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  1. 1361
    por Ogawa, Tsuneo, de Bold, Adolfo J
    Publicado 2014
    “…The concept of the heart as an endocrine organ arises from the observation that the atrial cardiomyocytes in the mammalian heart display a phenotype that is partly that of endocrine cells. …”
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  2. 1362
  3. 1363
  4. 1364
  5. 1365
  6. 1366
    “…Analysis of the explanted hearts from heart transplant recipients provides valuable clinical samples, which can be used to study the anatomy and pathology of the heart. …”
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  7. 1367
  8. 1368
  9. 1369
  10. 1370
    “…Overall, there was a strong narrow-sense heritability of 0.62 (SE 0.124) for relative attraction and 0.67 (0.354) for flight activity based on the average of ten measurements. …”
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  11. 1371
    “…We propose a definition of this parameter that is framed within the classical quantitative genetics theory and show that the genomic heritability and the trait heritability parameters are equal only when all causal variants are typed. …”
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  12. 1372
  13. 1373
    “…In this paper, we develop the latter approach, make it computationally efficient and compare it to the frequentist approach. We show theoretically that, for a sufficiently large sample size and intermediate values of heritability, the two approaches provide similar results. …”
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  14. 1374
  15. 1375
    “…It is found in excitable cells, such as cardiomyocytes, where it plays an important role in the buffering and transport of chemical energy to ensure that supply meets the dynamic demands of the heart. Multiple components of the CK system, including intracellular creatine levels, are reduced in heart failure, while ischaemia and hypoxia represent acute crises of energy provision. …”
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  16. 1376
  17. 1377
  18. 1378
  19. 1379
  20. 1380
    “…Heart failure is a disease with high incidence and prevalence in the population. …”
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