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  1. 8701
    “…RNA-seq studies demonstrated oncogenic/survival signaling pathways activated by HDACi were attenuated by the EC359 + HDACi therapy. …”
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    LIFR inhibition enhances the therapeutic efficacy of HDAC inhibitors in triple negative breast cancer
  2. 8702
    “…The transcriptional response to HDACi is complex, as is the response to HDAC isoform knockdown (KD). …”
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    Differential effects of class I isoform histone deacetylase depletion and enzymatic inhibition by belinostat or valproic acid in HeLa cells
  3. 8703
    por Ellis, Leigh, Pili, Roberto
    Publicado 2010
    “…One such event is the dysregulation of histone deacetylases (HDACs) in both hematological and solid tumors, and has consequently resulted in the development of HDAC inhibitors (HDACI) to overcome this. HDACI exhibit pleiotropic biological effects including inhibition of angiogenesis and the induction of autophagy and apoptosis. …”
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    Histone Deacetylase Inhibitors: Advancing Therapeutic Strategies in Hematological and Solid Malignancies
  4. 8704
    “…HDACi contain potent therapeutic potential against RMS. …”
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    A review of the therapeutic potential of histone deacetylase inhibitors in rhabdomyosarcoma
  5. 8705
    “…Histone deacetylase inhibitors (HDACi) have shown promising antitumor effects on numerous cancer cells including malignant pleural mesothelioma (MPM) and lung adenocarcinoma (ADCA) cells. …”
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    New histone deacetylase inhibitors improve cisplatin antitumor properties against thoracic cancer cells
  6. 8706
    “…Controversially, histone deacetylase inhibitors (HDACi) are in clinical trial for the treatment of inherited retinal degeneration. …”
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    A Brain-Derived Neurotrophic Factor Mimetic Is Sufficient to Restore Cone Photoreceptor Visual Function in an Inherited Blindness Model
  7. 8707
    “…Pharmacological treatment of Duchenne muscular dystrophy (DMD) with histone deacetylase inhibitors (HDACi) is currently being tested in clinical trials; however, pre‐clinical studies indicated that the beneficial effects of HDACi are restricted to early stages of disease. …”
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    Determinants of epigenetic resistance to HDAC inhibitors in dystrophic fibro‐adipogenic progenitors
  8. 8708
    “…Histone deacetylase inhibitors (HDACi) have been approved and achieved success in hematologic malignancies. …”
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    Nanotechnology-Based Histone Deacetylase Inhibitors for Cancer Therapy
  9. 8709
    “…An even more novel combination therapy with HDACi is to use them with an oncolytic virus. HDACi may lead to an amplification of tumor-specific lytic effects by facilitating increased cycles of viral replication, but there may also be direct anticancer effects of the drug by itself. …”
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    Combining HDAC inhibitors with oncolytic virotherapy for cancer therapy
  10. 8710
    “…The histone deacetylase inhibitor (HDACi) has been investigated for treating cancers and many other diseases as well as enhancing the reprogramming efficiency in cloned embryos for decades. …”
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    Novel histone deacetylase inhibitors and embryo aggregation enhance cloned embryo development and ES cell derivation in pigs
  11. 8711
    “…BACKGROUND: Numerous immune genes are epigenetically silenced in tumor cells and agents such as histone deacetylase inhibitors (HDACi), which reverse these effects, could potentially be used to develop therapeutic vaccines. …”
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    An epigenetic vaccine model active in the prevention and treatment of melanoma
  12. 8712
    “…While histone deacetylase inhibitors (HDACi) suppress NE cancer growth by inducing Notch, the molecular mechanism underlying this interplay has not yet been defined. …”
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    Antineoplastic effects of histone deacetylase inhibitors in neuroendocrine cancer cells are mediated through transcriptional regulation of Notch1 by activator protein 1
  13. 8713
    “…Here, we compile known molecular signals and pathways involved in the HDACi-triggered induction of apoptosis and autophagy. …”
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    p53 at the Crossroads between Different Types of HDAC Inhibitor-Mediated Cancer Cell Death
  14. 8714
    “…Histone deacetylase inhibitors (HDACi) are active against leukemic cells in vitro and in vivo. …”
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    HDAC3 Activity is Essential for Human Leukemic Cell Growth and the Expression of β-catenin, MYC, and WT1
  15. 8715
    “…The enhanced effect of histone deacetylase inhibitors (HDACi) to tumor lysate vaccine was observed. The expressions of MHC-I pathway molecules were detected by flow cytometry and western blot after HDACi treatment. …”
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    Histone deacetylase inhibition up-regulates MHC class I to facilitate cytotoxic T lymphocyte-mediated tumor cell killing in glioma cells
  16. 8716
    “…Several inhibitors of HDACs (HDACi) are developed and exhibit powerful antitumor abilities. …”
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    HDAC Inhibition Decreases the Expression of EGFR in Colorectal Cancer Cells
  17. 8717
    “…Although histone deacetylase inhibitors (HDACi) are a promising class of anti-cancer drugs, thus far, they have been unsuccessful in early phase clinical trials for pancreatic ductal adenocarcinoma (PDAC). …”
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    Histone deacetylase inhibitors provoke a tumor supportive phenotype in pancreatic cancer associated fibroblasts
  18. 8718
    “…Although histone deacetylase inhibitor could not enhance cell death in HDACi-R but upregulation of miR-107 decreased cell viability both in parental cells and resistance cells, decreased the expression of cofilin-1, enhanced ROS-induced cell apoptosis, and dose-dependently sensitized HDACi-R to HDACi. …”
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    Hsa-miR-107 regulates chemosensitivity and inhibits tumor growth in hepatocellular carcinoma cells
  19. 8719
    “…Promising preclinical studies supporting HDAC targeting for SS treatment were not reflected in clinical trials with HDAC inhibitor (HDACi) monotherapies. We investigated pathways implicated in SS cell response to HDACi to identify vulnerabilities exploitable in combination treatments and improve the therapeutic efficacy of HDACi-based regimens. …”
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    Upregulation of ERK-EGR1-heparanase axis by HDAC inhibitors provides targets for rational therapeutic intervention in synovial sarcoma
  20. 8720
    “…BACKGROUND: The genome-wide hyperacetylation of chromatin caused by histone deacetylase inhibitors (HDACi) is surprisingly well tolerated by most eukaryotic cells. …”
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    Cells adapt to the epigenomic disruption caused by histone deacetylase inhibitors through a coordinated, chromatin-mediated transcriptional response
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