T cell antigen receptor
  7. 107
    Publicado 1990
    “…This anergic state disappeared when the T cells left the thymus and reached LN.…”
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    Strong T cell tolerance in parent----F1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy
  8. 108
    Publicado 1995
    “…The signal these molecules mediate is distinguished from other costimulatory signals by the finding that T cell recognition of antigen results in a prolonged state of T cell unresponsiveness or anergy, unless these costimulatory molecules are engaged. …”
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    A pathway of costimulation that prevents anergy in CD28- T cells: B7- independent costimulation of CD1-restricted T cells
  9. 109
    “…We propose that Bacillus anthracis–derived LT causes a novel form of functional anergy in NKT cells and therefore has potential for contributing to immune evasion by the pathogen.…”
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    Bacillus anthracis Lethal Toxin Disrupts TCR Signaling in CD1d-Restricted NKT Cells Leading to Functional Anergy
  10. 110
    “…We posit FTY720 can induce an anergy-polarized phenotype switch on DCs in vitro, especially upon endotoxic activation. …”
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    Topographical and Biological Evidence Revealed FTY720-Mediated Anergy-Polarization of Mouse Bone Marrow-Derived Dendritic Cells In Vitro
  11. 111
    “…T cell receptor (TCR) signals can elicit full activation with acquisition of effector functions or a state of anergy. Here, we ask whether microRNAs affect the interpretation of TCR signaling. …”
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    microRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4 T cells
  12. 112
    por Janik, David K, Lee, William T
    Publicado 2015
    “…The data are most consistent with in vivo T cell anergy as opposed to indirect suppression as elimination of Fyn kinase restored helper function. …”
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    Staphylococcal Enterotoxin B (SEB) Induces Memory CD4 T Cell Anergy in vivo and Impairs Recall Immunity to Unrelated Antigens
  13. 113
    “…CD8(+) T cell anergy is a critical mechanism of peripheral tolerance, poorly investigated in response to immunotherapy. …”
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    TGFβ-dependent expression of PD-1 and PD-L1 controls CD8(+) T cell anergy in transplant tolerance
  14. 114
    “…B cell Expansion with NF-κB and T cell Anergy (BENTA) disease is a novel B cell lymphoproliferative disorder caused by germline, gain-of-function mutations in the lymphocyte scaffolding protein CARD11, which drives constitutive NF-κB signaling. …”
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    Intrinsic Plasma Cell Differentiation Defects in B Cell Expansion with NF-κB and T Cell Anergy Patient B Cells
  15. 115
    “…However, despite this increased IL-2 secretion, J.CaM2 cells expressing the LAT(G131D) mutant are more sensitive to inhibition of IL-2 production by pre-treatment with anti-CD3, which points to a possible role of this residue in the generation of anergy. Our results suggest that the increased kinetics of LAT Tyr132 phosphorylation could contribute to the establishment of T cell anergy, and thus constitutes an earliest known intracellular event responsible for the induction of peripheral tolerance.…”
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    Increased Protein Stability and Interleukin-2 Production of a LAT(G131D) Variant With Possible Implications for T Cell Anergy
  16. 116
    “…The physiological role of T cell anergy induction as a key mechanism supporting self-tolerance remains undefined, and natural antigens that induce anergy are largely unknown. …”
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    Self and microbiota-derived epitopes induce CD4(+) T cell anergy and conversion into CD4(+)Foxp3(+) regulatory cells
  17. 117
    “…Notably, these anergic DC subtypes showed a significant increase in septic patients. …”
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    Comprehensive single-cell analysis reveals novel anergic antigen-presenting cell subtypes in human sepsis
  18. 118
    Publicado 1994
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    Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells
  19. 119
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    Circulating anergic B cells in the periphery of active systemic lupus erythematosus patients: functional and phenotypic characterization
  20. 120
    “…DISCUSSION: We conclude that an important function of NK cells is to drive proper APC maturation via CD40L during responses to early-stage tumors, reducing development of anergic T cells. The reduced development of anergic T cells resulting in improved tumor control and T cell responses when NK cells were present.…”
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    NK cells reduce anergic T cell development in early-stage tumors by promoting myeloid cell maturation
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