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  1. 85541
    “…RESULTS: Patients with and without DM had similar plaque volume, but larger necrotic core and greater particulate debris release in patients with than without DM (20.3±2.7 vs. 12.7±2.6% and 143.9±19.3 vs. 75.1±10.4 mg, P<0.05). …”
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    Coronary aspirate TNFα reflects saphenous vein bypass graft restenosis risk in diabetic patients
  2. 85542
    “…Live microglia were de-ramified, and, in addition, process activity was severely blunted proximal to the necrotic core after IS and 24 h of reperfusion. CD11b expression, but not iNOS expression, was increased in regions of hyper- and de-ramified microglia during the course of ischemic stroke and 24 h of reperfusion. …”
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    A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion
  3. 85543
    “…To investigate if transforming growth factor beta 1 (TGF-β(1)), interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) are involved in the production of excessive immunoglobulin A (IgA), the induction of acute phase proteins and in the development of a systemic necrotizing vasculitis, characteristic of SRMA, these three signalling proteins were evaluated. …”
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    Interleukin-6, vascular endothelial growth factor and transforming growth factor beta 1 in canine steroid responsive meningitis-arteritis
  4. 85544
    “…Pronounced glucose uptake and high NADH were observed in certain localized areas within the tumor necrotic regions, indicative of the existence of viable cells which was also supported by the H&E staining. …”
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    Characterizing the metabolic heterogeneity in human breast cancer xenografts by 3D high resolution fluorescence imaging
  5. 85545
    “…Episodes of sepsis, grade of intraventricular hemorrhage, presence of a patent ductus arteriosus, number of days on the ventilator, and stage of necrotizing enterocolitis were assessed as well as days of hyperglycemia, defined as number of days with whole blood glucose > 150 mg/dl. …”
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    Hyperglycemia as a risk factor for the development of retinopathy of prematurity
  6. 85546
    “…Of particular concern is C. sakazakii, as this species is strongly associated with severe and often fatal cases of necrotizing enterocolitis and meningitis in neonates and infants. …”
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    Sialic acid utilization by Cronobacter sakazakii
  7. 85547
    “…Gr-1(+) cells could be found on the edges of necrotic lung lesions in NOS2-/-, RAG-/-, and C3HeB/FeJ, but were absent in wild-type mice. …”
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    Gr1(int)CD11b(+) Myeloid-Derived Suppressor Cells in Mycobacterium tuberculosis Infection
  8. 85548
    “…The use of an exclusive human milk-based diet is associated with decreased incidence of necrotizing enterocolitis (NEC), but concerns exist about infants achieving adequate growth. …”
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    Human milk feeding supports adequate growth in infants ≤ 1250 grams birth weight
  9. 85549
    “…Infected plants showed typical, severe necrotic lesions in storage roots at harvest 12–14 weeks after graft inoculation. …”
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    Efficient transmission of Cassava brown streak disease viral pathogens by chip bud grafting
  10. 85550
    “…Susceptibility/resistance of the investigated tumor cell lines to programmed necrosis seems to primarily depend on expression of the pro-necrotic kinase RIPK3 rather than the related kinase RIPK1 or cell surface expression of TRAIL receptors. …”
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    TRAIL-induced programmed necrosis as a novel approach to eliminate tumor cells
  11. 85551
    “…Pathological examination revealed that 1/3 of p75KD/LLC+rmTNF tumors were 100% necrotic, the remaining revealed 40-60% necrosis. No toxicity was detected in bone marrow, spleen and peripheral blood. …”
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    Therapeutic Non-Toxic Doses of TNF Induce Significant Regression in TNFR2-p75 Knockdown Lewis Lung Carcinoma Tumor Implants
  12. 85552
    “…INTRODUCTION: Necrotic tissue infection can worsen the prognosis of severe acute pancreatitis (SAP), and probiotics have been shown to be beneficial in reducing the infection rate in animal experiments and primary clinical trials. …”
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    Use of probiotics in the treatment of severe acute pancreatitis: a systematic review and meta-analysis of randomized controlled trials
  13. 85553
    “…Diagnoses were acute cervical lymphadenitis in 43 patients (57%), suppurative cervical lymphadenitis in 13 (17%), retropharyngeal or poststyloid parapharyngeal abscess in 18 (24%) and cervical necrotizing fasciitis in 1 (1%). In total, 72 patients (96%) presented fever and 34 (45%) had torticollis. …”
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    Acute cervical lymphadenitis and infections of the retropharyngeal and parapharyngeal spaces in children
  14. 85554
    “…Cactophilic Drosophila species have received much attention because larval development occurs in the necrotic tissues of cacti, and both larvae and adults feed on these tissues. …”
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    Identification of differentially expressed genes in female Drosophila antonietae and Drosophila meridionalis in response to host cactus odor
  15. 85555
    “…These results suggest that COMP-Ang1 preserved the necrotic femoral head through the potentiation of BMP-2 signaling pathways and angiogenesis. …”
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    COMP-Angiopoietin1 Potentiates the Effects of Bone Morphogenic Protein-2 on Ischemic Necrosis of the Femoral Head in Rats
  16. 85556
    “…BACKGROUND: Intestinal microbiota are implicated in risk of necrotizing enterocolitis (NEC) and sepsis, major diseases of preterm infants in neonatal intensive care units (NICUs). …”
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    Intestinal microbiota of preterm infants differ over time and between hospitals
  17. 85557
    “…The first effect presumably occurs via cytochrome C release from the inner mitochondrial membrane. A pro-necrotic effect – similar to the one of Ca(2+) – can be strong opening of mitochondrial pores leading to breakdown of the membrane potential, ATP depletion, sustained Ca(2+) increase and premature activation of digestive enzymes. …”
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    Anti-inflammatory effects of reactive oxygen species – a multi-valued logical model validated by formal concept analysis
  18. 85558
    “…Instead, SIM+MET treatment led to Ripk1- and Ripk3-dependent necrosis by 48–96 h, determined by propidium iodide-Annexin V flow cytometry, increase in Ripk1 and Ripk3 protein expression, necrosome formation, HMGB-1 extracellular release, and necrotic induction and viability rescue with necrostatin-1 and Ripk3-targeting siRNA. …”
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    Combination simvastatin and metformin induces G1-phase cell cycle arrest and Ripk1- and Ripk3-dependent necrosis in C4-2B osseous metastatic castration-resistant prostate cancer cells
  19. 85559
    “…At the first nephrology consultation, obesity, pallor, bilateral flank masses with ballottement, and two ulcers with a dark necrotic center on the distal left leg were noted. …”
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    Calciphylaxis in end-stage renal disease prior to dialytic treatment: a case report and literature review
  20. 85560
    “…The objective of this study was to assist the preclinical development of NHS-IL12, an immunocytokine consisting of an antibody, which targets necrotic tumor regions, linked to IL-12. Specifically this study sought to evaluate the safety, serum pharmacokinetics, anti-tumor activity, and immune modulation of NHS-IL12 in dogs with naturally occurring cancers. …”
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    Defining the Pharmacodynamic Profile and Therapeutic Index of NHS-IL12 Immunocytokine in Dogs with Malignant Melanoma
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