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  1. 7801
    Libro
    Ensayos sobre historia de la medicina /
  2. 7802
    Libro
    Paisajes de occidente
  3. 7803
    por Malishev, Mijail
    Publicado 1997
    Libro
    Antología de la filosofía política : la doctrina iusnaturalista de los siglos XVII-XVIII
  4. 7804
    Publicado 1958
    Libro
    Hombres ilustres mexicanos : biografias de los personajes notables desde antes de la conquista hasta nuestros dias /
  5. 7805
    Publicado 2015
    Libro
    Estudios comparados en educación : aplicación en el análisis sobre la formación de ciudadanía, problemáticas socio-culturales e históricas /
  6. 7806
    “…Following this approach, a Gumpertz model was adapted with official data from the state of Hidalgo, Mexico, in order to estimate the people infected during this COVID-19 pandemic. …”
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    Online Artículo Texto
    Prediction and Potential Spatially Explicit Spread of COVID-19 in Mexico’s Megacity North Periphery
  7. 7807
    “…METHODOLOGY/PRINCIPAL FINDINGS: In an effort to further improve the pharmacological profile of pimelic diphenylamide HDACIs as potential therapeutics for FRDA, we synthesized additional compounds with this basic structure and screened them for HDAC3 specificity. …”
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    Texto
    Two New Pimelic Diphenylamide HDAC Inhibitors Induce Sustained Frataxin Upregulation in Cells from Friedreich's Ataxia Patients and in a Mouse Model
  8. 7808
    “…Similarly, Wee1 shRNA knock-down significantly sensitized cells to HDACIs. While AZD1775 induced Chk1 activation, reflected by markedly increased Chk1 S296/S317/S345 phosphorylation leading to inhibitory T14 phosphorylation of cdc2/Cdk1, these compensatory responses were sharply abrogated by HDACIs. …”
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    Online Artículo Texto
    A regimen combining the Wee1 inhibitor AZD1775 with HDAC inhibitors targets human acute myeloid leukemia cells harboring various genetic mutations
  9. 7809
    “…These findings offer a mechanistic rationale for the application of HDACIs in gallbladder carcinoma treatment.…”
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    Online Artículo Texto
    Histone Deacetylase Inhibitors Inhibit the Proliferation of Gallbladder Carcinoma Cells by Suppressing AKT/mTOR Signaling
  10. 7810
    “…Despite some success with certain hematological malignancies and in contrast with the strong pro-apoptotic effects measured in vitro, the overall response rate of acute lymphoblastic leukemia (ALL) to histone deacetylase inhibitors (HDACis) is low. With the aim to improve the understanding of how HDACis work in vivo, we investigated the therapeutic efficacy of the clinically approved HDACi Givinostat in a collection of nine pediatric human T-ALL engrafted systemically in NOD/SCID mice. …”
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    Online Artículo Texto
    An immediate transcriptional signature associated with response to the histone deacetylase inhibitor Givinostat in T acute lymphoblastic leukemia xenografts
  11. 7811
    “…To assess whether HDACis can upregulate CD20 also in vivo in CLL, the HDACi valproate was given to three del13q/NOTCH1wt CLL patients and CD20 levels were analysed (the PREVAIL study). …”
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    Online Artículo Texto
    The HDAC inhibitor valproate induces a bivalent status of the CD20 promoter in CLL patients suggesting distinct epigenetic regulation of CD20 expression in CLL in vivo
  12. 7812
    “…Histone deacetylase inhibitors (HDACIs) cause oncogene-transformed mammalian cell death. …”
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    Online Artículo Texto
    Histone deacetylase inhibitor trichostatin A and autophagy inhibitor chloroquine synergistically exert anti-tumor activity in H-ras transformed breast epithelial cells
  13. 7813
    “…Urine and stool samples were collected from the 1,138 residents of the Al Hidaib and Khour Ajwal villages of White Nile State, Sudan in 2014. …”
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    Epidemiological Survey on Schistosomiasis and Intestinal Helminthiasis among Village Residents of the Rural River Basin Area in White Nile State, Sudan
  14. 7814
    por Lawlor, Liam, Yang, Xuebin B.
    Publicado 2019
    “…Histone deacetylase inhibitors (HDACis) can inhibit these enzymes, resulting in the increased acetylation of histones, thereby affecting gene expression. …”
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    Online Artículo Texto
    Harnessing the HDAC–histone deacetylase enzymes, inhibitors and how these can be utilised in tissue engineering
  15. 7815
    “…This review elaborated influences on gene expression and tumorigenesis by acetylation and the antitumor mechanism of HDACis. Besdes, we outlined the preclinical and clinical advancement of HDACis in GBM as monotherapies and combination therapies.…”
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    Online Artículo Texto
    The application of histone deacetylases inhibitors in glioblastoma
  16. 7816
    “…Also, we proved that HDACis could inhibit the proliferation and metastasis of NSCLC cells in vitro. …”
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    Online Artículo Texto
    Bioinformatics-Based Identification of HDAC Inhibitors as Potential Drugs to Target EGFR Wild-Type Non-Small-Cell Lung Cancer
  17. 7817
    “…In this review, we focused on the epigenetic modifiers histone deacetylase inhibitors (HDACis) and on their ability to regulate specific genes and proteins involved in the fluoropyrimidine metabolism and resistance mechanisms. …”
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    Epigenetic Approaches to Overcome Fluoropyrimidines Resistance in Solid Tumors
  18. 7818
    “…We explored the effects of the histone deacetylase (HDAC) inhibitors (HDACis) trichostatin A (TSA) and vorinostat (SAHA) on CPP formation. …”
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    Histone Deacetylase Inhibitors Downregulate Calcium Pyrophosphate Crystal Formation in Human Articular Chondrocytes
  19. 7819
    “…Further, HDACs regulate T-cell development and HDAC inhibitors (HDACis) have been approved for clinical use in some T-cell malignancies. …”
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    Online Artículo Texto
    Quantitative Acetylomics Uncover Acetylation-Mediated Pathway Changes Following Histone Deacetylase Inhibition in Anaplastic Large Cell Lymphoma
  20. 7820
    por Acosta Medellín, Ramiro
    Publicado 1996
    Tesis Libro
    Propuesta de un programa de mantenimiento predictivo para el sistema de bombeo de agua en la Central Termoeléctrica Poza Rica/
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