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  1. 8721
    “…Histone deacetylase inhibitor (HDACi) could inhibit proliferation and promote apoptosis of Hepatocellular carcinoma (HCC) cells. …”
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    YY1 promotes HDAC1 expression and decreases sensitivity of hepatocellular carcinoma cells to HDAC inhibitor
  2. 8722
    “…Further, the combined use of HDACi with other chemotherapy agents, or radiotherapy, has shown promising pre-clinical results and various HDACi have progressed to different stages in clinical trials. …”
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    Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma
  3. 8723
    “…However, most patients showed no response to HDACi monotherapy for unknown reasons. Here we show that sensitivity and resistance to the hydroxamate HDACi, PXD101, can be modeled in DLBCL cell lines. …”
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    A model of sensitivity and resistance to histone deacetylase inhibitors in diffuse large B cell lymphoma: Role of cyclin-dependent kinase inhibitors
  4. 8724
    “…This review summarizes the HDACs classification, their aberrant expression in cancerous tissue, structures, sources, and the anticancer mechanisms of HDACi, as well as HDACi that are either FDA-approved or under clinical trials.…”
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    Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy
  5. 8725
    “…The clinical use of histone deacetylase inhibitors (HDACi) for the treatment of bone marrow failure and hematopoietic malignancies has increased dramatically over the last decades. …”
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    Transcriptomic and Epigenomic Profiling of Histone Deacetylase Inhibitor Treatment Reveals Distinct Gene Regulation Profiles Leading to Impaired Neutrophil Development
  6. 8726
    “…Histone deacetylase inhibitors (HDACi) were identified nearly four decades ago based on their ability to induce cellular differentiation. …”
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    Sustained Low-Dose Treatment with the Histone Deacetylase Inhibitor LBH589 Induces Terminal Differentiation of Osteosarcoma Cells
  7. 8727
    “…Histone deacetylase inhibitors (HDACi) and DNA methyltransferase inhibitors (DNMTi) are in early clinical development for multiple myeloma (MM) therapy. …”
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    In vivo treatment with epigenetic modulating agents induces transcriptional alterations associated with prognosis and immunomodulation in multiple myeloma
  8. 8728
    “…In this review, we summarize HDACi-mediated mechanisms of action, particularly with respect to the induction of cell death. …”
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    Epigenetic Targeting of Autophagy via HDAC Inhibition in Tumor Cells: Role of p53
  9. 8729
    “…To our surprise, a combination of HDACi and HMTi or HDACi and DNMTi showed a strong synergy to induce the expressions of most HDP genes. …”
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    Epigenetic Regulation of Host Defense Peptide Synthesis: Synergy Between Histone Deacetylase Inhibitors and DNA/Histone Methyltransferase Inhibitors
  10. 8730
    “…However, HDAC inhibitors (HDACi) only regulate a small subset of this population in a cell type dependent fashion. …”
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    Histone deacetylase inhibitor-based chromatin precipitation for identification of targeted genomic loci
  11. 8731
    por Hassell, Kelly N.
    Publicado 2019
    “…Histone deacetylases (HDAC) and histone deacetylase inhibitors (HDACi) have greatly impacted the war on cancer. Their role in epigenetics has significantly altered the development of anticancer drugs used to treat the most rare, persistent forms of cancer. …”
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    Histone Deacetylases and Their Inhibitors in Cancer Epigenetics
  12. 8732
    “…Histone deacetylase inhibitors (HDACi) have demonstrated promising therapeutic potential in clinical trials for hematological malignancies. …”
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    Anti-Leukemia Activity of MS-275 Histone Deacetylase Inhibitor Implicates 4-1BBL/4-1BB Immunomodulatory Functions
  13. 8733
    “…Histone deacetylase inhibitors (HDACi) are increasingly used as therapeutic agents, but the mechanisms by which they alter cell behaviour remain unclear. …”
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    Genes Are Often Sheltered from the Global Histone Hyperacetylation Induced by HDAC Inhibitors
  14. 8734
    por Peedicayil, Jacob
    Publicado 2020
    “…Most drug trials investigating the use of epigenetic drugs for treating ADs have used histone deacetylase inhibitors (HDACi). HDACi are showing favorable results in both preclinical and clinical drug trials for treating ADs. …”
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    The Potential Role of Epigenetic Drugs in the Treatment of Anxiety Disorders
  15. 8735
    Publicado 2021
    “…Therefore, the study on how HDACi enhances the efficacy of ICIs is of great significance to tumor immunotherapy. …”
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    组蛋白去乙酰化酶抑制剂联合免疫检查点抑制剂治疗肿瘤的研究进展
  16. 8736
    “…Histone deacetylases (HDAC) are key players in epigenetic regulation of gene expression and HDAC inhibitor (HDACi) treatment seems to be a promising anticancer therapy in many human tumours, including soft tissue sarcomas. …”
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    HR23b expression is a potential predictive biomarker for HDAC inhibitor treatment in mesenchymal tumours and is associated with response to vorinostat
  17. 8737
    “…AIM: To study the need of patient stratification before HDACi treatment, and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug sensitizer. …”
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    Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer
  18. 8738
    “…In order to determine the optimal specificity for HDACi correction of the mutant NPC1s, we screened 76 HDACi's of varying specificity. …”
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    Inhibition of Histone Deacetylases 1, 2, and 3 Enhances Clearance of Cholesterol Accumulation in Niemann-Pick C1 Fibroblasts
  19. 8739
    por Zhou, Lei, He, Xiran, Gao, Bo, Xiong, Sidong
    Publicado 2015
    “…CVB3-infected BALB/c mice were treated with the HDAC inhibitor (HDACI) suberoylanilide hydroxamic acid (SAHA) or trichostatin A (TSA). …”
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    Inhibition of Histone Deacetylase Activity Aggravates Coxsackievirus B3-Induced Myocarditis by Promoting Viral Replication and Myocardial Apoptosis
  20. 8740
    “…BACKGROUND: Histone deacetylase inhibitors (HDACi) are a new class of promising anti-tumour agent inhibiting cell proliferation and survival in tumour cells with very low toxicity toward normal cells. …”
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    Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells
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