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  1. 8761
    “…Histone deacetylase inhibitors (HDACi), epigenetic modifier drugs, are commonly used but effective in only ~30% of patients. …”
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    Novel cell adhesion/migration pathways are predictive markers of HDAC inhibitor resistance in cutaneous T cell lymphoma
  2. 8762
    “…Nanoparticle encapsulation could be one approach to improve the delivery of HDACi to target tissues; however, effective and generalizable loading of HDACi within nanoparticle systems remains a long-term challenge. …”
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    β-Cyclodextrin-poly (β-Amino Ester) Nanoparticles Are a Generalizable Strategy for High Loading and Sustained Release of HDAC Inhibitors
  3. 8763
    “…However, the mechanism underlying its suppression by HDACi still requires elucidation. We hypothesized that HDACi induce genes responsible for destabilizing and inactivating FOXM1. …”
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    Histone Deacetylase Inhibitor-Induced CDKN2B and CDKN2D Contribute to G2/M Cell Cycle Arrest Incurred by Oxidative Stress in Hepatocellular Carcinoma Cells via Forkhead Box M1 Suppression
  4. 8764
    “…Histone deacetylase inhibitors (HDACi) have shown promising activity against hematological malignancies in clinical trials and have led to the approval of vorinostat for the treatment of cutaneous T-cell lymphoma. …”
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    Vorinostat-induced autophagy switches from a death-promoting to a cytoprotective signal to drive acquired resistance
  5. 8765
    “…Given the role of epigenetic aberrations in the pathogenesis and progression of MM and the success of histone deacetylase inhibitors (HDACi) in other malignancies, many HDACi have been tried in MM. …”
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    Clinical use and applications of histone deacetylase inhibitors in multiple myeloma
  6. 8766
    “…Based on the evidence of a pivotal role for HDACi and DNMTi in modulating various components belonging to the immune system, recent clinical trials have shown that both HDACi and DNMTi strongly augmented response to anti-PD-1 immunotherapy in different tumour types. …”
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    Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy
  7. 8767
    “…CONCLUSION: HDACi suppress the epithelial–mesenchymal transition (EMT) and compromise the DNA integrity of cancer cells. …”
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    Histone deacetylase inhibitors dysregulate DNA repair proteins and antagonize metastasis-associated processes
  8. 8768
    “…All four HDACi showed potent activity and increased hyperacetylation of the histone-4 protein. …”
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    Antitheilerial Activity of the Anticancer Histone Deacetylase Inhibitors
  9. 8769
    “…Among them, 130 patients received HiDAC alone with total dose of 2–3 g/m(2) × 6 while 508 patients received multiple-agent combination chemotherapy (multiagent chemo group). …”
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    Does High-Dose Cytarabine Cause More Fungal Infection in Patients With Acute Myeloid Leukemia Undergoing Consolidation Therapy: A Multicenter, Prospective, Observational Study in China
  10. 8770
    por Ceccacci, Elena, Minucci, Saverio
    Publicado 2016
    “…Histone deacetylases (HDACs) are a key component of the epigenetic machinery regulating gene expression, and behave as oncogenes in several cancer types, spurring the development of HDAC inhibitors (HDACi) as anticancer drugs. This review discusses new results regarding the role of HDACs in cancer and the effect of HDACi on tumour cells, focusing on haematological malignancies, particularly acute myeloid leukaemia. …”
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    Inhibition of histone deacetylases in cancer therapy: lessons from leukaemia
  11. 8771
    “…The histone deacetylase inhibitors (HDACi) have demonstrated anticancer efficacy across a range of malignancies, most impressively in the hematological cancers. …”
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    Histone deacetylase inhibitors: potential targets responsible for their anti-cancer effect
  12. 8772
    “…Here, we explore the current evidence for the use of HDACi in combination with irradiation, focusing on the effects of HDACi on DNA damage signalling and repair in vitro. …”
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    Histone deacetylase inhibitors as radiosensitisers: effects on DNA damage signalling and repair
  13. 8773
    “…This review summarizes the roles of HDACs as novel therapeutic targets and the molecular mode of action of HDAC-inhibitors (HDACI) in PDACs. Success of HDACI in clinical settings will depend on an increased knowledge of HDAC functions as well as on a better understanding of the mode of action of HDACI. …”
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    Targeting histone deacetylases in pancreatic ductal adenocarcinoma
  14. 8774
    “…With this system, we screened an in-house small-molecule library and identified a group of histone deacetylase inhibitors (HDACi) increasing prime editing. We also found that HDACi increased the efficiency of both cytosine base editing (CBE) and adenine base editing (ABE). …”
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    HDAC inhibitors improve CRISPR-Cas9 mediated prime editing and base editing
  15. 8775
    “…We aimed to review preclinical studies evaluating the organ protection effects of histone deacetylase inhibitors (HDACi) with a view to informing the design of early phase clinical trials. …”
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    Systematic review and meta-analysis of experimental studies evaluating the organ protective effects of histone deacetylase inhibitors
  16. 8776
    “…4-Hexylresorcinol (4HR) has been used as a food additive, however, it has been recently demonstrated as a Class I histone deacetylase inhibitor (HDACi). Unlike other HDACi, 4HR can be taken through foods. …”
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    Effects of 4-Hexylresorcinol on Craniofacial Growth in Rats
  17. 8777
    “…BACKGROUND: Histone deacetylase inhibitors (HDACi) display potent therapeutic efficacy in animal models of arthritis and suppress inflammatory cytokine production in rheumatoid arthritis (RA) synovial macrophages and tissue. …”
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    Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay
  18. 8778
    “…In contrast, P. gingivalis internalization and intracellular survival in GFs remained unaffected by HDACi. Activation of mitogen-activated protein kinases and NFκB signaling was unaffected by global or HDAC3/6-selective HDACi, and new protein synthesis was not required for gene suppression by HDACi. …”
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    HDAC3 Regulates Gingival Fibroblast Inflammatory Responses in Periodontitis
  19. 8779
    “…The mechanism of action of histone deacetylase inhibitors (HDACi) is mainly attributed to the inhibition of the deacetylase catalytic activity for their histone substrates. …”
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    Scaffold dependent histone deacetylase (HDAC) inhibitor induced re-equilibration of the subcellular localization and post-translational modification state of class I HDACs
  20. 8780
    por Peedicayil, Jacob
    Publicado 2016
    “…Preclinical drug trials of DNMTi and HDACi for the treatment of MS are showing promising results. …”
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    Epigenetic Drugs for Multiple Sclerosis
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