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  1. 8781
    “…Herein, we describe the synthesis and biological evaluation of HDACi prodrugs with photo-cleavable protecting groups masking the zinc-binding group of the established HDACi DDK137 (I) and VK1 (II). …”
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    Photocaged Histone Deacetylase Inhibitors as Prodrugs in Targeted Cancer Therapy
  2. 8782
    “…Glioblastoma has shown resistance to histone deacetylase inhibitors (HDACi) as radiosensitizers in cultures with Bcl-XL over-expression. …”
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    The Bcl-2 inhibitor Obatoclax overcomes resistance to histone deacetylase inhibitors SAHA and LBH589 as radiosensitizers in patient-derived glioblastoma stem-like cells
  3. 8783
    “…Although in preclinical studies HDACi's have proven anti-myeloma activity, but in the clinic single-agent HDACi treatments have been limited due to low tolerability. …”
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    HDAC inhibitor AR-42 decreases CD44 expression and sensitizes myeloma cells to lenalidomide
  4. 8784
    “…In detail, we highlighted the role of HDACi in solid cancers and, specifically, in the CSC subpopulation and we pointed out some mechanisms by which HDACi are able to overcome drug resistance and to modulate stemness. …”
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    Implication for Cancer Stem Cells in Solid Cancer Chemo-Resistance: Promising Therapeutic Strategies Based on the Use of HDAC Inhibitors
  5. 8785
    “…Transcriptomics analysis identified selective alteration of mRNA processing and splicing modules that might underlie the potent anti-MM effects of combining HDACi and oHSV. In vivo, HDACi treatment increased intratumoral oHSV replication and boosted the capacity of oHSV to control the growth of human MM xenografts. …”
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    Histone deacetylase inhibitors enhance oncolytic herpes simplex virus therapy for malignant meningioma
  6. 8786
    por Jordaan, Gwen, Liao, Wei, Sharma, Sanjai
    Publicado 2013
    “…The downstream effects of HDACi treated leukemic cells were studied by analyzing the effect on wnt-pathway signaling. …”
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    E-cadherin gene re-expression in chronic lymphocytic leukemia cells by HDAC inhibitors
  7. 8787
    por Koeneke, Emily, Witt, Olaf, Oehme, Ina
    Publicado 2015
    “…The effect of HDACi on autophagy and, conversely, the effect of autophagy on HDACi efficacy are currently under investigation. …”
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    HDAC Family Members Intertwined in the Regulation of Autophagy: A Druggable Vulnerability in Aggressive Tumor Entities
  8. 8788
    “…Herein, we show that a class of compound, HDAC inhibitors (HDACi) induced KLF2 expression in monocytes both in vitro and in vivo. …”
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    Induction of Krüppel‐like factor 2 reduces K/BxN serum‐induced arthritis
  9. 8789
    “…HDACi slowed breast cancer cell proliferation and reduced primary tumor growth. …”
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    HDAC inhibitors induce LIFR expression and promote a dormancy phenotype in breast cancer
  10. 8790
    “…Clinical trials have demonstrated single agent HDACi to have activity in hematological malignancies, in particular T-cell lymphoma and Hodgkin lymphoma. …”
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    Overview of Histone Deacetylase Inhibitors in Haematological Malignancies
  11. 8791
    “…The protein expression profiles of untreated and HDACi-treated CD8(+) T cells were analyzed using two-dimensional gel electrophoresis. …”
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    Characterization of the effect of histone deacetylation inhibitors on CD8(+) T cells in the context of aging
  12. 8792
    “…A support vector machine (SVM)-based classifier predicted all HDACi correctly. For validation, the classifier was applied to legacy data sets of HDACi, and for each exposure situation, the SVM predictions correlated with the developmental toxicity. …”
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    A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors
  13. 8793
    “…BACKGROUND: Small molecule inhibitors of histone deacetylases (HDACi) hold promise as anticancer agents for particular malignancies. …”
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    HDAC inhibitors cause site-specific chromatin remodeling at PU.1-bound enhancers in K562 cells
  14. 8794
    “…In contrast to class I/IIb/pan histone deacetylase inhibitors (HDACi), the role of class IIa HDACi as anti-cancer chemosensitizing agents is less well understood. …”
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    Synergistic Interaction of the Class IIa HDAC Inhibitor CHDI0039 with Bortezomib in Head and Neck Cancer Cells
  15. 8795
    “…We found that 19f is superior to the clinically tested class-I HDACi Entinostat (MS-275). Thus, 19f is a new and specific HDACi with the potential to eliminate blood cancer cells of various origins.…”
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    Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity
  16. 8796
    “…Previous approaches focused on the histone deacetylase inhibitor (HDACi) Valproate as a latency-reversing agent to boost Tax expression and expose infected cells to the host’s immune response. …”
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    HDAC inhibitors Panobinostat and Romidepsin enhance tax transcription in HTLV-1-infected cell lines and freshly isolated patients’ T-cells
  17. 8797
    “…Through the use of siRNA or isoform-specific HDACi, we demonstrated that HDAC3 is the main isoform whose inhibition is involved in the modulation of TP. …”
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    Valproic acid potentiates the anticancer activity of capecitabine in vitro and in vivo in breast cancer models via induction of thymidine phosphorylase expression
  18. 8798
    “…Additionally, HDACi have been shown to enhance the cytotoxic effects of DNA-damaging agents such as radiation and cisplatin. …”
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    Class I HDAC Inhibition Leads to a Downregulation of FANCD2 and RAD51, and the Eradication of Glioblastoma Cells
  19. 8799
    “…RESULTS: We found that HDACi inhibited cell proliferation and that the pan-HDACi TSA induced G0/G1 arrest in LEC. …”
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    The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways
  20. 8800
    por Ungerstedt, Johanna S.
    Publicado 2018
    “…Thus, there is a strong rationale supporting HDACi therapy in myeloid malignancies. However, despite initial promising results in phase I trials, HDACi in monotherapy as well as in combination with other drugs, have failed to improve responses or survival. …”
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    Epigenetic Modifiers in Myeloid Malignancies: The Role of Histone Deacetylase Inhibitors
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